A review on probiotics and dietary bioactives: Insights on metabolic well-being, gut microbiota, and inflammatory responses

Food Chemistry Advances, Journal Year: 2025, Volume and Issue: 6, P. 100919 - 100919

Published: Feb. 11, 2025

Language: Английский

---

Beyond Cholesterol: Emerging Risk Factors in Atherosclerosis

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2352 - 2352

Published: March 29, 2025

Atherosclerosis remains a leading cause of cardiovascular morbidity and mortality worldwide, traditionally linked to elevated cholesterol levels, particularly low-density lipoprotein (LDL-C). However, despite aggressive lipid-lowering strategies, residual risk persists, underscoring the need explore additional contributing factors. This review examines emerging factors beyond cholesterol, including chronic inflammation, gut microbiota composition, oxidative stress, environmental exposures. Inflammation plays pivotal role in atherogenesis, with markers such as C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) serving indicators disease activity. The microbiome, metabolites like trimethylamine N-oxide (TMAO), has been implicated vascular inflammation plaque development, while beneficial short-chain fatty acids (SCFAs) demonstrate protective effects. Oxidative stress further exacerbates endothelial dysfunction instability, driven by reactive oxygen species (ROS) lipid peroxidation. Additionally, factors, air pollution, heavy metal exposure, endocrine disruptors, psychological have emerged significant contributors disease. Understanding these novel offers broader perspective on atherosclerosis pathogenesis provides new avenues for targeted prevention therapeutic interventions.

Language: Английский

---

Back to Roots: Dysbiosis, Obesity, Metabolic Syndrome, Type 2 Diabetes Mellitus, and Obstructive Sleep Apnea—Is There an Objective Connection? A Narrative Review

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 4057 - 4057

Published: Nov. 26, 2024

In recent decades, it has become clear that the gut is more than just a digestive organ; also functions as an immune organ with regulatory capabilities and acts “second brain” influences brain function due to presence roles of microbiota (GM). The GM crucial component its host significantly impacts human health. Dysbiosis, or microbial imbalance, been closely linked various diseases, including gastrointestinal, neurological, psychiatric, metabolic disorders. aim this narrative review highlight in maintaining Sleep vital biological necessity, living organisms having evolved internal sleep–wake rhythm aligns roughly 24 h light/dark cycle, known circadian rhythm. This cycle essential for tissue repair, restoration, overall optimal body functioning. irregularities have prevalent modern society, fast-paced lifestyles often disrupting normal sleep patterns. Urban factors, such fast food consumption, shift work, exposure artificial light nighttime noise, medications, social activities, can adversely affect rhythms, dysbiosis being one many factors incriminated etiology

Language: Английский

---

Targeted microbiota dysbiosis repair: An important approach to health management after spinal cord injury

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102648 - 102648

Published: Dec. 1, 2024

Language: Английский

---