Post-Stroke Recovery: A Review of Hydrogel-Based Phytochemical Delivery Systems DOI Creative Commons

Irina Musa,

Alexandra Daniela Rotaru-Zavaleanu,

Veronica Sfredel

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 260 - 260

Published: April 1, 2025

Stroke remains a leading cause of disability worldwide, underscoring the urgent need for novel and innovative therapeutic strategies to enhance neuroprotection, support regeneration, improve functional recovery. Previous research has shown that phytochemicals such as curcumin, tannic acid, gallic ginsenosides, resveratrol, isorhamnetin display extensive neuroprotective properties, including antioxidant, anti-inflammatory, anti-apoptotic effects. These natural compounds could also promote neurogenesis, angiogenesis, preservation blood–brain barrier. Despite their promising bioactivities, clinical application is often limited by poor solubility, bioavailability, suboptimal pharmacokinetics. Hydrogels offer solution encapsulating controlling gradual release these directly at site injury. Recent advancements in hydrogel formulations, constructed from biopolymers functionalized using nanotechnological approaches, significantly stability, targeted delivery phytochemicals. Controlled profiles pH-sensitive environment-responsive hydrogels ensure compounds’ effects are optimally timed with individual critical stages post-stroke repair. Moreover, scaffolds tailored material properties biocompatibility can create favorable microenvironment, reducing secondary inflammation, enhancing tissue potentially improving cognitive outcomes following stroke. This review explores potential integrating within hydrogel-based systems specifically designed The design synthesis biocompatible, biodegradable especially applications discussed. Lastly, we emphasize additional robust translatable preclinical studies.

Language: Английский

Hydrogels for Peripheral Nerve Repair: Emerging Materials and Therapeutic Applications DOI Creative Commons

Oana Taisescu,

Venera Cristina Dinescu, Alexandra Daniela Rotaru-Zavaleanu

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 126 - 126

Published: Feb. 9, 2025

Peripheral nerve injuries pose a significant clinical challenge due to the complex biological processes involved in repair and their limited regenerative capacity. Despite advances surgical techniques, conventional treatments, such as autografts, are faced with limitations like donor site morbidity inconsistent functional outcomes. As such, there is growing interest new, novel, innovative strategies enhance regeneration. Tissue engineering/regenerative medicine its use of biomaterials an emerging example strategy. Within realm tissue engineering, functionalized hydrogels have gained considerable attention ability mimic extracellular matrix, support cell growth differentiation, even deliver bioactive molecules that can promote repair. These be engineered incorporate factors, peptides, stem cells, creating conducive microenvironment for cellular axonal Recent advancements materials well biology led development sophisticated hydrogel systems, not only provide structural support, but also actively modulate inflammation, recruitment, stimulate neurogenesis. This review explores potential peripheral repair, highlighting composition, biofunctionalization, mechanisms action. A comprehensive analysis preclinical studies provides insights into efficacy these promoting growth, neuronal survival, regeneration, and, ultimately, recovery. Thus, this aims illuminate promise transformative tool field bridging gap between complexity feasibility.

Language: Английский

Citations

1
Alcohol Consumption and Cardiovascular Disease: A Narrative Review of Evolving Perspectives and Long-Term Implications DOI Creative Commons

Ovidiu Ştefan Georgescu,

Liviu Martin,

Georgică Târtea

et al.

Life, Journal Year: 2024, Volume and Issue: 14(9), P. 1134 - 1134

Published: Sept. 9, 2024

Cardiovascular illnesses remain the primary cause of death, accounting for at least 17.9 million fatalities per year and posing a significant public health problem because its extensive predominance effect on healthcare systems. The etiology cardiovascular disease is complex involves several environmental lifestyle factors. Alcohol use highly important determinant dual-edged health. Multiple studies indicate that moderate alcohol consumption may have certain advantages, such as slight enhancements in lipid profiles. Conversely, excessive intake associated with serious negative consequences, including cardiomyopathy, hypertension, arrhythmias, even mortality. aim this study to provide comprehensive analysis effects their understanding within medical field over time. It uses an interpretative narrative review methodology analyzes focus genetic risk factors, gender differences, shifts paradigms recent years. This article highlights need obtaining thorough support guidelines clinical practice, it underscores significance into broader context management identifies subjects further study.

Language: Английский

Citations

4
Hydrogel-Based Innovations in Carpal Tunnel Syndrome: Bridging Pathophysiological Complexities and Translational Therapeutic Gaps DOI Creative Commons
Venera Cristina Dinescu,

Liviu Martin,

Marius Bică

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(1), P. 52 - 52

Published: Jan. 9, 2025

Carpal Tunnel Syndrome (CTS) is a prevalent neuropathic disorder caused by chronic compression of the median nerve, leading to sensory and motor impairments. Conventional treatments, such as corticosteroid injections, wrist splinting, surgical decompression, often fail provide adequate outcomes for or recurrent cases, emphasizing need innovative therapies. Hydrogels, highly biocompatible three-dimensional biomaterials with customizable properties, hold significant potential CTS management. Their ability mimic extracellular matrix facilitates localized drug delivery, anti-adhesion barrier formation, tissue regeneration. Advances in hydrogel engineering have introduced stimuli-responsive systems tailored biomechanical environment carpal tunnel, enabling sustained therapeutic release improved integration. Despite these promising developments, applications remain underexplored. Key challenges include absence CTS-specific preclinical models rigorous clinical validation. Addressing gaps could unlock full hydrogel-based interventions, which offer minimally invasive, solutions that improve long-term reduce recurrence rates. This review highlights hydrogels transformative approach therapy, advocating continued research address translational barriers. These innovations redefine treatment landscape, significantly enhancing patient care quality life.

Language: Английский

Citations

0
A review: Carrier-based hydrogels containing bioactive molecules and stem cells for ischemic stroke therapy DOI

Wenzhe Yin,

Yankai Jiang,

Guangrui Ma

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 49, P. 39 - 62

Published: March 5, 2025

Language: Английский

Citations

0
Post-Stroke Recovery: A Review of Hydrogel-Based Phytochemical Delivery Systems DOI Creative Commons

Irina Musa,

Alexandra Daniela Rotaru-Zavaleanu,

Veronica Sfredel

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 260 - 260

Published: April 1, 2025

Stroke remains a leading cause of disability worldwide, underscoring the urgent need for novel and innovative therapeutic strategies to enhance neuroprotection, support regeneration, improve functional recovery. Previous research has shown that phytochemicals such as curcumin, tannic acid, gallic ginsenosides, resveratrol, isorhamnetin display extensive neuroprotective properties, including antioxidant, anti-inflammatory, anti-apoptotic effects. These natural compounds could also promote neurogenesis, angiogenesis, preservation blood–brain barrier. Despite their promising bioactivities, clinical application is often limited by poor solubility, bioavailability, suboptimal pharmacokinetics. Hydrogels offer solution encapsulating controlling gradual release these directly at site injury. Recent advancements in hydrogel formulations, constructed from biopolymers functionalized using nanotechnological approaches, significantly stability, targeted delivery phytochemicals. Controlled profiles pH-sensitive environment-responsive hydrogels ensure compounds’ effects are optimally timed with individual critical stages post-stroke repair. Moreover, scaffolds tailored material properties biocompatibility can create favorable microenvironment, reducing secondary inflammation, enhancing tissue potentially improving cognitive outcomes following stroke. This review explores potential integrating within hydrogel-based systems specifically designed The design synthesis biocompatible, biodegradable especially applications discussed. Lastly, we emphasize additional robust translatable preclinical studies.

Language: Английский

Citations

0