Hydrogels in Contraceptive Applications and Their Mechanisms of Action DOI Creative Commons
Kyla M Raoult, Bert Klumperman

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: June 3, 2025

The prevention of unplanned pregnancies is a global problem that requires immediate attention. livelihoods both men and women are affected by this issue. best way to prevent means contraception. majority contraceptive options currently available target female contraception, with men's mostly limited condoms vasectomies. A relatively unexplored solution the use hydrogels in applications. Hydrogels water-insoluble polymer networks have ability absorb water and, once swollen, start mimic structure flexibility natural tissue. been used multitude biomedical applications for reason. purpose review explore some hydrogel systems designed purpose, placing emphasis on mechanisms action provide Understanding behind contraceptives allows design development new methods improvement existing formulations. purposes again child-bearing half couple; however, growing field research unexplored, technologies being investigated might soon find their market. promising

Language: Английский

The Utilization of Biopolymer Hydrogels to Encapsulate and Protect Probiotics in Foods DOI
Great Iruoghene Edo, Alice Njolke Mafe, Patrick Othuke Akpoghelie

et al.

Process Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

4
Smart Poly(N-isopropylacrylamide)-Based Hydrogels: A Tour D’horizon of Biomedical Applications DOI Creative Commons

Soumya Narayana,

B.H. Jaswanth Gowda, Umme Hani

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 207 - 207

Published: March 15, 2025

Hydrogels are innovative materials characterized by a water-swollen, crosslinked polymeric network capable of retaining substantial amounts water while maintaining structural integrity. Their unique ability to swell or contract in response environmental stimuli makes them integral biomedical applications, including drug delivery, tissue engineering, and wound healing. Among these, “smart” hydrogels, sensitive such as pH, temperature, light, showcase reversible transitions between liquid semi-solid states. Thermoresponsive exemplified poly(N-isopropylacrylamide) (PNIPAM), particularly notable for their sensitivity temperature changes, transitioning near lower critical solution (LCST) approximately 32 °C water. Structurally, PNIPAM-based hydrogels (PNIPAM-HYDs) chemically versatile, allowing modifications that enhance biocompatibility functional adaptability. These properties enable application diverse therapeutic areas cancer therapy, phototherapy, healing, engineering. In this review, the behavior smart PNIPAM explored, with an emphasis on synthesis methods brief note biocompatibility. Furthermore, PNIPAM-HYDs detailed, along applications skin conditions, ocular diseases, etc. Various delivery routes patents highlighting advancements also examined. Finally, future prospects remain promising, ongoing research focused enhancing stability, responsiveness, clinical applicability. continued development is expected revolutionize technologies, paving way more efficient targeted solutions.

Language: Английский

Citations

1
Applications of Hydrogels in Emergency Therapy DOI Creative Commons
Mariana Chelu, Mónica Popa,

José María Calderón Moreno

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 234 - 234

Published: March 23, 2025

Interest in developing new, effective materials for emergency hemostasis and wound healing is steadily increasing, particularly use emergency, surgical, military situations. Hydrogels, with their unique retention, swelling, biocompatibility properties, have emerged as essential therapy. This review provides a comprehensive examination of recent hydrogel applications acute medical scenarios, including hemostasis, management, drug delivery, soft tissue replacement, engineering. We discuss the physicochemical properties that make hydrogels suitable rapid response situations, such tunable mechanical strength, adhesiveness, responsiveness to environmental stimuli, ability encapsulate release therapeutic agents. Additionally, article explores advancements smart self-healing antimicrobial providing insights into potential revolutionize care increase survival rates both civilian applications. Through critical evaluation current clinical trials practical deployments, this highlights successes challenges faced integrating protocols, roadmap future research development dynamic field.

Language: Английский

Citations

0
Removal of cobalt and nickel ions from aqueous solution via batch adsorption technique using cost-effective β-cyclodextrin based smart hydrogel DOI

Neha Chaurasiya,

Poorn Prakash Pande,

Arbind Chaurasiya

et al.

