Positive Selection in Zinc Finger Protein Reveals Genetic Signatures of Adaptive Evolution in Undifferentiated Stem Cells during Evolution in Mammals DOI Creative Commons

Mahboob Ali,

Palwasha Khan,

Mahreen Mahmood

et al.

Journal of Zoological Systematics & Evolutionary Research, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 15

Published: May 29, 2023

Positive selection refers to the process by which certain genetic variations are more likely be passed on future generations because they confer some advantage in terms of survival or reproduction. Zinc finger proteins a type transcription factor that plays role regulating gene expression, particularly undifferentiated stem cells. Suppose it has been found zinc show signatures positive mammals. In case, suggests these may have played adaptive evolution This could mean specific changes gave an organisms possessed them, helping them survive and reproduce effectively. These allowed adapt changing environments develop new abilities, such as increased resistance disease faster growth. Undifferentiated cells underwent during mammals can identified genetically outcomes proteins. Because pressures like environmental shifts introduction novel pathogens, is plausible experienced fast evolution. The emergence activities higher expression levels result this quick given creatures edge. Another possible outcome allow for diversity plasticity efficient adaptation characteristics existing organisms. Overall, results provide insight into how occurred contributed development adaptations environments.

Language: Английский

Bioengineering in Solid-State Fermentation for next sustainable food bioprocessing DOI Creative Commons
Muyideen Olaitan Bamidele, Micheal Bola Bamikale, Eliseo Cárdenas-Hernández

et al.

Next Sustainability, Journal Year: 2025, Volume and Issue: 6, P. 100105 - 100105

Published: Jan. 1, 2025

Language: Английский

Citations

6
Phylogenetic analysis and detection of positive selection in the SIRT gene family across vertebrates DOI Creative Commons

Qiuxi Zhou,

Xiongtao Yang,

Da Li

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 5, 2025

SIRT6, a member of the sirtuin protein family, is recognized as tumor suppressor. This study investigates evolutionary history SIRT gene family and examines selective pressures shaping their functional divergence. Insights into evolution these genes may enhance our understanding roles in disease pathology. Seventy-three amino acid sequences full-length mRNA from 22 vertebrate species one invertebrate were retrieved public databases. Phylogenetic relationships among seven members reconstructed using Bayesian inference. Codon-based models applied to detect site-specific positive selection, likelihood ratio tests (LRTs) used compare model fits. Positively selected sites identified empirical Bayes (BEB) methods. analysis revealed that vertebrates originated duplication events. Asymmetric rates natural selection primary drivers Eleven positively (23I, 310 S, 311I, 313 A, 316 K, 320 C, 321 322Q, 323 H, 327E, 328P) with high confidence (posterior probability ≥ 99%), suggesting critical The characterized by selection. phylogenetic tree elucidates members, SIRT6 emerging key node. this represent mutation hotspots, providing potential targets for future cancer therapy research.

Language: Английский

Citations

0
Dynamic Outlier Slicing Allows Broader Exploration of Adaptive Divergence: A Comparison of Individual Genome and Pool‐Seq Data Linked to Humic Adaptation in Perch DOI Creative Commons
María E. López, Mikhail Ozerov, Lilian Pukk

et al.

Molecular Ecology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

ABSTRACT How genetic variation contributes to adaptation at different environments is a central focus in evolutionary biology. However, most free‐living species still lack comprehensive understanding of the primary molecular mechanisms adaptation. Here, we characterised targets selection associated with drastically aquatic environments—humic and clear water—in common freshwater fish, Eurasian perch ( Perca fluviatilis ). By using whole‐genome sequencing (WGS) on large population dataset n = 42 populations) analysing 873,788 SNPs, our aim was uncover novel confirm known footprints selection. We compared individual pooled WGS, developed approach, termed dynamic outlier slicing, assess how choice outlier‐calling stringency influences functional Gene Ontology (GO) enrichment. integrating genome‐environment association (GEA) analysis allele frequency‐based approaches, estimated composite signals (CSS) identified 2679 SNPs distributed across 324 genomic regions, involving 468 genes. Dynamic slicing robust enrichment five annotation categories (upstream, downstream, synonymous, 5′UTR 3′UTR) highlighting crucial role regulatory elements adaptive evolution. Furthermore, GO analyses revealed strong functions gated channel activity, transmembrane transporter activity ion emphasising importance osmoregulation balance maintenance. Our findings demonstrate that despite substantial random drift divergence, WGS high number pools enabled identification both humic water environments, providing evidence widespread anticipate method will enable more thorough exploration divergence diverse range species.

