Self‐Coacervation of Oligo(ethylene glycol) and Oligo(2‐ethyl‐2‐oxazoline)‐Based Double Hydrophilic Brush Block Copolymers in Aqueous Solution

Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Abstract Coacervates are a highly relevant class of structures formed via liquid–liquid phase separation and new coacervate‐forming polymers sought after. Here, the formation simple coacervate droplets from double hydrophilic block copolymer (DHBC) with combination poly(oligo ethylene glycol methacrylate) (POEGMA) 2‐ethyl‐2‐oxazoline (POEtOx) without use external triggers or charges is shown. At high concentration 25 wt.%, DHBC forms sizes in low micrometre range. The have relatively stability over long period time only minor coalescence observed after 4 weeks. concentrations, no coacervation observed. Furthermore, copolymers monomers also do not show clearly indicating that architecture required to form desired structures. addition guest biomacromolecules at concentrations shows specific partitioning behaviour preference for polymer aqueous phase. enrichment observed, line common water‐in‐water (w/w) emulsions. These findings constitute direction systems interest biotechnology, synthetic cell environment mimics drug delivery.

Language: Английский

Decellularized Green and Brown Macroalgae as Cellulose Matrices for Tissue Engineering

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(12), P. 390 - 390

Published: Dec. 23, 2024

Scaffolds resembling the extracellular matrix (ECM) provide structural support for cells in engineering of tissue constructs. Various material sources and fabrication techniques have been employed scaffold production. Cellulose-based matrices are interest due to their abundant supply, hydrophilicity, mechanical strength, biological inertness. Terrestrial marine plants offer diverse morphologies that can replicate ECM various tissues be isolated through decellularization protocols. In this study, three macroalgae species—namely Durvillaea poha, Ulva lactuca, Ecklonia radiata—were selected morphological variation. Low-intensity, chemical treatments were developed each species maintain native cellulose structures within while facilitating clearance DNA pigment. generated from seaweed non-toxic human dermal fibroblasts but only fibrous inner layer those derived E. radiata supported cell attachment maturation over seven days culture. These findings demonstrate potential radiata-derived scaffolds skin highlight influence on efficiency, properties, utility.

Language: Английский