Russian Journal of Transplantology and Artificial Organs,
Journal Year:
2024,
Volume and Issue:
27(1), P. 90 - 102
Published: Dec. 9, 2024
Bioengineered
pancreatic
constructs
based
on
scaffolds
made
from
decellularized
tissues
and
islets
(PIs)
may
be
used
to
extend
the
functional
activity
of
transplanted
PIs
in
patients
with
type
I
diabetes.
Objective:
investigate
vitro
effect
porcine
liver
scaffold
(DPLS)
viability
insulin-producing
capacity
isolated
human
PIs.
Materials
methods.
The
resulting
DPLS
was
subjected
histological
examination,
DNA
quantification,
cytotoxic
testing.
were
pancreas
fragments
using
collagenase
technique.
Under
standard
conditions,
cultured
three
different
environments:
monoculture
(control
group),
present
(experimental
group
1)
or
(DHPS)
2).
Vital
fluorescent
dyes
evaluate
Basal
glucose-loaded
insulin
concentrations
determined
by
enzyme
immunoassay.
Results.
basic
composition
structure
extracellular
matrix
tissue
samples
preserved
thanks
selected
decellularization
procedure.
had
no
effect,
residual
amount
did
not
exceed
1.0%.
experimental
groups
showed
significant
signs
degradation
fragmentation
during
10-day
incubation
period
compared
control
group.
On
day
10,
1
64%,
that
2
72%,
less
than
20%.
After
first
culturing,
concentration
29.0%
higher
39.1%
10
experiment,
levels
differed
124.8%
150.9%,
respectively,
a
glucose
load,
level
1.7
times
group,
whereas
2.2
higher.
Conclusion.
has
positive
When
creating
bioengineered
construct
PIs,
can
as
component
obtained
sufficient
quantity
an
available
source.
International Journal of Polymeric Materials,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 25
Published: Oct. 24, 2024
A
Comprehensive
Review
delves
into
the
evolution
of
carboxymethyl
cellulose
(CMC)
modifications
and
their
extensive
utilization
in
biomedical
fields.
Various
cross-linking
agents
methods
such
as
physical,
chemical,
photo,
enzymatic
are
explored
for
enhancing
CMC
properties.
This
modified
exhibits
notable
antimicrobial
antifungal
activities,
rendering
it
pivotal
pharmaceutical
formulations.
Moreover,
its
versatility
extends
to
applications
including
drug
delivery,
tissue
engineering,
wound
dressing,
regenerative
medicine,
bioimaging,
biosensing,
diagnosis,
Vaccine
immunotherapy
other
therapeutic
purposes.
review
provides
a
thorough
insight
multifaceted
roles
contemporary
sciences.
One Health Journal,
Journal Year:
2025,
Volume and Issue:
3(3), P. 48 - 55
Published: April 29, 2025
The
study
investigates
the
production
and
characterization
of
alginate
films
for
immobilization
delivery
probiotic
bacterium
Lactobacillus
bulgaricus
1Z
03501.
Alginate
were
synthesized
using
ionotropic
gelation
with
calcium
chloride,
four
different
protocols
evaluated.
characterized
in
terms
their
physical
properties,
dissolution
behavior,
viability
immobilized
bacteria.
results
demonstrate
that
can
be
successfully
produced
a
spraying
method,
process
does
not
negatively
affect
L.
developed
show
potential
application
as
wound
dressings
delivery.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(11), P. 1388 - 1388
Published: Oct. 28, 2024
:
Hydrogels
produced
using
the
freeze-thaw
method
have
demonstrated
significant
potential
for
wound
management
applications.
However,
their
production
requires
precise
control
over
critical
factors
including
freezing
temperature
and
choice
of
matrix-forming
excipients,
which
no
consensus
on
optimal
conditions
currently
exists.
This
study
aimed
to
address
this
gap
by
evaluating
effects
above-mentioned
variables
cryogel
performance.
IGI Global eBooks,
Journal Year:
2025,
Volume and Issue:
unknown, P. 119 - 146
Published: March 14, 2025
Aerogels
have
garnered
significant
attention
in
biomedical
applications
due
to
their
unique
properties.
This
review
explores
three
key
areas:
biosensing,
imaging,
and
bone
regeneration.
In
aerogels
serve
as
excellent
platforms
for
immobilizing
biomolecules,
enabling
sensitive
detection
of
analytes
through
various
mechanisms
such
fluorescence
or
surface
plasmon
resonance.
low
density
high
area
make
promising
candidates
contrast
agents
drug
delivery
vehicles
magnetic
resonance
imaging
computed
tomography.
Furthermore,
biocompatibility
tunable
porosity
render
suitable
scaffolds
regeneration,
promoting
cell
adhesion,
proliferation,
mineralization.
abstract
underscores
the
multifaceted
roles
play
addressing
diverse
challenges,
paving
way
future
breakthroughs
healthcare.
International Journal of Polymeric Materials,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 19
Published: Aug. 5, 2024
Skin
tissue
engineering
has
emerged
as
a
promising
field
for
developing
wound
dressings
and
skin
substitutes.
Recently,
cryogel
based
scaffolds
have
gained
significant
attention
due
to
their
biocompatibility,
tunable
properties
porous
structure
resembling
the
native
extracellular
matrix.
Polysaccharides
like
sodium
alginate,
chitosan,
dextran,
agarose
are
widely
explored
fabricating
cryogels
inherent
biocompatibility
bioactivity.
The
review
begins
by
highlighting
significance
of
in
treating
different
dermatological
conditions
injuries.
It
then
explores
fundamental
polysaccharide
scaffolds,
focusing
on
biodegradability,
fabrication
methods
biomedical
applications
polysaccharides
engineering.
In
addition,
it
potential
integrating
3D
4D
printing
technologies
enhance
functionality
these
leading
widespread
adoption
clinical
settings
healing
personalized
medicine
offering
tailored
solutions
repair
regeneration.
Overall,
this
emphasizes
immense
advancing
engineering,
novel
healing,
medicine.
