Eficacia de nuevos viscosuplementos activos en el comportamiento de un modelo experimental de osteoartritis DOI Creative Commons

R.E. Pérez Expósito,

M.A. Ortega Núñez,

Marta Varela

et al.

Revista Española de Cirugía Ortopédica y Traumatología, Journal Year: 2024, Volume and Issue: unknown

Published: April 1, 2024

Objetivo: evaluar con un modelo animal de osteoartrosis (conejos raza Nueva Zelanda) la eficacia del tratamiento viscosuplementos activos (ácido hialurónico cargado nanopartículas (NPs) que encapsulan compuestos o fármacos antiinflamatorios. Material y métodos: estudio experimental compuesto 5 grupos conejos a los se realizó sección ligamento cruzado anterior resección menisco interno para desencadenar cambios degenerativos usarlo como osteoartrosis. Los dividieron en sin (I), ácido (AH) comercial (II), AH vacías (III), dexametasona (IV) cúrcuma (V). En II V infiltración correspondiente espaciándolas una semana.Se análisis histológico macroscópico mediante escala basada clasificación Outerbridge artrosis. Resultados: Observamos dicho es reproducible aprecian similares encuentran el ser humano. infiltró cargadas curcumina (V), seguido grupo presentaron macroscópicamente menos fibrilación, exposición hueso subcondral esclerosis (mejor puntuación escala) control (I) (osteoartrosis tratamiento), (II) tratado fármaco (III). Conclusiones: El uso podría tener efecto adicional al convencional por su antioxidante antiinflamatorio, siendo más prometedor las segundo lugar dexametasona. Objective: to evaluate with an model of osteoarthritis (New Zealand rabbits) the effectiveness treatment active viscosupplements (hyaluronic acid loaded nanoparticles that encapsulate anti-inflammatory compounds or drugs. and methods: study composed groups rabbits in which section cruciate ligament resection internal meniscus were performed trigger degenerative changes use it as osteoarthritis. The divided into osteoarthrosis without commercial hyaluronic (HA) HA empty encapsulating dexamethasone curcumin In V, infiltration corresponding compound was carried out spaced one week apart.Macroscopic histological analysis using scale based on classification for Results: We observed this is similar those found humans are observed.The infiltrated curcumin-loaded followed by group presented macroscopically less fibrillation, exposure subchondral bone sclerosis (better score scale) than (osteoarthritis treatment), treated drug Conclusions: could have additional effect conventional due its antioxidant effect. most promising second encapsulates dexamethasone.

A Review of Advanced Hydrogel Applications for Tissue Engineering and Drug Delivery Systems as Biomaterials DOI Creative Commons
Hoon Choi, Wan-Sun Choi,

Jin-Oh Jeong

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(11), P. 693 - 693

Published: Oct. 25, 2024

Hydrogels are known for their high water retention capacity and biocompatibility have become essential materials in tissue engineering drug delivery systems. This review explores recent advancements hydrogel technology, focusing on innovative types such as self-healing, tough, smart, hybrid hydrogels, each engineered to overcome the limitations of conventional hydrogels. Self-healing hydrogels can autonomously repair structural damage, making them well-suited applications dynamic biomedical environments. Tough designed with enhanced mechanical properties, enabling use load-bearing cartilage regeneration. Smart respond external stimuli, including changes pH, temperature, electromagnetic fields, ideal controlled release tailored specific medical needs. Hybrid made from both natural synthetic polymers, combine bioactivity resilience, which is particularly valuable complex tissues. Despite these innovations, challenges optimizing biocompatibility, adjusting degradation rates, scaling up production remain. provides an in-depth analysis emerging technologies, highlighting transformative potential while outlining future directions development applications.

Language: Английский

Citations

12
Vascular Calcification: Molecular Networking, Pathological Implications and Translational Opportunities DOI Creative Commons
Miguel Á. Ortega,

Diego De León-Oliva,

M.J. Gimeno

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(3), P. 275 - 275

Published: Feb. 25, 2024

Calcification is a process of accumulation calcium in tissues and deposition salts by the crystallization PO43− ionized (Ca2+). It crucial development bones teeth. However, pathological calcification can occur almost any soft tissue organism. The better studied vascular calcification, where accumulate intima or medial layer aortic valves, it associated with higher mortality cardiovascular events, including myocardial infarction, stroke, peripheral artery disease (PAD), diabetes chronic kidney (CKD), among others. involves an intricate interplay different cellular components, endothelial cells (ECs), smooth muscle (VSMCs), fibroblasts, pericytes, concurrent activation several signaling pathways, calcium, Wnt, BMP/Smad, Notch, regulation molecular mediators, growth factors (GFs), osteogenic matrix vesicles (MVs). In present review, we aim to explore players, biomarkers, clinical treatment strategies provide current comprehensive overview topic.