International Journal of Environmental & Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 24

Published: March 24, 2025

Language: Английский

Citations

0
Insights into Liposomal and Gel-Based Formulations for Dermatological Treatments DOI Creative Commons
Giovanni Strazzabosco,

A Liboni,

Giulia Pezzi

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 245 - 245

Published: March 26, 2025

Dermatological diseases pose a significant challenge due to their chronic nature, complex pathophysiology, and the need for effective, patient-friendly treatments. Recent advancements in liposomal gel-based formulations have played crucial role improving drug delivery, therapeutic efficacy, patient compliance. Liposomal garnered considerable attention dermatology ability encapsulate both hydrophilic lipophilic compounds, enabling controlled release enhanced skin penetration. However, challenges such as formulation complexity, stability issues, regulatory constraints remain. Similarly, are widely used ease of application, biocompatibility, retain active ingredients. they also face limitations, including restricted penetration depth, susceptibility microbial contamination, achieving sustained release. The integration technologies offers promising strategy overcome current optimize dermatological delivery. This review explores well-established therapies recent innovations, offering comprehensive overview applications treatment prevalent conditions. Ultimately, continued research is essential refine these formulations, expanding clinical utility enhancing effectiveness dermatology.

Language: Английский

Citations

0
Stimuli-responsive hydrogels derived from agricultural residues: an overview DOI
Naglaa Salem El‐Sayed, Tamer Y.A. Fahmy, Samir Kamel

et al.

Chemical Papers, Journal Year: 2025, Volume and Issue: unknown

Published: March 29, 2025

Citations

0
Self-Assembling Peptide Hydrogels: Design, Mechanisms, Characterization, and Biomedical Applications DOI
Zhenhong Zhang, Jinhong Gao, Libo Yuan

et al.

Soft Matter, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Structural characteristics, molecular driving forces, and medical applications of multifunctional peptide-based biomaterial hydrogels.

Language: Английский

Citations

0
Hydrogels of levan polysaccharide: A systematic review DOI

A. Tekin,

Selay Tornacı,

Defne Boyacı

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 315, P. 144430 - 144430

Published: May 21, 2025

Language: Английский

Citations

0
Injectable Biopolymer-Based Hydrogels: A Next-Generation Platform for Minimally Invasive Therapeutics DOI Creative Commons
Nargish Parvin, Sang Woo Joo, Tapas Kumar Mandal

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(6), P. 383 - 383

Published: May 23, 2025

Injectable biopolymer-based hydrogels have emerged as a powerful class of biomaterials designed for minimally invasive therapeutic strategies in modern medicine. These smart hydrogels, derived from natural biopolymers, such alginate, chitosan, gelatin, hyaluronic acid, and collagen, offer unique advantages, including biocompatibility, biodegradability, the ability to mimic extracellular matrix. This review provides comprehensive overview recent advancements design, crosslinking mechanisms, biofunctionality injectable tailored targeted drug delivery tissue regeneration. Special attention is given their role situ gelling systems, cancer therapy, musculoskeletal repair, neural Challenges related mechanical strength, degradation control, clinical translation are also discussed, along with future perspectives scalable manufacturing regulatory approval.

Language: Английский

Citations

0
Dynamic Hydrogels with Tunable Mechanics for 3D Organoid Derivation DOI

Xueyong Xie,

Xuewen Chen, Jian Zhou

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: May 28, 2025

Abstract The mechanical properties of the hydrogel play a pivotal role in governing formation and development 3D organoids vitro. However, commonly employed natural hydrogels, such as Matrigel other extracellular matrix (ECM)‐derived products, are characterized by ill‐defined complex compositions, resulting non‐tunable properties. This limitation poses challenges controlling organoids' developmental trajectory morphology. Although numerous synthetic hydrogels with well‐defined chemical structures have recently been adopted to study modulating stiffness, advanced research emphasizes importance dynamic cues, stiffness softening viscoelasticity, for optimal organoid derivation. These cues essential mimicking physiological states during their growth. Despite potential, concept is often used interchangeably, systematic review lacking clarify this ambiguity. Furthermore, mechanisms through which regulate not thoroughly reported. endeavors summarize categorize reveal effects mechanics on Additionally, prospects derivation deliberated promote more rational design guiding propelling technology biomedicine.

Language: Английский

Citations

0