Fecal Microbiota Transplantation Activity of Floccularia luteovirens Polysaccharides and Their Protective Effect on Cyclophosphamide-Induced Immunosuppression and Intestinal Injury in Mice DOI Creative Commons

He Ma,

Abdul Mueed, Yi Ma

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(23), P. 3881 - 3881

Published: Nov. 30, 2024

polysaccharides (FLP1s) have potential biological activities. Our previous study showed that FLP1s positively regulated gut immunity and microbiota. However, it is still unclear whether mediate microbiota in immunosuppressed mice. This research aims to explore the relationship between FLP1-mediated microbes intestinal mice through fecal transplantation (FMT). The results demonstrated exhibited prebiotic anti-immunosuppressive effects on CTX-induced FFLP1 treatment (microbiota from sample) remarkably elevated production of sIgA secretion anti-inflammatory cytokines IL-4, TNF-α, IFN-γ intestine CTX-treated mice, inducing activation MAPK pathway. Moreover, FFLP1s mitigated oxidative stress by activating Nrf2/Keap1 signaling pathway strengthened barrier function upregulating expression level tight junction proteins (occludin, claudin-1, MUC-2, ZO-1). Furthermore, FFPL1s restored dysbiosis increasing abundance

Language: Английский

Antimicrobial and Antioxidant Activities of a Brown Wood Rotting Mushroom <i>Piptoporellus</i> <i>b</i><i>audonii</i> from Benin (Tropical Africa) DOI Open Access

Olyvia Gwladys Fadeyi,

Boris Armel Olou, Roland T. Tchuenguem

et al.

Advances in Biological Chemistry, Journal Year: 2024, Volume and Issue: 14(05), P. 145 - 170

Published: Jan. 1, 2024

Language: Английский

Citations

0
Fecal Microbiota Transplantation Activity of Floccularia luteovirens Polysaccharides and Their Protective Effect on Cyclophosphamide-Induced Immunosuppression and Intestinal Injury in Mice DOI Creative Commons

He Ma,

Abdul Mueed, Yi Ma

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(23), P. 3881 - 3881

Published: Nov. 30, 2024

polysaccharides (FLP1s) have potential biological activities. Our previous study showed that FLP1s positively regulated gut immunity and microbiota. However, it is still unclear whether mediate microbiota in immunosuppressed mice. This research aims to explore the relationship between FLP1-mediated microbes intestinal mice through fecal transplantation (FMT). The results demonstrated exhibited prebiotic anti-immunosuppressive effects on CTX-induced FFLP1 treatment (microbiota from sample) remarkably elevated production of sIgA secretion anti-inflammatory cytokines IL-4, TNF-α, IFN-γ intestine CTX-treated mice, inducing activation MAPK pathway. Moreover, FFLP1s mitigated oxidative stress by activating Nrf2/Keap1 signaling pathway strengthened barrier function upregulating expression level tight junction proteins (occludin, claudin-1, MUC-2, ZO-1). Furthermore, FFPL1s restored dysbiosis increasing abundance

Language: Английский

Citations

0