New injectable chitosan-hyaluronic acid based hydrogels for hemostasis and wound healing

Carbohydrate Polymers, Journal Year: 2022, Volume and Issue: 294, P. 119767 - 119767

Published: June 23, 2022

Language: Английский

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Advancements in the Use of Hydrogels for Regenerative Medicine: Properties and Biomedical Applications

International Journal of Biomaterials, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 16

Published: Nov. 7, 2022

Due to their particular water absorption capacity, hydrogels are the most widely used scaffolds in biomedical studies regenerate damaged tissue. Hydrogels can be tissue engineering design for three-dimensional cell culture, providing a novel alternative traditional two-dimensional culture as have biomimetic structure. This material property is crucial regenerative medicine, especially nervous system, since it highly complex and delicate move quickly within human body without physically disturbing environment possess essential biocompatible properties, well ability form mimetic scaffold situ. Therefore, perfect candidates applications. represent potential regenerating lost after removing brain tumor and/or injuries. reason presents them an exciting physiological problems, such injuries central system neurodegenerative disease.

Language: Английский

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Hydrogels and Wound Healing: Current and Future Prospects

Gels, Journal Year: 2024, Volume and Issue: 10(1), P. 43 - 43

Published: Jan. 5, 2024

The care and rehabilitation of acute chronic wounds have a significant social economic impact on patients global health. This burden is primarily due to the adverse effects infections, prolonged recovery, associated treatment costs. Chronic can be treated with variety approaches, which include surgery, negative pressure wound therapy, dressings, hyperbaric oxygen therapy. However, each these strategies has an array limitations. existing dry dressings lack functionality in promoting healing exacerbating pain by adhering wound. Hydrogels, are commonly polymer-based swell water, been proposed as potential remedies their ability provide moist environment that facilitates healing. Their unique composition enables them absorb exudates, exhibit shape adaptability, modified incorporate active compounds such growth factors antibacterial compounds. review provides updated discussion leading natural synthetic hydrogels utilized healing, details latest advancements hydrogel technology, explores alternate approaches this field. Search engines Scopus, PubMed, Science Direct, Web were advances applications over last fifteen years.

Language: Английский

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Chitosan-based self-healing hydrogel dressing for wound healing

Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 332, P. 103267 - 103267

Published: Aug. 3, 2024

Language: Английский

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Biomedical applications of functional hydrogels: Innovative developments, relevant clinical trials and advanced products

Biomaterials, Journal Year: 2024, Volume and Issue: 312, P. 122718 - 122718

Published: July 27, 2024

Functional hydrogels are used for numerous biomedical applications such as tissue engineering, wound dressings, lubricants, contact lenses and advanced drug delivery systems. Most of them based on synthetic or natural polymers forming a three-dimensional network that contains aqueous media. Among polymers, poly(meth)acrylates, polyethyleneglycols, poly(vinylalcohols), poly(vinylpyrrolidones), PLGA poly(urethanes) high relevance, whereas mainly polysaccharides hyaluronic acid, alginate chitosan proteins albumin, collagen elastin. In contrast to most biodegradable. Both often chemically modified in order improve induce favorable properties functions like mechanical strength, stiffness, elasticity, porosity, adhesive properties, situ gelling water binding capacity release controlling properties. Within this review we provide an overview about the broad spectrum functional hydrogels, summarize innovative approaches, discuss concept relevant clinical trials highlight products examples successful developments.

Language: Английский

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Hydrogels in Cutaneous Wound Healing: Insights into Characterization, Properties, Formulation and Therapeutic Potential

