Evaluating the Wound Healing Potential of Characterized Bergenia ciliata–Loaded Salvia hispanica Hydrogel in Diabetic Mice

Microscopy Research and Technique, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

ABSTRACT The current study assessed the wound healing potential of Bergenia ciliata (BC) extract, BC‐loaded Salvia hispanica hydrogel (CH‐BC) and nanoparticles (NPs)–loaded (CH‐BC AgNPs/NPs‐loaded hydrogel) using in vitro vivo studies. prepared its components were analyzed UV–visible spectrophotometry (UV–vis), scanning electron microscopy (SEM), dynamic light scattering (DLS) analysis/particle size analyzer (PSA), zeta potential, fourier transform infrared spectrometry (FT‐IR), x‐ray diffraction (XRD). Peaks peak shifts at 450–460, 250–260, 270–280 nm UV–vis FT‐IR (500–4000 cm −1 ) confirmed extract loading various functional group presence. DLS nanometric BC AgNP while indicated slightly negative charge hydrogel. SEM average topography –mediated (BC AgNPs) AgNPs loaded AgNPs), XRD peaks 2ϴ (10–70) topographical crystalline porous nature materials. showed higher radical scavenging (74.19% ± 1.84%) iron chelation activity (93.70 2.20) 50 25 μL/mL, respectively, CH‐BC produced lowest (48.97% 3.0%) 75 μL/mL (54.35 3.24). Moreover, Chia (CH) synergistically enhanced (1.30%) DPPH scavenging. contraction percentage augmented as potent candidate for (14th day). These findings further supported by a significant ( p < 0.001) restoration MMP2 (184.6 11.7 pg/mL), TIMPs (184.8 15.7 GPx (153.4 11.5 IL‐6 (10 1 pg/mL) levels compared to those diabetic control. normal reepithelization, angiogenesis, maturation wounds treatment groups after histological analysis strengthened supposed rationale that CH, along with AgNPs, can act improve therapeutic results. Hence, appeared sustainable, biocompatible, nontoxic agent paved way futuristic biomedical investigations.

Language: Английский

Facile Hydrothermal Assisted Basic Catalyzed Sol Gel Synthesis for Mesoporous Silica Nanoparticle from Alkali Silicate Solutions Using Dual Structural Templates

Gels, Journal Year: 2024, Volume and Issue: 10(12), P. 839 - 839

Published: Dec. 19, 2024

This work presents a novel hydrothermally aided sol-gel method for preparation of mesoporous silica nanoparticles (MSNs) with narrow particle size distribution and varied pore sizes. The was carried out in alkaline media presence polyethylene glycol (PEG) cetyltrimethylammonium chloride (CTAC) as dual templates permitted the synthesis spherical high surface area (1011.42 m2/g). MSN materials were characterized by FTIR, Thermogravimetric (TG), Nitrogen adsorption desorption Field emission scanning electron microscopic analysis (FESEM). feasibility solid phase adsorbent has been demonstrated using cationic dyes; Rhodamine B (RB) methylene blue (MB) models. Due to large variable width, behaviors toward dyes showed outstanding removal efficiency rapid sorption rate. isotherms RB MB well-fitted Langmuir Freundlich models, while kinetic behaviours adhered closely pseudo-second-order pattern. maximum capacities determined be 256 mg/g 110.3 RB. findings suggest that MSNs hold significant potential solid-phase nanosorbents extraction purification dye pollutants, particularly treatment effluents containing dyes.

Language: Английский

Recent progress in topical and transdermal approaches for melanoma treatment

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Language: Английский