Journal of Biochemical and Molecular Toxicology,
Journal Year:
2024,
Volume and Issue:
38(12)
Published: Dec. 1, 2024
Polyethylene
terephthalate
nanoplastics
(PET-NPs)
are
one
of
the
most
frequently
distributed
in
daily
life.
Betaine
is
thought
to
be
a
promising
hepatoprotective
agent.
The
current
investigation
focused
on
whether
orally
administered
PET-NPs
caused
hepatotoxicity
and
ameliorative
effect
betaine.
Forty
adult
male
Swiss
albino
mice
were
randomly
split
into
four
groups:
group
I
control,
II
betaine
(1000
mg/kg
I/P),
III
(200
orally),
IV
plus
at
doses
similar
II&
respectively.
After
30
days,
blood
sample
collected
then
animals
euthanized
liver
specimens
dissected
out
for
biochemical
histopathological
examination.
induced
significant
elevation
alanine
aminotransferase
(ALT),
aspartate
(AST),
malondialdehyde
(MDA),
as
well
an
increase
inflammatory
genes
proto-oncogene
(c-FOS)
cyclooxygenase
2
(COX2)
(p
≤
0.05),
with
substantial
decrease
glutathione
(GSH)
0.05).
Furthermore,
level
analysis
alterations
hepatic
tissue
architecture
vascular
dilatation
congestion
hepatocytes
degeneration,
bile
duct
epithelial
hyperplasia
cell
infiltrations
While
immunohistochemistry,
trigger
positive
tumor
necrosis
factor-alpha
(TNF-α)
nuclear
factor-kappa
B
(NF-ҠB)
expression
comparison
control.
Meanwhile,
treatment
reduced
deleterious
effects
PET-NPs.
To
summarize,
may
cause
mice,
belief
that
could
mitigate
detrimental
impact.