Language: Английский

Citations

11
Application and progress of smart hydrogel microspheres for regulating oxidative stress in osteoarthritis DOI
Jinping Chen, Chengcheng Du, Bin Tang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160620 - 160620

Published: Feb. 1, 2025

Language: Английский

Citations

1
Mineral nanoparticles and nanocomposite hydrogels with osteoinductive properties for bone regeneration DOI Creative Commons

Cho‐E Choi,

Arghya Paul

Published: March 17, 2025

Mineral nanoparticles and osteoinductive biomaterials are essential in advancing bone regeneration by addressing skeletal conditions injuries that compromise structural integrity functionality. These stimulate the differentiation of precursor cells into osteoblasts, creating biocompatible environments conducive to tissue regeneration. Among most promising innovations, mineral-based nanocomposite hydrogels have emerged as effective strategies for enhancing potential. This review explores diverse types biomaterials, including natural sources, synthetic compounds, hybrid designs incorporate mineralized nanoparticles. Emphasis is placed on polymeric delivery platforms these materials, highlighting their dual role supports bioactive agents promote osteogenesis. Challenges such immune rejection, biodegradability, mechanical stability, short vivo residence time critically discussed, alongside impact clinical translation. By presenting a comprehensive analysis mechanisms, applications, limitations, this identifies opportunities integrating with emerging fields like immunology biomechanics. Ultimately, work aims provide actionable insights advance development novel, clinically relevant solutions improve patient outcomes address growing global need repair

Language: Английский

Citations

1
Cutting-Edge Hydrogel Technologies in Tissue Engineering and Biosensing: An Updated Review DOI Open Access
Nargish Parvin, Vineet Kumar, Sang Woo Joo

et al.

Materials, Journal Year: 2024, Volume and Issue: 17(19), P. 4792 - 4792

Published: Sept. 29, 2024

Hydrogels, known for their unique ability to retain large amounts of water, have emerged as pivotal materials in both tissue engineering and biosensing applications. This review provides an updated comprehensive examination cutting-edge hydrogel technologies multifaceted roles these fields. Initially, the chemical composition intrinsic properties natural synthetic hydrogels are discussed, highlighting biocompatibility biodegradability. The manuscript then probes into innovative scaffold designs fabrication techniques such 3D printing, electrospinning, self-assembly methods, emphasizing applications regenerating bone, cartilage, skin, neural tissues. In realm biosensing, hydrogels’ responsive nature is explored through integration optical, electrochemical, piezoelectric sensors. These sensors instrumental medical diagnostics glucose monitoring, pathogen detection, biomarker identification, well environmental industrial like pollution food quality monitoring. Furthermore, explores cross-disciplinary innovations, including use wearable devices, hybrid systems, potential personalized medicine. By addressing current challenges future directions, this aims underscore transformative impact advancing healthcare practices, thereby providing a vital resource researchers practitioners field.

Language: Английский

Citations

9
Nanotechnology-Assisted mesenchymal stem cells treatment for improved cartilage regeneration: A review of current practices DOI

Hongming Lin,

Chao Zhou, Qingping Li

et al.

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 116895 - 116895

Published: March 1, 2025

Language: Английский

Citations

0
Glutamine Promotes Rotator Cuff Healing by Ameliorating Age-Related Osteoporosis DOI
Haoyuan Wang,

Zhuochang Cai,

Marcus Ying

et al.