Gels, Journal Year: 2024, Volume and Issue: 10(3), P. 188 - 188

Published: March 8, 2024

Hydrogels are polymeric materials that possess a set of characteristics meeting various requirements an ideal wound dressing, making them promising for care. These features include, among others, the ability to absorb and retain large amounts water capacity closely mimic native structures, such as extracellular matrix, facilitating cellular processes like proliferation differentiation. The polymers used in hydrogel formulations exhibit broad spectrum properties, allowing be classified into two main categories: natural collagen chitosan, synthetic polyurethane polyethylene glycol. This review offers comprehensive overview critical analysis key can constitute hydrogels, beginning with brief contextualization polymers. It delves their function, origin, chemical structure, highlighting sources extraction obtaining. Additionally, this encompasses intrinsic properties these roles healing process, accompanied, whenever available, by explanations underlying mechanisms action. also addresses limitations describes some studies on effectiveness isolated promoting skin regeneration healing. Subsequently, we briefly discuss application strategies hydrogels derived from potential promote process. achieved due role stimulation angiogenesis, example, or through incorporation substances growth factors drugs, antimicrobials, imparting new hydrogels. In addition substance incorporation, is related serve three-dimensional matrix cell culture, whether it involves loading cells recruiting site, where they proliferate scaffold form tissue. latter strategy presupposes biosensors real-time monitoring conditions, temperature pH. Future prospects then ultimately addressed. As far aware, manuscript represents first approach brings together critically analyzes fundamental aspects both constituting context cutaneous will foundational point future studies, aiming contribute development effective environmentally friendly dressing wounds.

Language: Английский

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Advancing burn wound treatment: exploring hydrogel as a transdermal drug delivery system

Drug Delivery, Journal Year: 2024, Volume and Issue: 31(1)

Published: Feb. 16, 2024

Burn injuries are prevalent and life-threatening forms that contribute significantly to mortality rates due associated wound infections. The management of burn wounds presents substantial challenges. Hydrogel exhibits tremendous potential as an ideal alternative traditional dressings such gauze. This is primarily attributed its three-dimensional (3D) crosslinked polymer network, which possesses a high water content, fostering moist environment supports effective healing. Additionally, hydrogel facilitates the penetration loaded therapeutic agents throughout surface, combating pathogens through hydration effect thereby enhancing healing process. However, presence eschar formation on obstructs passive diffusion therapeutics, impairing efficacy dressing, particularly in cases severe burns involving deeper tissue damage. review focuses exploring carrier for transdermal drug delivery treatment. Furthermore, strategies aimed at from optimize also discussed.

Language: Английский

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Therapeutic Potential of Microneedle Assisted Drug Delivery for Wound Healing: Current State of the Art, Challenges, and Future Perspective

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 8, 2025

Language: Английский

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Hydrogels for Wound Dressings: Applications in Burn Treatment and Chronic Wound Care

Journal of Composites Science, Journal Year: 2025, Volume and Issue: 9(3), P. 133 - 133

Published: March 13, 2025

Severe skin injuries such as burns and chronic wounds are a subject of interest in the medical field, they require much attention. These types susceptible to serious complications, which can worsen health patients reduce their quality life. Hydrogels have emerged innovative wound dressings for treating acute wounds, including burns, diabetic foot ulcers, venous leg pressure ulcers. polymeric networks provide moist environment, promote cellular migration, offer antimicrobial properties, being recognized superior conventional dressings. This review aims explore recent advancements hydrogel-based dressings, emphasizing state-of-the-art technologies used this purpose trend achieving personalized therapeutic approaches. Despite promising vitro vivo findings described review, further clinical validation large-scale manufacturing optimizations required widespread adoption.

Language: Английский

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In Vitro and In Vivo Characterization Methods for Evaluation of Modern Wound Dressings

Pharmaceutics, Journal Year: 2022, Volume and Issue: 15(1), P. 42 - 42

Published: Dec. 22, 2022

Chronic wound management represents a major challenge in the healthcare sector owing to its delayed wound-healing process progression and huge financial burden. In this regard, dressings provide an appropriate platform for facilitating healing several decades. However, adherent traditional do not effective highly exudating chronic wounds need development of newer innovative facilitate accelerated healing. addition, these frequent changing, resulting more pain discomfort. order overcome issues, wide range affordable modern have been developed explored recently accelerate improve process. comprehensive understanding various vitro vivo characterization methods being utilized evaluation different is lacking. context, overview their complete assessment provided review. Herein, emerging with advantages challenges also reviewed. Furthermore, assays models rate using are discussed detail. Finally, summary future outlook highlighted.

Language: Английский

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