Reverse Gradient Distributions of Drug and Polymer Molecules within Electrospun Core–Shell Nanofibers for Sustained Release

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9524 - 9524

Published: Sept. 1, 2024

Core–shell nanostructures are powerful platforms for the development of novel nanoscale drug delivery systems with sustained release profiles. Coaxial electrospinning is facile and convenient creating medicated core–shell elaborate designs which sustained-release behaviors molecules can be intentionally adjusted. With resveratrol (RES) as a model poorly water-soluble cellulose acetate (CA) PVP polymeric carriers, brand-new electrospun nanostructure was fabricated in this study. The guest RES host CA were designed to have reverse gradient distribution within nanostructures. Scanning electron microscope transmission evaluations verified that these nanofibers had linear morphologies, without beads or spindles, an obvious double-chamber structure. X-ray diffraction patterns Fourier transform infrared spectroscopic results indicated involved components highly compatible presented amorphous molecular state. In vitro dissolution tests new structures able prevent initial burst release, extend continuous-release time period, reduce negative tailing-off effect, thus ensuring better profile than traditional blended drug-loaded nanofibers. mechanism underlying influence structure RES/CA on proposed. Based proof-of-concept demonstration, series advanced functional nanomaterials similarly developed based distributions multi-chamber

Language: Английский

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An intelligent thymol/alizarin-loaded polycaprolactone/gelatin/zein nanofibrous film with pH-responsive and antibacterial properties for shrimp freshness monitoring and preservation

Food Chemistry, Journal Year: 2025, Volume and Issue: 471, P. 142812 - 142812

Published: Jan. 7, 2025

Language: Английский

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From Lab to Shelf: Gelatin-Based pH Sensors Revolutionizing Food Packaging

Gels, Journal Year: 2025, Volume and Issue: 11(5), P. 327 - 327

Published: April 27, 2025

The development of multifunctional smart food packaging has garnered considerable attention in research. Gelatin exhibits outstanding characteristics, featuring remarkable gel strength, molecular binding affinity, excellent colloidal dispersibility, low solution viscosity, sustained dispersion stability, and significant water retention properties. Gelatin-based film is ideally suited for the developing simple, portable, rapid pH sensors, owing to its satisfactory biocompatibility, biodegradability, biosafety, affordability, facilitation easy handling usage. This paper aims explore challenges opportunities relating gelatin-based sensors. It begins by outlining sources, classifications, functional properties gelatin, followed an analysis current research landscape future trends related intelligent indicators active carriers. Subsequently, potential directions sensors are proposed. Using a literature analysis, it can be concluded that novel represents packaging. hoped provide some basic information application

Language: Английский

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Effects of gamma radiation as terminal sterilization on mechanical properties and organic composition of bone and skin allograft

Journal of materials research/Pratt's guide to venture capital sources, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Language: Английский

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Donkey Gelatin and Keratin Nanofibers Loaded with Antioxidant Agents for Wound Healing Dressings

Gels, Journal Year: 2024, Volume and Issue: 10(6), P. 391 - 391

Published: June 8, 2024

Acute and chronic wounds present a significant healthcare challenge, requiring innovative solutions for effective treatment. The exploitation of natural by-products with advanced cell regeneration potential plant-based materials, which possess bioactive properties, is an topic in wound management. This study investigates the donkey gelatin keratin blending extracts such as sumac, curcumin, oak acorn to fabricate antioxidant antimicrobial nanofibers accelerated healing processes. fabricated good vitro biocompatibility, except sumac-based nanofibers, where viability significantly dropped 56.25% (

Language: Английский

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Magnetically Induced Anisotropic Microstructures on Polyethylene Glycol Hydrogel Facilitate BMSC Alignment and Osteogenic Differentiation

Gels, Journal Year: 2024, Volume and Issue: 10(12), P. 814 - 814

Published: Dec. 11, 2024

Many tissues exhibit structural anisotropy, which imparts orientation-specific properties and functions. However, recapitulating the cellular patterns found in anisotropic presents a remarkable challenge, particularly when using soft wet hydrogels. Herein, we develop self-assembled magnetic Fe3O4 micropatterns on polyethylene glycol hydrogels utilizing dipole–dipole interactions. Under influence of static field, nanoparticles align into highly ordered structures with height 400–600 nm width 8–10 μm. Furthermore, our layer-by-layer assembly technique enables creation oriented varying densities heights, can be further manipulated to form three-dimensional by adjusting angle field. These applied various substrates, including treated glass slides, standard silicon wafers, polydimethylsiloxane. The patterned scaffolds, modified gold coating, effectively enhance adhesion, orientation, osteogenic differentiation bone marrow-derived stem cells, is crucial for effective tissue repair. Overall, this study an efficient strategy constructing micropattern hydrogels, providing bioactive platform that significantly enhances

Language: Английский

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