The Influence of Hyperlipidemia on the Results of Mammography in Postmenopausal Women DOI Open Access
Fahri Burçin Fıratlıgil, Belgin Savran Üçok, Erkan Sağlam

et al.

Türk Kadın Sağlığı ve Neonatoloji Dergisi, Journal Year: 2024, Volume and Issue: 6(4), P. 124 - 130

Published: Nov. 6, 2024

Aim: To determine whether hyperlipidemia causes specific or nonspecific changes that can be detected by mammography in postmenopausal women. Materials and Method: This study was conducted retrospectively designed as a case-control the gynecology clinics of Etlik Zubeyde Hanim Women’s Health Education Training Hospital between January 2017 2020. Healthy women with total cholesterol (TC) level 200 mg/dL above mg/dL, who were examined our outpatient whose mammographic controls performed hospital, included group (Group I). TC below followed up at same clinic control II). We analyzed TC, low-density lipoprotein cholesterol, very-low-density high-density triglycerides findings. Results: There no significant differences groups terms age body mass index. smoking status family history breast cancer. The BAC BI-RADS scoring category scores differed significantly (p=0.006 p=0.042, respectively). Conclusion: Postmenopausal have findings lead to Considering may also other morbidity mortality, such hypertension, diabetes mellitus cardiovascular disease, it is necessary treat lifestyle / medications. As this retrospective limited number patients, clear future randomized controlled trials could provide more reliable data on topic.

Language: Английский

Clinical and mechanistic insights into biomedical application of Se-enriched probiotics and biogenic selenium nanoparticles DOI

Farshid Ataollahi,

Bagher Amirheidari,

Zohreh Amirheidari

et al.

Biotechnology Letters, Journal Year: 2025, Volume and Issue: 47(1)

Published: Jan. 18, 2025

Language: Английский

Citations

1
Magnetic Particle Imaging Reveals that Iron-Labeled Extracellular Vesicles Accumulate in Brains of Mice with Metastases DOI Creative Commons

Victoria Toomajian,

Anthony Tundo,

Evran Ural

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(24), P. 30860 - 30873

Published: June 11, 2024

The incidence of breast cancer remains high worldwide and is associated with a significant risk metastasis to the brain that can be fatal; this due, in part, inability therapeutics cross blood–brain barrier (BBB). Extracellular vesicles (EVs) have been found BBB further used deliver drugs tumors. EVs from different cell types appear patterns accumulation retention as well efficiency bioactive cargo delivery recipient cells body. Engineering tools treat metastases, therefore, will require an understanding timing EV their localization relative metastatic sites. Magnetic particle imaging (MPI) sensitive quantitative method directly detects superparamagnetic iron. Here, we demonstrate MPI novel tool characterize biodistribution disease after labeling iron oxide (SPIO) nanoparticles. Iron-labeled (FeEVs) were collected iron-labeled parental primary 4T1 tumor brain-seeking 4T1BR5 cells, followed by injection into mice orthotopic tumors or metastases. quantification revealed FeEVs retained for longer mammary carcinomas compared SPIOs. signal due could only detected brains bearing metastases FeEVs, but not SPIOs, when did These findings indicate potential use therapeutic

Language: Английский

Citations

5
Editorial: Advances of brain metastasis in breast cancer DOI Creative Commons

Weiwei Lv,

Adam Brufsky, Takahiro Ochiya

et al.

Frontiers in Human Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: Jan. 22, 2025

