Facile Formulation of a Resveratrol-Mediated Multibond Network Hydrogel with Efficient Sustainable Antibacterial, Reactive Oxygen Species Scavenging, Pro-Angiogenesis, and Immunomodulation Activities for Accelerating Infected Wound Healing DOI
Jing Feng, Zifei Wang, Xiyu Li

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

The management of chronic infected wounds remains a significant clinical challenge, largely due to the deficiency optimal wound dressings with adequate mechanical strength, appropriate adhesiveness, and efficient sustainable antibacterial, reactive oxygen species (ROS) scavenging, pro-angiogenesis, immunomodulation properties. To address such dilemma, we employed simple facile strategy utilize resveratrol (RSV) as functional component mediate hydrogel gelation in this study. structure obtained was supported by multibond network, which not only endowed resultant product superior strength moderate adhesiveness but also effectively prolonged bioavailability RSV. This successfully integrated entire system ROS Subsequent vivo evidence has verified that material capable accelerate healing wounds. underlying mechanism can be explained is propelling macrophage polarization from M1 M2 phenotype through modulating PI3K/AKT signaling pathway activate nuclear factor erythroid 2-related 2 (Nrf2) well maintaining mitochondrial membrane potential level normal state under excessive inflammatory oxidative stimulus. In summary, multifunctional dressing provides feasible way promote RSV, conducive for preparing promising candidate healing. What more important, it beneficial reveal correlative mechanisms establish advanced therapeutic platform targeting other complex infection microenvironment.

Language: Английский

Facile Formulation of a Resveratrol-Mediated Multibond Network Hydrogel with Efficient Sustainable Antibacterial, Reactive Oxygen Species Scavenging, Pro-Angiogenesis, and Immunomodulation Activities for Accelerating Infected Wound Healing DOI
Jing Feng, Zifei Wang, Xiyu Li

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

The management of chronic infected wounds remains a significant clinical challenge, largely due to the deficiency optimal wound dressings with adequate mechanical strength, appropriate adhesiveness, and efficient sustainable antibacterial, reactive oxygen species (ROS) scavenging, pro-angiogenesis, immunomodulation properties. To address such dilemma, we employed simple facile strategy utilize resveratrol (RSV) as functional component mediate hydrogel gelation in this study. structure obtained was supported by multibond network, which not only endowed resultant product superior strength moderate adhesiveness but also effectively prolonged bioavailability RSV. This successfully integrated entire system ROS Subsequent vivo evidence has verified that material capable accelerate healing wounds. underlying mechanism can be explained is propelling macrophage polarization from M1 M2 phenotype through modulating PI3K/AKT signaling pathway activate nuclear factor erythroid 2-related 2 (Nrf2) well maintaining mitochondrial membrane potential level normal state under excessive inflammatory oxidative stimulus. In summary, multifunctional dressing provides feasible way promote RSV, conducive for preparing promising candidate healing. What more important, it beneficial reveal correlative mechanisms establish advanced therapeutic platform targeting other complex infection microenvironment.

Language: Английский

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