The “sweet” path to cancer: focus on cellular glucose metabolism

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: May 25, 2023

The hypoxia-inducible factor-1α (HIF-1α), a key player in the adaptive regulation of energy metabolism, and M2 isoform glycolytic enzyme pyruvate kinase (PKM2), critical regulator glucose consumption, are main drivers metabolic rewiring cancer cells. use glycolysis rather than oxidative phosphorylation, even presence oxygen (i.e., Warburg effect or aerobic glycolysis), is major hallmark cancer. Aerobic also important for immune system, which involved both disorders development tumorigenesis. More recently, changes resembling have been described diabetes mellitus (DM). Scientists from different disciplines looking ways to interfere with these cellular rearrangements reverse pathological processes underlying their disease interest. As overtaking cardiovascular as leading cause excess death DM, biological links between DM incompletely understood, metabolism may be promising field explore search connections cardiometabolic diseases. In this mini-review, we present state-of-the-art on role effect, HIF-1α, PKM2 cancer, inflammation, encourage multidisciplinary research advance fundamental understanding biology pathways implicated link

Language: Английский

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Repurposing metabolic regulators: antidiabetic drugs as anticancer agents

Molecular Biomedicine, Journal Year: 2024, Volume and Issue: 5(1)

Published: Sept. 28, 2024

Abstract Drug repurposing in cancer taps into the capabilities of existing drugs, initially designed for other ailments, as potential treatments. It offers several advantages over traditional drug discovery, including reduced costs, development timelines, and a lower risk adverse effects. However, not all classes align seamlessly with patient's condition or long-term usage. Hence, chronically used drugs presents more attractive option. On hand, metabolic reprogramming being an important hallmark paves regulators possible therapeutics. This review emphasizes importance current insights antidiabetic metformin, sulfonylureas, sodium-glucose cotransporter 2 (SGLT2) inhibitors, dipeptidyl peptidase 4 (DPP-4) glucagon-like peptide-1 receptor agonists (GLP-1RAs), thiazolidinediones (TZD), α-glucosidase against various types cancers. Antidiabetic regulating pathways have gained considerable attention research. The literature reveals complex relationship between risk. Among metformin may possess anti-cancer properties, potentially reducing cell proliferation, inducing apoptosis, enhancing sensitivity to chemotherapy. revealed heterogeneous responses. Sulfonylureas TZDs demonstrated consistent activity, while SGLT2 inhibitors DPP-4 shown some benefits. GLP-1RAs raised concerns due associations increased certain highlights that further research is warranted elucidate mechanisms underlying effects these establish their efficacy safety clinical settings.

Language: Английский

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Mangiferin Protects Mesenchymal Stem Cells Against DNA Damage and Cellular Aging via SIRT1 Activation

Mechanisms of Ageing and Development, Journal Year: 2025, Volume and Issue: unknown, P. 112038 - 112038

Published: Jan. 1, 2025

Language: Английский

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Hyperglycemia-driven signaling bridges between diabetes and cancer

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 229, P. 116450 - 116450

Published: July 25, 2024

Language: Английский

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Vitamin B6 and diabetes and its role in counteracting advanced glycation end products

Vitamins and hormones, Journal Year: 2024, Volume and Issue: unknown, P. 401 - 438

Published: Jan. 1, 2024

Language: Английский

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Diabetes and Cancer: A Twisted Bond

Oncology Reviews, Journal Year: 2024, Volume and Issue: 18

Published: May 21, 2024

This paper presents an overview of the interconnection between various factors related to both cancer and type 2 diabetes mellitus (T2DM). Hyperglycemia, hyperinsulinemia, chronic inflammation, obesity are involved in development progression diseases but, strong evidence for a direct causal relationship cancer, is lacking. Several studies described hyperglycemia at cellular, tissular organismic levels but same time recent Mendelian randomization proved significant only breast cancer. On other hand, association hyperinsulinemia several types appears be robust as demonstrated by randomized studies. Metabolic alterations, including Warburg effect excessive glucose consumption tumors, discussed, highlighting potential impact dietary restrictions, such fasting low-carb diets, on tumor growth inflammation. Recent data indicates that circulating branched-chain amino acids levels, may represent novel biomarkers contribute better control early pancreatic detection. Understanding underlying mechanisms shared risk T2DM can provide valuable insights prevention, detection, management strategies.

Language: Английский

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High-glucose impact on UVB responses in human epidermal keratinocytes: Insights on diabetic skin's resistance to photocarcinogenesis

Life Sciences, Journal Year: 2024, Volume and Issue: 357, P. 123083 - 123083

Published: Sept. 27, 2024

Language: Английский

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Special Issue “DNA Replication/Repair, and the DNA Damage Response in Human Disease”

Genes, Journal Year: 2023, Volume and Issue: 14(4), P. 893 - 893

Published: April 11, 2023

Mutations of numerous genes involved in DNA replication, repair, and damage response (DDR) pathways lead to a variety human diseases, including aging cancer [...]

Language: Английский

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