Breast cancer is the most frequently diagnosed malignancy among women worldwide and a leading cause of cancer-related deaths. Brain metastasis, severe complication advanced breast cancer, significantly worsens prognosis due to challenges posed by blood-brain barrier (BBB) aggressive nature metastatic cells (1). The development brain metastases from involves multiple steps, including detachment primary tumor, invasion into bloodstream, colonization (2). BBB, which protects harmful substances, also limits effectiveness many chemotherapeutic agents. Recent studies have identified several molecular pathways genetic mutations that facilitate penetration through BBB their subsequent growth in brain. Key players include HER2 (human epidermal factor receptor 2) BRCA (breast gene) mutations, are associated with more disease higher likelihood metastasis (3,4). This research topic aims highlight recent advances treatments discovery new targets or agents, novel methods pre-clinical clinical trials, as well deeper insights focusing on known agents treatments.Understanding basis central nervous system crucial for developing effective treatments. Lipocalin-2 (LCN2), an iron transport protein, implicated progression (BCBM) (5). In tumors, LCN2 promotes cell proliferation, angiogenesis, interacting matrix metalloproteinase-9 facilitating epithelialmesenchymal transition. microenvironment, disrupts bloodbrain aids tumor seeding modulating cellular behavior. Zhang et al. reviewed LCN2's role BCBM its potential therapeutic target biomarker, suggesting targeting could improve outcomes patients.Extracellular vesicles (EVs), small lipid bilayer containing biomolecules, play this process delivering bioactive molecules recipient regulating signal transduction protein expression. EVs were confirmed key regulation immune microenvironment expected make immunotherapy diagnosis. ( 6) Yusuke Yoshioka mechanisms promote discusses EV-associated early diagnostic markers.Immune checkpoint inhibitors (ICIs) represent promising option patients BCBM, particularly those TNBC otherwise very limited nonchemotherapy systemic therapy options (7). However, it remains essential investigate factors influencing efficacy ICIs treatment. A study found high mutation burden (TMB) lesions suggests benefits (8). Additionally, TREML2 BTLA poor prognostic factors, activated microglia may serve treatment targets. Mustafa investigated increasing incidence patients, lung cancers, despite advancements targeted therapies. It explored differences between these cancers identify specific druggable Analyzing 44 tissue samples, significant upregulation genes tumors compared metastases. findings association upregulated metabolic stress pathways, response regulation, growth, proliferation. Notably, expression checkpoints VTCN1 VISTA, IDO1, NT5E, HDAC3 adenocarcinoma validated. suggested be targets.Multiple drugs been validated trials both safe DESTINY-Breast12 (DB12) evaluated safety trastuzumab deruxtecan (T-DXd) HER2-positive median progression-free survival (PFS) was 17.3 months, 12-month PFS rate 61.6%. intracranial objective (CNS ORR) 71.7%, indicating strong treating (9). When combined capecitabine, tucatinib has improved extracranial overall after previous trastuzumab-deruxtecan (10). Ping Sun anti-angiogenic agent anlotinib triple-negative (TNBC) who had failed prior 29 October 2019 April 2024, PFS) 7.2 (OS) 10.2 months. (iORR) 31.0%, control (iDCR) 86.2%. Five experienced grade 3-4 adverse events, bone marrow suppression being common. Most events manageable, no treatment-related deaths occurred. offered metastases.In conclusion, articles compiled Research Topic offer thorough examination understanding metastasis. persist. Ongoing therapies enhancing quality life suffering devastating condition.

Language: Английский

Citations

0
Differential Diagnosis of a Well-Enhancing Intracisternal Lesion in a Breast Cancer Patient DOI

Haa‐Na Song,

Ho‐Shin Gwak

Brain Tumor Research and Treatment, Journal Year: 2025, Volume and Issue: 13(1), P. 34 - 34

Published: Jan. 1, 2025

This case introduces the differential diagnosis of a well-enhancing lesion in prepontine cistern 55-year-old female patient who was diagnosed with recurrent metastatic breast cancer. The cancer 11 years ago and underwent mastectomy subsequent adjuvant therapy. Tamoxifen had been given for 5 years, treatment completed. Five after, she found lung nodule on her routine chest X-ray examination. Based past medical history, systemic work-up done it revealed multiple lesions T10 vertebra, lungs, mediastinal lymph nodes. Trans-bronchial needle aspiration performed biopsy Brain MRI taken as complaining headache showed well-defined, ovoid enhancing 0.9-cm right cistern. Neuro-oncology tumor board evaluated more likely to be an asymptomatic neurogenic rather than metastasis based radiological features including brainstem surfaced location, slightly high signal intensity T2-weighted image no diffusion restriction. To rule out leptomeningeal metastasis, serial cerebrospinal fluid cytology examination (×3) negative malignant cells. Follow-up brain MRIs 2 9 months significant changes pre-pontine lesion.

Language: Английский

Citations

0
Sequencing of high-frequency mutated genes in breast cancer (BRCA) and associated-functions analysis DOI
Xue‐Lian Li, Mei Yang, Liyuan Yang

et al.

International Journal of Clinical and Experimental Pathology, Journal Year: 2025, Volume and Issue: 18(2), P. 46 - 62

Published: Jan. 1, 2025

Mutations or aberrant expression of genes in an organism tend not to be completely random and this cumulative effect predisposes the development malignant tumours. This study aims reveal possible high frequency mutated genes, then investigate their role development, prognosis, signalling pathway function drug resistance breast cancer. The cancer (BRCA) clinical samples were identified detected by high-throughput sequencing. High-frequency mutant counted. Gene profiles relationship with prognosis analysed throughout TCGA database. qRT-PCR was used analyse mRNA levels six high-frequency BRCA tissues cell lines. IHC protein tissues. linear interaction, single-cell layer clustering status influence immune infiltration degree among these bioinformatics analysis. STITCH cMAP datasets for gene interaction networks, association enrichment drug-transcriptome analyses. effects trastuzumab on proliferative capacity cells, as well determined CCK8 assay. that statistically found have mutations recruited present sequencing analysis included TP53, PIK3CA, NF1, TBX3, BRCA1 BRCA2. correlation further demonstrated using database: trend similar TCGA. showed BRCA2 higher tumor than normal samples, opposite a observed expressions displayed same IHC. Other results include 1) single resulted significant few overlapping regions; 2) different degrees infiltration; 3) between each other; 4) network had partially molecules; 5) PI3K key BRCA. Finally, proliferation ability confirmed optimal concentration its genes.

