Overcoming challenges in glioblastoma treatment: targeting infiltrating cancer cells and harnessing the tumor microenvironment

Frontiers in Cellular Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Dec. 21, 2023

Glioblastoma (GB) is a highly malignant primary brain tumor with limited treatment options and poor prognosis. Despite current approaches, including surgical resection, radiation therapy, chemotherapy temozolomide (TMZ), GB remains mostly incurable due to its invasive growth pattern, drug penetration beyond the blood-brain barrier (BBB), resistance conventional therapies. One of main challenges in effectively eliminating infiltrating cancer cells that remain parenchyma after resection. We’ve reviewed most recent surveyed potential strategies aimed at enhancing local outcomes.

Language: Английский

---

Predictors of early recurrence in meningioma

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 26, 2024

Purpose – Although meningiomas have mostly a favourable prognosis, some early recurrences or the need for new treatment, irrespective of histological grade. In this study, we aimed to characterize clinical, radiological, and molecular markers in cohort patients with recurrent meningiomas. Methods We conducted retrospective, non-interventional study World Health Organization (WHO) grade 1 2 who underwent surgical resection at Centro Hospitalar Universitário de São João between 2010 2021, had tumour recurrence needed retreatment subsequent 5 years. analysed demographic, histological, treatment-associated parameters, features (TERT promotor mutations CDKN2A/B deletion), progression/survival data. An analysis was determine which variables were associated shorter time-to-progression, aiming identify predictors greater impact on rapid recurrence. Results evaluated 64 patients. The median time progression-free survival (PFS) 26 months. Shorter PFS WHO (11 vs 27 months, p = 0.010), mitotic index ≥8 (7 <0.001), T1-weighted image signal (T1w) hyperintensity (15 0.025). None cases showed deletion, while TERT promoter detected four Conclusion meningiomas, 2, ≥8, T1w significantly PFS, biomarkers usually deletion) only

Language: Английский

---

Telomere Maintenance Mechanisms in Cancer

Interdisciplinary cancer research, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

---

TERTmonitor Efficacy and Performance in Detecting Mutations by Droplet Digital PCR

Genes, Journal Year: 2024, Volume and Issue: 15(11), P. 1424 - 1424

Published: Oct. 31, 2024

The screening of TERT promoter (

Language: Английский

---