Gels,
Journal Year:
2024,
Volume and Issue:
10(11), P. 745 - 745
Published: Nov. 15, 2024
Osteochondral
(OC)
tissue
plays
a
crucial
role
due
to
its
ability
connect
bone
and
cartilage
tissues.
To
address
the
complexity
of
structure
functionality
at
bone-cartilage
interface,
relevant
presence
tidemark
as
critical
element
boundary,
we
fabricated
graded
scaffolds
through
sequential
3D
printing.
The
scaffold's
bottom
layer
was
based
on
gelatin/oxidized
alginate
mixture
enriched
with
hydroxyapatite
(HAp)
create
rougher
surface
larger
pores
promote
osteogenesis.
In
contrast,
upper
engineered
have
smaller
aimed
formation
mimic
physical
properties
cartilage.
An
electrospun
ε-polycaprolactone
(PCL)
membrane
micrometer-range
incorporated
between
layers
replicate
function
tidemark-a
barrier
prevent
vascularization
from
subchondral
tissue.
vitro
cell
studies
confirmed
viability
cells
PCL
mesh
cellular
migration.
were
thoroughly
characterized,
their
mechanical
compared
native
OC
tissue,
demonstrating
suitability
for
engineering
graft
modeling.
distance
gradient
mineral
concentration
found
be
151
µm
grafts
interface.
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(3), P. 275 - 275
Published: Feb. 25, 2024
Calcification
is
a
process
of
accumulation
calcium
in
tissues
and
deposition
salts
by
the
crystallization
PO43−
ionized
(Ca2+).
It
crucial
development
bones
teeth.
However,
pathological
calcification
can
occur
almost
any
soft
tissue
organism.
The
better
studied
vascular
calcification,
where
accumulate
intima
or
medial
layer
aortic
valves,
it
associated
with
higher
mortality
cardiovascular
events,
including
myocardial
infarction,
stroke,
peripheral
artery
disease
(PAD),
diabetes
chronic
kidney
(CKD),
among
others.
involves
an
intricate
interplay
different
cellular
components,
endothelial
cells
(ECs),
smooth
muscle
(VSMCs),
fibroblasts,
pericytes,
concurrent
activation
several
signaling
pathways,
calcium,
Wnt,
BMP/Smad,
Notch,
regulation
molecular
mediators,
growth
factors
(GFs),
osteogenic
matrix
vesicles
(MVs).
In
present
review,
we
aim
to
explore
players,
biomarkers,
clinical
treatment
strategies
provide
current
comprehensive
overview
topic.
Gels,
Journal Year:
2024,
Volume and Issue:
10(11), P. 693 - 693
Published: Oct. 25, 2024
Hydrogels
are
known
for
their
high
water
retention
capacity
and
biocompatibility
have
become
essential
materials
in
tissue
engineering
drug
delivery
systems.
This
review
explores
recent
advancements
hydrogel
technology,
focusing
on
innovative
types
such
as
self-healing,
tough,
smart,
hybrid
hydrogels,
each
engineered
to
overcome
the
limitations
of
conventional
hydrogels.
Self-healing
hydrogels
can
autonomously
repair
structural
damage,
making
them
well-suited
applications
dynamic
biomedical
environments.
Tough
designed
with
enhanced
mechanical
properties,
enabling
use
load-bearing
cartilage
regeneration.
Smart
respond
external
stimuli,
including
changes
pH,
temperature,
electromagnetic
fields,
ideal
controlled
release
tailored
specific
medical
needs.
Hybrid
made
from
both
natural
synthetic
polymers,
combine
bioactivity
resilience,
which
is
particularly
valuable
complex
tissues.
Despite
these
innovations,
challenges
optimizing
biocompatibility,
adjusting
degradation
rates,
scaling
up
production
remain.
provides
an
in-depth
analysis
emerging
technologies,
highlighting
transformative
potential
while
outlining
future
directions
development
applications.
Materials,
Journal Year:
2024,
Volume and Issue:
17(19), P. 4792 - 4792
Published: Sept. 29, 2024
Hydrogels,
known
for
their
unique
ability
to
retain
large
amounts
of
water,
have
emerged
as
pivotal
materials
in
both
tissue
engineering
and
biosensing
applications.
This
review
provides
an
updated
comprehensive
examination
cutting-edge
hydrogel
technologies
multifaceted
roles
these
fields.