Journal of Bone and Joint Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Background: Age-related osteoporosis complicates rotator cuff tear (RCT) treatment, undermining the integrity of surgical anchor fixation during repair (RCR). This study aimed to investigate whether supplementation with glutamine, an intrinsic amino acid crucial in cell metabolism, can enhance healing by ameliorating age-associated osteoporosis. Methods: Forty-eight female Sprague-Dawley rats were divided into 4 groups: (1) young control (sham surgery), (2) aged (3) aged-RCT (RCR fibrin), and (4) aged-RCT-Gln glutamine-enriched fibrin). RCR was performed bilaterally on RCT groups, subsequent application respective fibrin gel at tendon-bone interface. Evaluations included micro-computed tomography (CT) for bone quality, histology immunohistochemistry tissue integrity, biomechanical testing complex strength. Results: Micro-CT revealed worse quality proximal humerus compared rats, confirming spontaneous occurring age. Glutamine improved group group, significantly higher mean volume/total volume fraction (BV/TV) (28.69% ± 3.1% 21.13% 3.9%), trabecular number (Tb.N) (1.88 0.18 1.55 0.21 mm −1 ), thickness (Tb.th) (0.15 0.03 0.12 0.02 mm) lower separation (Tb.sp) (0.19 0.22 mm). Histological immunohistological analysis demonstrated enhanced regeneration a more organized tendon-cartilage-bone interface group. Biomechanical also resilient after glutamine supplementation. Conclusions: Osteoporosis occurred spontaneously effectively mitigated age-related elderly rats. These findings support potential most abundant body, as valuable therapeutic intervention improving outcomes aging population, warranting further investigation clinical settings. Clinical Relevance: may be novel strategy patients

Language: Английский

Citations

0
Revolutionizing Maxillofacial Regeneration Strategies: The Role of Scaffolds in Temporomandibular Joint and jawbone reconstruction DOI Creative Commons
Kai Qian

BIO Web of Conferences, Journal Year: 2025, Volume and Issue: 174, P. 02010 - 02010

Published: Jan. 1, 2025

For the repair of maxillofacial bone defects, traditional surgical methods result in slow healing and often require a second surgery to remove implants. To promote jawbone temporomandibular joint (TMJ) regeneration, scaffolds capable delivering cells growth factors that stimulate cartilage development have become recent focus field tissue engineering. This paper provides comprehensive review scaffold applications oral detailing commonly utilized scaffolds, they load (such as stem macrophages) associated bioactive growth, angiogenesis, osteogenesis. Scaffolds (hydrogels, bioceramics, etc.) can facilitate injuries preservation post-extraction socket sites. Moreover, multi-layer composite hydrogel potential simultaneously regeneration bone, cartilage, articular disc, offering therapeutic approach for disorders. clinicians with scientific evidence guidance selecting appropriate different clinical situations.

Language: Английский

Citations

0
Injectable Hydrogel Technologies for Bone Disease Treatment DOI
Ahmed M. Salama, John G. Hardy,

Abdurohman Mengesha Yessuf

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Injectable hydrogels represent a highly promising approach for localized drug delivery systems (DDSs) in the management of bone-related conditions such as osteoporosis, osteonecrosis, osteoarthritis, osteomyelitis, and osteosarcoma. Their appeal lies their biocompatibility, adjustable mechanical properties, capacity to respond external stimuli, including pH, temperature, light, redox potential, ionic strength, enzymatic activity. These features enable enhanced targeted bioactive agents. This mini-review evaluates synthesis injectable well recent advancements treating range bone disorders, focusing on mechanisms sustained DDSs delivering drugs, nanoparticles, growth factors, cells (e.g., stem cells). Moreover, it highlights clinical studies disease treatment. Additionally, emphasizes potential synergy between hydrogel-based point-of-care technologies, which are anticipated play pivotal role future therapies. have transform treatment by facilitating precise, sustained, minimally invasive therapeutic delivery. Nevertheless, significant challenges, long-term scalability, reproducibility, precise regulation release kinetics, must be addressed unlock fully. Addressing these challenges will not only advance therapy but also open new avenues regenerative medicine personalized healthcare.

Language: Английский

Citations

0
Chitosan-encapsulated lipid-based nanovesicles for therapeutic applications and tissue engineering: A Review DOI Creative Commons

Pegah Vosoughi,

Seyed Morteza Naghib,

Taha Jafari

et al.

Carbohydrate Polymer Technologies and Applications, Journal Year: 2025, Volume and Issue: unknown, P. 100805 - 100805

Published: April 1, 2025

Language: Английский

Citations

0