3D Printed Bigel: A Novel Delivery System for Cannabidiol-Rich Hemp Extract

Gels, Journal Year: 2024, Volume and Issue: 10(12), P. 770 - 770

Published: Nov. 26, 2024

The therapeutic potential of Cannabis sativa L. extract has gained significant attention due to its diverse medical applications. Sublingual administration remains a common delivery method cannabinoids; however, challenges often arise the inconvenient form and taste. To address these issues, novel bigel formulation was developed, combining water oil phases enhance stability bioavailability. This incorporates cannabidiol-rich hemp extract, hyaluronic acid for moisturizing properties, taste-masking agent improve patient compliance comfort. Using standardized rich in cannabinoids well-characterized terpene profile, printability bigels evaluated through 3D printing technology. A printout with known cannabidiol (CBD) cannabidiolic (CBDA) content 11.613 mg ± 0.192 CBD 4.732 0.280 CBDA obtained. In addition, release profile determine efficiency active ingredient—dissolved ingredient levels ranged from 74.84% 0.50 80.87% 3.20 80.84 1.33 98.31 1.70 depending on formulation. Rheological studies were conducted evaluate viscosity under varying temperature conditions, ensuring their usability. Findings suggest that this 3D-printed could significantly cannabis extracts, offering more convenient effective option patients. research underscores importance innovation cannabinoid therapies paves way further advancements personalized medicine.

Language: Английский

Enhancing Cannabinoid Bioavailability in Pain Management: The Role of Cyclodextrins

Molecules, Journal Year: 2024, Volume and Issue: 29(22), P. 5340 - 5340

Published: Nov. 13, 2024

Chronic pain (CP), including related to cancer, affects approximately 2 billion people worldwide, significantly diminishing quality of life and imposing socio-economic burdens. Current treatments often provide limited relief may cause adverse effects, demanding more effective alternatives. Natural compounds from

Language: Английский

Polyelectrolytes and Polyelectrolyte Complexes as Future Antibacterial Agents

Bacteria, Journal Year: 2024, Volume and Issue: 3(4), P. 452 - 475

Published: Dec. 3, 2024

Antibiotic-resistance (ABR) poses a critical public health challenge within the broader antimicrobial resistance crisis. This review evaluates potential of polyelectrolytes (PEs) and polyelectrolyte complexes (PECs) for controlled antibiotic delivery as strategy to combat ABR biofilm-related infections. PECs, particularly those incorporating chitosan other polycations, enhance antibacterial efficacy by disrupting bacterial cell walls obstructing their nutrient flow. They are also effective in penetrating biofilms providing sustained drug release. Despite these advantages, there is need further vivo research clinical trials validate findings. provides comprehensive overview PECs’ advance therapies outlines future directions explore applications.

Language: Английский