Release kinetics of growth factors loaded into β-TCP ceramics in an in vitro model DOI Creative Commons

Marco Waldmann,

Marc Bohner,

Anna Baghnavi

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Sept. 27, 2024

Introduction β-TCP ceramics are bone replacement materials that have recently been tested as a drug delivery system can potentially be applied to endogenous substances like growth factors found in blood platelets facilitate positive attributes. Methods In this work, we used flow chamber loading load dowels with suspensions of platelet-rich plasma (PRP), platelet-poor (PPP), or buffy coat (BC) character. PRP and BC platelet counts were adjusted the same level by dilution. Concentrations TGF-β1, PDGF-AB, IGF-1 from dowel-surrounding culture medium subsequently determined using ELISA over 5 days. The influence alginate was additionally modify release. Results TGF-β1 PDGF-AB increased conclusively showed release compared PPP. coating reduced but did not reduce instead even samples. concentrations highest PPP, suggesting circulating levels rather than driving factor. Alginate samples tended lower concentrations, difference shown significant. Discussion different successfully demonstrated for patterns correspond activation after Ca 2+ -triggered activation. pattern partially modified coating.

Language: Английский

Optimization of Metal-Based Nanoparticle Composite Formulations and Their Application in Wound Dressings DOI Creative Commons
Menglei Wang,

Yawen Luo,

Qianwen Yang

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2813 - 2846

Published: March 1, 2025

Abstract: Metal-based nanoparticles (MNPs) have great potential for applications in wound healing and tissue engineering, due to their unique structures, high bioactivities, excellent designability characteristics, an increasing number of studies been devoted modifying these species generate novel composites with desirable optical, electrical, magnetic properties. However, few systematic detailed reviews performed relating the modification approaches available MNPs resulting composites. In this review, a comprehensive summary is regarding optimized formulations application dressings, techniques used prepare composite dressings are discussed. addition, safety profiles nanocomposite limitations reported systems evaluated. More importantly, solution strategies proposed address limitations. Overall, review provides new ideas design facilitate field skin repair, also looks into future direction biomedical field. Keywords: metal-based nanoparticles, nanocomposite, dressing, multi-functional,

Language: Английский

Citations

0
Preparation and Assessment of Novel Chitosan/Bioactive Glass Composite Foams for Exudate Management in Wound Dressing Applications DOI Creative Commons
Talita Martins, Breno Rocha Barrioni,

R.M.M. Turchetti-Maia

et al.

Materials Research, Journal Year: 2025, Volume and Issue: 28

Published: Jan. 1, 2025

Although biocomposite foams have been used as wound dressings, achieving accelerated healing with reduced complications requires precise control of exudate absorption and evaporation. This study evaluated the fluid handling capacity, water vapor transmission, cytotoxicity novel chitosan/bioactive glass composite foams. Prepared following a simple process, these up to 60% porosity interconnected pore networks. Cytotoxicity assays confirmed their non-toxicity L-929 fibroblast cells. The demonstrated liquid capacity 160%, improved performance at higher levels bioactive glass. Fluid tests showed effective moisture transfer, making dressings suitable for treatment wounds such burns pressure ulcers. transmission test ability promote high removal rates, suggesting that composites are promising dressing applications.

Language: Английский

Citations

0
Topical Probiotic Hydrogels for Burn Wound Healing DOI Creative Commons

Tavinda Arshad,

Varsha Mundrathi,

V Perez

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(9), P. 545 - 545

Published: Aug. 23, 2024

Hydrogels have increasingly been used to enhance the effective healing of various wounds, including burn wounds. Similarly, application probiotics has recently explored in wound and skin repairs. While consumed provide therapeutic effects that aid with improving gut health, topical applications found accelerate both vitro vivo. For wounds complex mechanisms, such as which depend on factors depth burn, size afflicted area, cause injury, or without conventional agents topically delivered via hydrogel technology are proven be recovery damaged skin. This article aims investigate microorganisms present human microbiome observe by hydrogels healing.

Language: Английский

Citations

3
Insights into the Preparation of and Evaluation of the Bactericidal Effects of Phage-Based Hydrogels DOI Open Access
Mengyuan Gao, Yuhan Wang,

Hanyue Zhuang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9472 - 9472

Published: Aug. 30, 2024

The rise of antibiotic-resistant strains demands new alternatives in antibacterial treatment. Bacteriophages, with their precise host specificity and ability to target eliminate bacteria safely, present a valuable option. Meanwhile, hydrogels, known for excellent biodegradability biocompatibility, serve as ideal carriers bacteriophages. combination bacteriophages hydrogels ensures heightened phage activity, concentration, controlled release, strong properties, making it promising avenue This article provides comprehensive review different crosslinking methods focusing on application treating infections caused by various drug-resistant highlighting effective properties release capabilities.

Language: Английский

Citations

0
Release kinetics of growth factors loaded into β-TCP ceramics in an in vitro model DOI Creative Commons

Marco Waldmann,

Marc Bohner,

Anna Baghnavi

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Sept. 27, 2024

Introduction β-TCP ceramics are bone replacement materials that have recently been tested as a drug delivery system can potentially be applied to endogenous substances like growth factors found in blood platelets facilitate positive attributes. Methods In this work, we used flow chamber loading load dowels with suspensions of platelet-rich plasma (PRP), platelet-poor (PPP), or buffy coat (BC) character. PRP and BC platelet counts were adjusted the same level by dilution. Concentrations TGF-β1, PDGF-AB, IGF-1 from dowel-surrounding culture medium subsequently determined using ELISA over 5 days. The influence alginate was additionally modify release. Results TGF-β1 PDGF-AB increased conclusively showed release compared PPP. coating reduced but did not reduce instead even samples. concentrations highest PPP, suggesting circulating levels rather than driving factor. Alginate samples tended lower concentrations, difference shown significant. Discussion different successfully demonstrated for patterns correspond activation after Ca 2+ -triggered activation. pattern partially modified coating.

Language: Английский

Citations

0