Cynthichlorine Extracted from Ascidian Cynthia savignyi from Djibouti: Optimization of Extraction, In Vitro Anticancer Profiling, and In Silico Approach DOI Creative Commons
Fatouma Mohamed Abdoul‐Latif,

Houda Mohamed,

Ibrahim Houmed Aboubaker

et al.

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(4), P. 172 - 172

Published: April 16, 2025

This work focuses on the extraction of cynthichlorine from ascidian Cynthia savignyi, a molecule that has potential promise as an anticancer agent. The main objective was to optimize conditions and evaluate cytotoxic activity in tumor cell lines. Two methods, maceration Soxhlet extraction, were compared, with showing significantly higher yield (2.2 ± 0.2%) compared (1.0 0.2%). An optimization factors influencing performed using Box–Behnken method, temperature time have negative impact yield, optimal being below 25 °C those 12 h. Cytotoxic assessment revealed marked inhibition growth all tested lines (U87-MG, U2OS, NCI-N87, HCT116, A2780), IC50 values ranging 0.162 µg/mL U87-MG 0.576 NCI-N87. Finally, computational analysis showed exhibits high electronic stability notable affinity for some biological targets, including NM23-H2, suggesting its targeted therapy cancer treatment. These results pave way future studies therapeutic use cynthichlorine.

Language: Английский

Current technological solutions for processing black chokeberry berries to obtain juice and anthocyanin dyes DOI

A.V. Dakhnovich

Published: Feb. 10, 2025

The most widespread in Aronia aronia was obtained Russia territories with a cold and humid climate on relatively fertile soils of Siberia Urals, especially Altai even the Arctic. In Siberia, berry crops have number advantages over fruit crops. They are less demanding to adverse conditions, their berries richer vitamins, mineral salts organic acids. average yield bush is from 10 17 kg berries. Anthocyanin common natural pigment that highly soluble water gives vegetable products color red purple, beneficial human health. Anthocyanins flavonoid compounds belong category polyphenols. extremely sensitive changes temperature pH. nature, anthocyanins occur as glycosides aglycones (non-saccharide parts) known anthocyanidins. mountain ash, 25% all polyphenols anthocyanins. This article discusses currently technologies for complex processing ash effect juice anthocyanin dyes.

Language: Английский

Citations

0
Cynthichlorine Extracted from Ascidian Cynthia savignyi from Djibouti: Optimization of Extraction, In Vitro Anticancer Profiling, and In Silico Approach DOI Creative Commons
Fatouma Mohamed Abdoul‐Latif,

Houda Mohamed,

Ibrahim Houmed Aboubaker

et al.

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(4), P. 172 - 172

Published: April 16, 2025

This work focuses on the extraction of cynthichlorine from ascidian Cynthia savignyi, a molecule that has potential promise as an anticancer agent. The main objective was to optimize conditions and evaluate cytotoxic activity in tumor cell lines. Two methods, maceration Soxhlet extraction, were compared, with showing significantly higher yield (2.2 ± 0.2%) compared (1.0 0.2%). An optimization factors influencing performed using Box–Behnken method, temperature time have negative impact yield, optimal being below 25 °C those 12 h. Cytotoxic assessment revealed marked inhibition growth all tested lines (U87-MG, U2OS, NCI-N87, HCT116, A2780), IC50 values ranging 0.162 µg/mL U87-MG 0.576 NCI-N87. Finally, computational analysis showed exhibits high electronic stability notable affinity for some biological targets, including NM23-H2, suggesting its targeted therapy cancer treatment. These results pave way future studies therapeutic use cynthichlorine.

Language: Английский

Citations

0