Characteristics of Hydrogels as a Coating for Microneedle Transdermal Delivery Systems with Agomelatine

Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 322 - 322

Published: Jan. 15, 2025

Agomelatine (AGM) is an effective antidepressant with low oral bioavailability due to intensive hepatic metabolism. Transdermal administration of agomelatine may increase its and reduce the doses necessary for therapeutic effects. However, transdermal delivery requires crossing stratum corneum barrier. For this purpose, use microneedles efficiency administration. The aim study was prepare agomelatine-loaded hydrogel suitable coating drug AGM. optimized formulations were subjected spectroscopic rheological characterization mechanical tests, as well tested release through artificial membrane permeation human skin ex vivo. Both hydrogels found have parameters using dip-coating method, including stability substance at process temperature, shear-thinning behavior, appropriate textural such adhesion or hardness. Additionally, two potential application alone because gels showed properties application. In case, ethanol gel characterized by higher permeability better spreadability. information obtained in will allow preparation coated agomelatine.

Language: Английский

β-Cyclodextrin: A key player in boosting the biocompatible anti-inflammatory potential of a novel thiazole derivative

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 127436 - 127436

Published: March 1, 2025

Language: Английский