Immunomodulatory and Anti-Inflammatory Properties of Honey and Bee Products DOI Creative Commons
Bashar Saad

Immuno, Journal Year: 2025, Volume and Issue: 5(2), P. 19 - 19

Published: May 30, 2025

Honey and other bee products, including propolis, royal jelly, pollen, are widely recognized for their medicinal properties. Among numerous biological activities, anti-inflammatory immunomodulatory effects have gained significant attention in recent years. Immune inflammatory disorders contribute significantly to the development of chronic conditions, cancer diabetes. Bee-derived along with bioactive compounds such as polyphenols, shown promising therapeutic modulating mediators. Studies indicate that these products help regulate tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), interleukin-7 (IL-7) levels while reducing reactive oxygen species (ROS) production. Additionally, both vitro vivo research, clinical studies, highlight role enhancing immune responses by activating B T lymphocytes. This review explores molecular mechanisms underlying properties, emphasizing flavonoids, phenolic acids, proteins inflammation. Evidence from vitro, vivo, studies suggests honey influence cytokine production, cell activity, mitigate oxidative stress, making them potential agents immune-related disorders. To gather relevant information, databases Google Scholar, PubMed, ScienceDirect were searched using various keyword combinations, immunomodulatory, anti-inflammatory, honey, venom, pollen. Given immune-protective, antioxidant, anti-apoptotic, antimicrobial remain a subject interest further evaluation.

Language: Английский

Selected honey as a multifaceted antimicrobial agent: review of compounds, mechanisms, and research challenges DOI
António Machado, Duarte Toubarro, José Baptista

et al.

Future Microbiology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 22

Published: April 28, 2025

Honey, derived from floral nectar, has been valued for its nutritional and therapeutic properties, with recent studies emphasizing broad-spectrum antimicrobial potential, especially against resistance (AMR). Honey's activity stems unique composition, including high sugar content, low pH, bioactive compounds like hydrogen peroxide, methylglyoxal (MGO), phenolic compounds. Distinct honey types, such as Manuka, Sidr, Tualang, demonstrate varying effects based on their botanical geographical origins. Manuka honey, rich in MGO, is notably effective multidrug-resistant pathogens, while Sidr heather honeys excel biofilm inhibition antioxidative properties. Bioactive components, phenolics, flavonoids, enzymes, peptides, disrupt microbial membranes, inhibit metabolic pathways, induce oxidative stress. Advanced analytical techniques HPLC GC-MS have identified these compounds, though gaps remain understanding secondary metabolites synergistic actions. This review highlights honey's potential a sustainable resource, the need standardization, clinical validation, interdisciplinary research. Honey represents promising solution to AMR offers opportunities integration into modern medicine healthcare strategies.

Language: Английский

Citations

0
Immunomodulatory and Anti-Inflammatory Properties of Honey and Bee Products DOI Creative Commons
Bashar Saad

Immuno, Journal Year: 2025, Volume and Issue: 5(2), P. 19 - 19

Published: May 30, 2025

Honey and other bee products, including propolis, royal jelly, pollen, are widely recognized for their medicinal properties. Among numerous biological activities, anti-inflammatory immunomodulatory effects have gained significant attention in recent years. Immune inflammatory disorders contribute significantly to the development of chronic conditions, cancer diabetes. Bee-derived along with bioactive compounds such as polyphenols, shown promising therapeutic modulating mediators. Studies indicate that these products help regulate tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), interleukin-7 (IL-7) levels while reducing reactive oxygen species (ROS) production. Additionally, both vitro vivo research, clinical studies, highlight role enhancing immune responses by activating B T lymphocytes. This review explores molecular mechanisms underlying properties, emphasizing flavonoids, phenolic acids, proteins inflammation. Evidence from vitro, vivo, studies suggests honey influence cytokine production, cell activity, mitigate oxidative stress, making them potential agents immune-related disorders. To gather relevant information, databases Google Scholar, PubMed, ScienceDirect were searched using various keyword combinations, immunomodulatory, anti-inflammatory, honey, venom, pollen. Given immune-protective, antioxidant, anti-apoptotic, antimicrobial remain a subject interest further evaluation.

Language: Английский

Citations

0