Biomedical Materials,
Journal Year:
2024,
Volume and Issue:
20(1), P. 015010 - 015010
Published: Nov. 13, 2024
Early
thrombosis
following
coronary
artery
bypass
grafting
(CABG)
surgery
leads
to
perioperative
myocardial
infarction,
which
causes
difficulties
for
clinicians
and
patients.
Moreover,
once
infarction
occurs,
the
mortality
rate
is
extremely
high.
In
recent
years,
microneedle
(MN)
drug
delivery
systems
have
become
a
research
hotspot
with
broad
clinical
application
prospects.
These
are
capable
of
achieving
sustained,
safe,
painless
local
release.
cardiovascular
applications,
MNs
maximize
anticoagulant
effects,
inhibit
endometrial
hyperplasia,
reduce
systemic
side
effects.
We
speculate
that
MN
system
can
be
used
target
transplanted
veins
their
incidence
after
CABG
surgery.
Therefore,
this
study
developed
hyaluronic
acid
patch
loaded
tirofiban
conducted
preliminary
physicochemical
tests.
The
safety,
efficacy,
biocompatibility,
targeting
were
evaluated
using
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(2), P. 237 - 237
Published: Feb. 6, 2024
Microneedle
(MN)
technology
is
an
optimal
choice
for
the
delivery
of
drugs
via
transdermal
route,
with
a
minimally
invasive
procedure.
MN
applications
are
varied
from
drug
delivery,
cosmetics,
tissue
engineering,
vaccine
and
disease
diagnostics.
The
biomedical
device
that
offers
many
advantages
including
but
not
limited
to
painless
experience,
being
time-effective,
real-time
sensing.
This
research
implements
additive
manufacturing
(AM)
fabricate
arrays
advanced
therapeutic
applications.
Stereolithography
(SLA)
was
used
six
designs
three
aspect
ratios.
array
included
conical-shaped
100
needles
(10
×
10
needle)
in
each
array.
microneedles
were
characterized
using
optical
scanning
electron
microscopy
evaluate
dimensional
accuracy.
Further,
mechanical
insertion
tests
performed
analyze
strength
skin
penetration
capabilities
polymeric
MN.
MNs
higher
ratios
had
deformation
characteristics
suitable
deeper
levels
beyond
stratum
corneum.
both
0.3
mm
0.4
base
diameters
displayed
consistent
force–displacement
behavior
during
skin-equivalent
test.
establishes
guidelines
fabricating
high-accuracy
low-cost
3D
printing.
Sensors & Diagnostics,
Journal Year:
2024,
Volume and Issue:
3(6), P. 893 - 913
Published: Jan. 1, 2024
This
manuscript
emphasizes
advancements
in
electrochemical
sensors
for
real-time
glucose
monitoring,
showcasing
their
pivotal
role
enhancing
personalized
healthcare
through
continuous,
reliable
measurement
of
biochemical
markers.
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(3), P. 1682 - 1693
Published: Feb. 9, 2024
Microneedle-based
drug
delivery
offers
an
attractive
and
minimally
invasive
administration
route
to
deliver
therapeutic
agents
through
the
skin
by
bypassing
stratum
corneum,
main
barrier.
Recently,
hydrogel-based
microneedles
have
gained
prominence
for
their
exceptional
ability
precisely
control
release
of
cargo.
In
this
study,
we
investigated
feasibility
fabricating
from
triblock
amphiphiles
with
linear
poly(ethylene
glycol)
(PEG)
as
hydrophilic
middle
block
two
dendritic
side-blocks
enzyme-cleavable
hydrophobic
end-groups.
Due
poor
formation
brittleness
made
neat
amphiphile,
added
a
sodium
alginate
base
layer
tested
different
polymeric
excipients
enhance
mechanical
strength
microneedles.
Following
optimization,
based
on
were
successfully
fabricated
exhibited
favorable
insertion
efficiency
low
height
reduction
percentage
when
in
Parafilm
skin-simulant
model.
When
against
static
forces
ranging
50
1000
g
(4.9–98
mN/needle),
showed
adequate
no
fractures
or
broken
segments.
buffer
solution,
solid
swelled
into
hydrogel
within
about
30
s,
followed
rapid
disintegration
small
particles.
These
particles
could
undergo
slow
enzymatic
degradation
soluble
polymers.
vitro
study
dexamethasone
(DEX),
steroid
model
drug,
first-order
release,
90%
released
6
days.
Eventually,
DEX-loaded
MNs
subjected
test
using
chicken
full
penetration.
This
demonstrates
programming
hydrogel-forming
several
mesophase
transitions
potential
application
system
self-administration,
increased
patient
compliance,
improved
efficacy,
sustained
release.