Language: Английский

Citations

0
Characterization of five Neisseria homoserine dehydrogenases with diverse coenzyme specificities reveals adaptive evolution of the hom6 genes DOI
Wanggang Tang,

Shuping Fei,

Jinmin Zhao

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142603 - 142603

Published: March 1, 2025

Language: Английский

Citations

0
Adaptive Evolution in Wild Animals: Key Traits and Evolutionary Mechanisms DOI Open Access
Xian Li, Jia Chen

International Journal of Molecular Evolution and Biodiversity, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Adaptive evolution plays a crucial role in the survival and diversification of wild animals. This study examines significance, key traits, mechanisms adaptive evolution, providing insights into ecological, evolutionary, conservation implications. The discusses various traits such as morphological adaptations (e.g., beak shape birds), behavioral migratory patterns), physiological thermoregulation), genetic allele frequency changes), reproductive mating strategies). Evolutionary including natural selection, drift, gene flow, mutation, sexual selection are explored with relevant examples. Case studies radiation Darwin's finches, industrial melanism peppered moths, predator-prey dynamics illustrate these concepts. Advances genomic approaches, environmental influences, epigenetics highlight modern understanding evolution. underscores importance integrating multidisciplinary approaches to emphasizing its relevance for strategies. By addressing knowledge gaps encouraging ongoing research, we aim enhance our comprehension biodiversity species rapidly changing world.

Language: Английский

Citations

0
Demographic History and Adaptive Evolution of Indo‐Pacific Bottlenose Dolphins (Tursiops aduncus) in Western Australia DOI Creative Commons
Svenja M. Marfurt, D. Chabanne, S. Wittwer

et al.

Molecular Ecology, Journal Year: 2024, Volume and Issue: 33(22)

Published: Oct. 22, 2024

ABSTRACT Demographic processes can substantially affect a species' response to changing ecological conditions, necessitating the combined consideration of genetic responses environmental variables and neutral variation. Using seascape genomics approach with population demographic modelling, we explored interplay factors that shaped current structure in Indo‐Pacific bottlenose dolphins ( Tursiops aduncus ) along Western Australian coastline. We large‐scale data gathered via remote sensing RADseq genomic from 133 individuals at 19 sampling sites. outlier detection analyses, identified three distinct clusters, coinciding tropical, subtropical temperate provincial bioregions. In contrast previous studies, our models indicated populations occupying paleo‐shoreline split into two demographically independent lineages before last glacial maximum (LGM). A subsequent after LGM 12—15 kya gave rise Shark Bay population, thereby creating currently observed clusters. Although multi‐locus heterozygosity declined north south, southernmost cluster inhabiting waters had higher potentially adaptive loci compared tropical waters. These findings suggest ongoing adaptation cold‐temperate cluster, possibly linked selective pressures between different Our study demonstrated marine realm, without apparent physical boundaries, only fully elucidate intricate interactions shaping evolutionary trajectory mammals.

Language: Английский

Citations

0
Characterization and organization of telomeric-linked helicase (tlh) gene families in Fusarium oxysporum DOI

Sahar Salimi,

Mona Abdi,

Mostafa Rahnama

et al.

Current Genetics, Journal Year: 2024, Volume and Issue: 70(1)

Published: Nov. 12, 2024

Language: Английский

Citations

0
Genetic Adaptations Inradioactive Environments: Lessons from Organisms Near Nuclear Waste Sites DOI

G. Jithu Priya,

S. Sibi Sidharth,

Rohit Rahul

et al.

Environmental science and engineering, Journal Year: 2024, Volume and Issue: unknown, P. 307 - 324

Published: Dec. 10, 2024

Language: Английский

Citations

0
Positive Selection in Zinc Finger Protein Reveals Genetic Signatures of Adaptive Evolution in Undifferentiated Stem Cells during Evolution in Mammals DOI Creative Commons

Mahboob Ali,

Palwasha Khan,

Mahreen Mahmood

et al.

Journal of Zoological Systematics & Evolutionary Research, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 15

Published: May 29, 2023

Positive selection refers to the process by which certain genetic variations are more likely be passed on future generations because they confer some advantage in terms of survival or reproduction. Zinc finger proteins a type transcription factor that plays role regulating gene expression, particularly undifferentiated stem cells. Suppose it has been found zinc show signatures positive mammals. In case, suggests these may have played adaptive evolution This could mean specific changes gave an organisms possessed them, helping them survive and reproduce effectively. These allowed adapt changing environments develop new abilities, such as increased resistance disease faster growth. Undifferentiated cells underwent during mammals can identified genetically outcomes proteins. Because pressures like environmental shifts introduction novel pathogens, is plausible experienced fast evolution. The emergence activities higher expression levels result this quick given creatures edge. Another possible outcome allow for diversity plasticity efficient adaptation characteristics existing organisms. Overall, results provide insight into how occurred contributed development adaptations environments.

Language: Английский

Citations

0