Mengding Yellow Bud Polyphenols Protect Against CCl4‐induced Hepatotoxicity in Mice Via Inhibiting Oxidative Stress and Inflammation DOI
Ranran Wang,

Fei She,

Ruokun Yi

et al.

Journal of Food Science, Journal Year: 2025, Volume and Issue: 90(5)

Published: May 1, 2025

ABSTRACT Mengding yellow bud polyphenols (MYBPs), as a plant active ingredient that may protect the liver, have not yet been elucidated for potential molecular mechanism in preventing carbon tetrachloride (CCl 4 ) induced acute liver injury (ALI) mice. The MYBPs monomers compounds were explored by high‐performance liquid chromatography (HPLC). Mice administered silymarin (100 mg/kg b.w.) or (50 and 100 2 weeks prior to CCl ‐induced ALI. function indexes, histopathological observation, biochemical mRNA protein expressions determine. effectively reduced mice weights, pathological injury, serum levels of alanine aminotransferase (ALT), aspartate (AST), triglycerides (TG), total cholesterol (TC). Similarly, decreased interleukin (IL)‐6, IL‐12, tumor necrosis factor‐α (TNF‐α), interferon (IFN)‐γ levels, tissues myeloperoxidase (MPO) malondialdehyde (MDA) elevated superoxide dismutase (SOD) glutathione (GSH) levels. cuprozinc‐superoxide (Cu/Zn‐SOD), manganese‐superoxide (Mn‐SOD), catalase (CAT), B‐cells inhibitor‐α (IκB‐α) markedly increased. Additionally, significantly nuclear factor (NF)‐κB, TNF‐α, IL‐1 beta, inducible NOS (iNOS), cyclooxygenase (COX)‐2 expressions. HPLC showed contained gallic acid (GA), (−)‐epigallocatechin (EGC), epigallocatechin gallate (EGCG), (−)‐epicatechin (ECG). Briefly, prevented ALI inhibiting oxidative stress inflammatory pathways, its preventive effect was dose‐dependent with concentration. This study provided scientific basis development into functional food well new idea clinical prevention treatment human Practical Application : can alleviate Hepatotoxicity raising antioxidant antiinflammatory status upregulating antiinflammatory‐related genes protein.

Language: Английский

Regulation of pyroptosis by natural products in ulcerative colitis: mechanisms and therapeutic potential DOI Creative Commons

Xiaobei Lu,

Yapeng Sun, Zhaoyi Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 9, 2025

Ulcerative colitis (UC), a chronic inflammatory bowel disease, is driven by dysregulated immune responses and persistent intestinal inflammation. Pyroptosis, caspase/gasdermin-mediated cell death that exacerbates mucosal damage through excessive cytokine release epithelial barrier disruption. Although pyroptosis considered to be key mechanism in the pathogenesis of UC, systematic assessment role natural products targeting pathway remains critical research gap. The purpose this review investigate regulatory effects on UC elucidate mechanisms action potential therapeutic effects. Key findings highlight polyphenols (e.g., resveratrol), flavonoids Quercetin), terpenoids as promising agents inhibit NLRP3 inflammasome activation, suppress gasdermin D cleavage, restore integrity, thereby reducing pro-inflammatory preclinical models. Current evidence shows enhanced efficacy safety when these compounds are combined with standard therapies, but clinical translation requires overcoming three barriers: limited human trial data, uncharacterized polypharmacology, suboptimal pharmacokinetics needing formulation refinement. Future should prioritize standardized animal-to-human translational models, mechanistic studies synergistic pathways, rigorous validation harness full pyroptosis-targeted therapies.

Language: Английский

Citations

0
Mengding Yellow Bud Polyphenols Protect Against CCl4‐induced Hepatotoxicity in Mice Via Inhibiting Oxidative Stress and Inflammation DOI
Ranran Wang,

Fei She,

Ruokun Yi

et al.

Journal of Food Science, Journal Year: 2025, Volume and Issue: 90(5)

Published: May 1, 2025

ABSTRACT Mengding yellow bud polyphenols (MYBPs), as a plant active ingredient that may protect the liver, have not yet been elucidated for potential molecular mechanism in preventing carbon tetrachloride (CCl 4 ) induced acute liver injury (ALI) mice. The MYBPs monomers compounds were explored by high‐performance liquid chromatography (HPLC). Mice administered silymarin (100 mg/kg b.w.) or (50 and 100 2 weeks prior to CCl ‐induced ALI. function indexes, histopathological observation, biochemical mRNA protein expressions determine. effectively reduced mice weights, pathological injury, serum levels of alanine aminotransferase (ALT), aspartate (AST), triglycerides (TG), total cholesterol (TC). Similarly, decreased interleukin (IL)‐6, IL‐12, tumor necrosis factor‐α (TNF‐α), interferon (IFN)‐γ levels, tissues myeloperoxidase (MPO) malondialdehyde (MDA) elevated superoxide dismutase (SOD) glutathione (GSH) levels. cuprozinc‐superoxide (Cu/Zn‐SOD), manganese‐superoxide (Mn‐SOD), catalase (CAT), B‐cells inhibitor‐α (IκB‐α) markedly increased. Additionally, significantly nuclear factor (NF)‐κB, TNF‐α, IL‐1 beta, inducible NOS (iNOS), cyclooxygenase (COX)‐2 expressions. HPLC showed contained gallic acid (GA), (−)‐epigallocatechin (EGC), epigallocatechin gallate (EGCG), (−)‐epicatechin (ECG). Briefly, prevented ALI inhibiting oxidative stress inflammatory pathways, its preventive effect was dose‐dependent with concentration. This study provided scientific basis development into functional food well new idea clinical prevention treatment human Practical Application : can alleviate Hepatotoxicity raising antioxidant antiinflammatory status upregulating antiinflammatory‐related genes protein.

Language: Английский

Citations

0