Initially,
the
chemical
composition
intrinsic
properties
natural
synthetic
hydrogels
are
discussed,
highlighting
biocompatibility
biodegradability.
The
manuscript
then
probes
into
innovative
scaffold
designs
fabrication
techniques
such
3D
printing,
electrospinning,
self-assembly
methods,
emphasizing
applications
regenerating
bone,
cartilage,
skin,
neural
tissues.
In
realm
biosensing,
hydrogels’
responsive
nature
is
explored
through
integration
optical,
electrochemical,
piezoelectric
sensors.
These
sensors
instrumental
medical
diagnostics
glucose
monitoring,
pathogen
detection,
biomarker
identification,
well
environmental
industrial
like
pollution
food
quality
monitoring.
Furthermore,
explores
cross-disciplinary
innovations,
including
use
wearable
devices,
hybrid
systems,
potential
personalized
medicine.
By
addressing
current
challenges
future
directions,
this
aims
underscore
transformative
impact
advancing
healthcare
practices,
thereby
providing
a
vital
resource
researchers
practitioners
field.
Mineral
nanoparticles
and
osteoinductive
biomaterials
are
essential
in
advancing
bone
regeneration
by
addressing
skeletal
conditions
injuries
that
compromise
structural
integrity
functionality.
These
stimulate
the
differentiation
of
precursor
cells
into
osteoblasts,
creating
biocompatible
environments
conducive
to
tissue
regeneration.
Among
most
promising
innovations,
mineral-based
nanocomposite
hydrogels
have
emerged
as
effective
strategies
for
enhancing
potential.
This
review
explores
diverse
types
biomaterials,
including
natural
sources,
synthetic
compounds,
hybrid
designs
incorporate
mineralized
nanoparticles.
Emphasis
is
placed
on
polymeric
delivery
platforms
these
materials,
highlighting
their
dual
role
supports
bioactive
agents
promote
osteogenesis.
Challenges
such
immune
rejection,
biodegradability,
mechanical
stability,
short
vivo
residence
time
critically
discussed,
alongside
impact
clinical
translation.
By
presenting
a
comprehensive
analysis
mechanisms,
applications,
limitations,
this
identifies
opportunities
integrating
with
emerging
fields
like
immunology
biomechanics.
Ultimately,
work
aims
provide
actionable
insights
advance
development
novel,
clinically
relevant
solutions
improve
patient
outcomes
address
growing
global
need
repair
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 7, 2025
Injectable
hydrogels
represent
a
highly
promising
approach
for
localized
drug
delivery
systems
(DDSs)
in
the
management
of
bone-related
conditions
such
as
osteoporosis,
osteonecrosis,
osteoarthritis,
osteomyelitis,
and
osteosarcoma.
Their
appeal
lies
their
biocompatibility,
adjustable
mechanical
properties,
capacity
to
respond
external
stimuli,
including
pH,
temperature,
light,
redox
potential,
ionic
strength,
enzymatic
activity.
These
features
enable
enhanced
targeted
bioactive
agents.
This
mini-review
evaluates
synthesis
injectable
well
recent
advancements
treating
range
bone
disorders,
focusing
on
mechanisms
sustained
DDSs
delivering
drugs,
nanoparticles,
growth
factors,
cells
(e.g.,
stem
cells).
Moreover,
it
highlights
clinical
studies
disease
treatment.
Additionally,
emphasizes
potential
synergy
between
hydrogel-based
point-of-care
technologies,
which
are
anticipated
play
pivotal
role
future
therapies.
have
transform
treatment
by
facilitating
precise,
sustained,
minimally
invasive
therapeutic
delivery.
Nevertheless,
significant
challenges,
long-term
scalability,
reproducibility,
precise
regulation
release
kinetics,
must
be
addressed
unlock
fully.
Addressing
these
challenges
will
not
only
advance
therapy
but
also
open
new
avenues
regenerative
medicine
personalized
healthcare.
Gels,
Journal Year:
2024,
Volume and Issue:
10(7), P. 451 - 451
Published: July 10, 2024
An
electrochemical
sensor
sensitive
to
coenzyme
A
(CoA)
was
designed
using
a
CoA-responsive
polyallylamine-manganese
oxide-polymer
dot
nanogel
coated
on
the
electrode
surface
detect
various
genetic
models
of
osteoarthritis
(OA).
The
responded
abundance
CoA
in
OA,
causing
breakage
MnO