ACS Biomaterials Science & Engineering,
Journal Year:
2024,
Volume and Issue:
10(8), P. 4771 - 4790
Published: July 10, 2024
Microneedles
are
a
novel
drug
delivery
system
that
offers
advantages
such
as
safety,
painlessness,
minimally
invasive
administration,
simplicity
of
use,
and
controllable
delivery.
As
type
polymer
microneedle
with
three-dimensional
network
structure,
hydrogel
microneedles
(HMNs)
possess
excellent
biocompatibility
biodegradability
encapsulate
various
therapeutic
drugs
while
maintaining
activity,
thus
attracting
significant
attention.
Recently,
they
have
been
widely
employed
to
promote
wound
healing
demonstrated
favorable
effects.
Although
there
reviews
about
HMNs,
few
them
focus
on
management.
Herein,
we
present
comprehensive
overview
the
design
preparation
methods
particular
emphasis
their
application
status
in
healing,
including
acute
infected
diabetic
scarless
healing.
Finally,
examine
limitations
HMNs
management
provide
suggestions
for
future
research
directions.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(1), P. 124 - 124
Published: Jan. 17, 2025
The
application
of
dissolving
microneedle
arrays
(DMNAs)
is
an
emerging
trend
in
drug
and
vaccine
delivery
as
alternative
for
hypodermic
needles
or
other
less
convenient
administration
methods.
major
benefits
include,
amongst
others,
that
no
trained
healthcare
personnel
required
the
recipient
experiences
hardly
any
pain
during
administration.
However,
a
successful
from
DMNA,
microneedles
should
be
inserted
intact
into
skin.
A
penetration
upper
skin
layers
may
challenging
because
elastic
nature
skin;
therefore,
minimum
insertion
force
to
overcome
total
resistance
In
addition,
need
stay
intact,
which
requires
certain
mechanical
strength,
able
resist
force.
addition
type
material
with
DMNAs
are
produced,
geometry
will
also
have
profound
effect,
not
only
on
strength
but
number
insertions
depth
this
review,
effects
shape,
aspect
ratio,
length,
width
base,
tip
diameter
angle,
spacing
aforementioned
effect
parameters
were
evaluated
answer
following
question:
‘What
optimal
arrays?’.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 10, 2025
Abstract
The
skin
microenvironment
is
a
highly
intricate
and
dynamic
system,
characterized
by
an
acidic
pH,
diverse
microbiota,
various
metabolites,
numerous
enzymes,
creating
both
challenges
opportunities
for
the
development
of
innovative
drug
delivery
systems.
Dissolving
Microneedles
(MNs)
have
emerged
as
promising,
pain‐free
alternative
to
conventional
invasive
injections,
offering
ability
deliver
therapeutics
through
gradual
degradation
within
skin's
interstitial
fluids.
Building
upon
unique
properties
dissolving
MNs,
novel
concept
introduced
wherein
MNs
serve
in
situ
chemical
reaction
chambers.
In
this
framework,
can
reactants
or
catalysts
skin,
enabling
initiation
specific
reactions,
such
prodrug
activation
targeted
therapy,
harmful
enhanced
synthesis
beneficial
molecules.
Moreover,
review
systematically
explores
potential
chambers,
discussing
key
aspects
their
sustained
release
mechanisms,
design
strategies,
range
therapeutic
applications.
Finally,
forward‐looking
perspective
provided
on
future
addressing
broader
clinical
translation
application
personalized
medicine.
Colorants,
Journal Year:
2025,
Volume and Issue:
4(1), P. 8 - 8
Published: Feb. 19, 2025
The
use
of
indigo
carmine
dye
in
the
textile
industry,
particularly
denim
production,
presents
a
significant
sustainability
challenge
due
to
large
amounts
wastewater
generated
by
this
process,
since
fabric
is
one
most
produced
around
world.
In
order
face
challenges
like
this,
effluent
treatment
using
polymeric
materials
has
become
an
area
intense
research.
study,
we
developed
eco-friendly
hydrogel
based
on
oligoglycerol-malic
acid
polyester
crosslinked
with
citric
acid,
which
was
applied
adsorb
carmine.
properties
and
its
precursors
were
analyzed
spectroscopic,
thermal,
morphologic
techniques.
demonstrated
water
uptake
capacity
up
187%
own
mass
adsorbed
approximately
73%
after
24
h
contact.
Tests
conducted
presence
sodium
chloride
indicated
that
salt
impairs
adsorption
process.
Additionally,
kinetics
isotherms
evaluated
followed
pseudo-second-order
model,
indicating
chemisorption
Langmuir
isotherm,
consistent
monolayer
adsorption.
These
results
emphasize
potential
for
removing
application
industry
treatment,
aiming
minimize
environmental
impacts.
