Enhanced Topical Delivery of Methotrexate via Transferosome-Loaded Microneedle Array Patch: Formulation, Optimization, and In Vitro–In Vivo Assessment DOI Creative Commons
Snehal Shinde, Anil Kumar Singh, Vijay R. Chidrawar

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 594 - 594

Published: April 18, 2025

Background: Conventional approaches in treating psoriasis demonstrate several complications. methotrexate (MTX) has been frequently used for its efficacy managing moderate to severe psoriasis. However, MTX acts as an antagonist regular dosage, which creates a patient compliance issue with undesirable consequences patients, necessitates development of innovative approach enhance skin permeation. Therefore, this study examines the improved topical administration utilizing transferosome-loaded microneedle (MNs) array patch management Methods: A design experiment was assess effect phospholipid content and edge activator type on vesicle size entrapment efficiency (EE) fabricate optimize MTX. Furthermore, incorporated within MNs assessed vitro-ex vivo-in vivo parameters. Results: The morphology result revealed vesicles mean diameter 169.4 ± 0.40 nm EE 69 0.48 (%). Compared traditional formulations (MTX gel), optimized dissolving MN showed substantial increase diffusion tested over rat skin. enhanced therapeutic benefit at application site through cumulative drug release profiles suggested sustained 24 h. Moreover, experiments that exhibited higher accumulation, compared conventional formulation tested. In addition, plasma concentration measurements demonstrated reduction systemic exposure MTX, diminishing possibility intricacy while preserving localized efficacy. capability lance epidermal layers proven by histological assessments. Conclusions: Thus, is viable method delivering topically prolonged reduced toxicity.

Language: Английский

Phyto-mediated polymeric incorporated silver nano-bio-composite for improved dermal complication management: A review DOI Creative Commons
Min He, Jun Hu, J. S. Deng

et al.

Results in Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 102272 - 102272

Published: April 1, 2025

Language: Английский

Citations

0
Enhancing melanoma therapy with hydrogel microneedles DOI Creative Commons
Leilei Zhu,

Ge Qiao,

Hongwei Gao

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: April 17, 2025

Melanoma is highly invasive and resistant to conventional treatments, accounting for nearly 75% of skin cancer-related deaths globally. Traditional therapies, such as chemotherapy immunotherapy, often exhibit limited efficacy are associated with significant side effects due systemic drug exposure. Microneedles (MNs), an emerging delivery system, offer multiple advantages, including safety, painlessness, minimal invasiveness, controlled release. Among these, hydrogel microneedles (HMNs) stand out their extracellular matrix-like structure swelling-induced continuous channels, which enable the direct therapeutic agents into tumor microenvironment (TME). This approach enhances bioavailability while reducing toxicity, establishing HMNs a promising platform melanoma treatment. review highlights recent advancements in therapy, focusing on applications biomarker extraction early diagnosis role supporting multimodal treatment strategies, chemotherapy, phototherapy, targeted combination therapy. Furthermore, current matrix materials fabrication techniques discussed. Finally, limitations critically analyzed, recommendations future research development provided.

Language: Английский

Citations

0
Enhanced Topical Delivery of Methotrexate via Transferosome-Loaded Microneedle Array Patch: Formulation, Optimization, and In Vitro–In Vivo Assessment DOI Creative Commons
Snehal Shinde, Anil Kumar Singh, Vijay R. Chidrawar

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 594 - 594

Published: April 18, 2025

Background: Conventional approaches in treating psoriasis demonstrate several complications. methotrexate (MTX) has been frequently used for its efficacy managing moderate to severe psoriasis. However, MTX acts as an antagonist regular dosage, which creates a patient compliance issue with undesirable consequences patients, necessitates development of innovative approach enhance skin permeation. Therefore, this study examines the improved topical administration utilizing transferosome-loaded microneedle (MNs) array patch management Methods: A design experiment was assess effect phospholipid content and edge activator type on vesicle size entrapment efficiency (EE) fabricate optimize MTX. Furthermore, incorporated within MNs assessed vitro-ex vivo-in vivo parameters. Results: The morphology result revealed vesicles mean diameter 169.4 ± 0.40 nm EE 69 0.48 (%). Compared traditional formulations (MTX gel), optimized dissolving MN showed substantial increase diffusion tested over rat skin. enhanced therapeutic benefit at application site through cumulative drug release profiles suggested sustained 24 h. Moreover, experiments that exhibited higher accumulation, compared conventional formulation tested. In addition, plasma concentration measurements demonstrated reduction systemic exposure MTX, diminishing possibility intricacy while preserving localized efficacy. capability lance epidermal layers proven by histological assessments. Conclusions: Thus, is viable method delivering topically prolonged reduced toxicity.

Language: Английский

Citations

0