Electrospun Chitosan-Coated Recycled PET Scaffolds for Biomedical Applications: Short-Term Antimicrobial Efficacy and In Vivo Evaluation DOI Open Access

Andreea Mihaela Grămadă,

Adelina-Gabriela Niculescu, Alexandra Cătălina Bîrcă

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(8), P. 1077 - 1077

Published: April 16, 2025

This study investigates the preparation of electrospun recycled polyethylene terephthalate (rPET) coated with chitosan (CS) and evaluates their antibiofilm properties in vivo response. rPET scaffolds were first fabricated via electrospinning at different flow rates (10, 7.5, 5 2.5 mL/h) subsequently chitosan. Scanning electron microscopy (SEM) revealed that fiber morphology varied parameters, influencing microbial adhesion. Antimicrobial tests demonstrated rPET@CS significantly inhibited Staphylococcus aureus, Pseudomonas aeruginosa Candida albicans biofilm formation compared to control uncoated surfaces. Subcutaneous implantation induced a transient inflammatory response, macrophage recruitment collagen deposition supporting tissue integration. These findings highlight potential as sustainable antimicrobial biomaterials for applications infection-resistant coatings biomedical implants.

Language: Английский

Electrospun Chitosan-Coated Recycled PET Scaffolds for Biomedical Applications: Short-Term Antimicrobial Efficacy and In Vivo Evaluation DOI Open Access

Andreea Mihaela Grămadă,

Adelina-Gabriela Niculescu, Alexandra Cătălina Bîrcă

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(8), P. 1077 - 1077

Published: April 16, 2025

This study investigates the preparation of electrospun recycled polyethylene terephthalate (rPET) coated with chitosan (CS) and evaluates their antibiofilm properties in vivo response. rPET scaffolds were first fabricated via electrospinning at different flow rates (10, 7.5, 5 2.5 mL/h) subsequently chitosan. Scanning electron microscopy (SEM) revealed that fiber morphology varied parameters, influencing microbial adhesion. Antimicrobial tests demonstrated rPET@CS significantly inhibited Staphylococcus aureus, Pseudomonas aeruginosa Candida albicans biofilm formation compared to control uncoated surfaces. Subcutaneous implantation induced a transient inflammatory response, macrophage recruitment collagen deposition supporting tissue integration. These findings highlight potential as sustainable antimicrobial biomaterials for applications infection-resistant coatings biomedical implants.

Language: Английский

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