Language: Английский

Citations

0
Molecular mechanisms and signaling pathways related to brain metastasis in breast cancer DOI Creative Commons

Zixin Liang,

Yanan Mo, Yujiao Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 27, 2025

Brain metastasis in breast cancer (BCBM) significantly threatens the survival and quality of life patients, particularly those with triple-negative (TNBC) HER2-positive subtypes. It involves complex molecular mechanisms diverse signaling pathways. This review highlights recent research on pathways BCBM. The process BCBM includes several key steps: local infiltration cells into bloodstream subsequent spread to brain. They must then overcome blood-brain barrier (BBB) establish grow Multiple pathways, including PI3K/AKT, STAT3, NF-κB, Notch, Wnt are involved this process. Overall, is a disease regulated by multiple To improve patient life, it crucial deepen explore new treatment targets strategies. will enhance our understanding lead more effective treatments.

Language: Английский

Citations

0
Biological mechanisms and immunotherapy of brain metastases in non-small cell lung cancer DOI
Shih Sheng Jiang, Fengzhu Guo, Lin Li

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189320 - 189320

Published: April 1, 2025

Language: Английский

Citations

0
In vitro study on anti-proliferative and anti-cancer activity of picrosides in triple-negative breast cancer DOI
Deepika Soni, Divya Wahi, Saurabh Verma

et al.

Medical Oncology, Journal Year: 2024, Volume and Issue: 41(6)

Published: May 8, 2024

Language: Английский

Citations

3
Clinico–pathologic factors and survival of patients with breast cancer diagnosed with de novo brain metastasis: a national cancer database analysis DOI Creative Commons
Ali Hijazi, Mohamed Mohanna, Saad Sabbagh

et al.

Breast Cancer Research and Treatment, Journal Year: 2024, Volume and Issue: 206(3), P. 527 - 541

Published: April 29, 2024

Abstract Purpose Patients with Breast Cancer (BC) Brain Metastasis (BCBM) have poor survival outcomes. We aimed to explore the clinico–pathologic and therapeutic factors predicting in patients de novo BCBM using National Database (NCDB). methods The NCDB was queried for BC between 2010 2020. Survival analysis Kaplan–Meier curves log rank tests were used find median overall (OS) months (95% CI) across different variables. A multivariate cox regression model computed identify significant predictors of survival. Results Out n = 2,610,598 patients, 9005 (0.34%) had BCBM. trend decreasing OS observed increasing age, Charlson–Deyo score (CDS), number extracranial metastatic sites. highest Triple Positive lowest Negative subgroup. Based on treatment regimen, combination systemic therapy local achieved OS. positive subgroup targeted demonstrating a benefit when added therapy. showed that race, ethnicity, insurance, income, facility type, CDS, subtype, location sites, combinations received significantly associated risk death. Receiving only BM without more than doubled death compared combining it Conclusions This suggests disease is major factor influencing Moreover, anti–HER2 increased explaining noted

Language: Английский

Citations

2
Lipocalin-2 promotes breast cancer brain metastasis by enhancing tumor invasion and modulating brain microenvironment DOI Creative Commons
Yang Zhao,

Xiaogen Tang,

Tingting Lei

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Aug. 12, 2024

Breast cancer is the leading diagnosed in women globally, with brain metastasis emerging as a major cause of death, particularly human epidermal growth factor receptor 2 positive and triple-negative breast subtypes. Comprehensive understanding molecular foundations central nervous system metastases imperative for evolution efficacious treatment strategies. Lipocalin-2 (LCN2), secreted iron transport protein multiple functions, has been linked to progression (BCBM). In primary tumors, LCN2 promotes proliferation angiogenesis cells, triggers epithelial-mesenchymal transition, interacts matrix metalloproteinase-9, thereby facilitating reorganization extracellular enhancing cell invasion migration. microenvironment, undermines blood-brain barrier facilitates tumor seeding by modulating behavior key cellular components. summary, this review meticulously examines fuel role BCBM cascade, investigates potential mechanisms involved. It highlights both therapeutic target biomarker, indicating that interventions targeting may offer improved outcomes patients afflicted BCBM.

Language: Английский

Citations

2