Comprehensive Mendelian randomization analysis of low-density lipoprotein cholesterol and multiple cancers
Abstract
Purpose:
The
aim
of
this
study
was
to
investigate
the
causal
relationship
between
low-density
lipoprotein
cholesterol
(LDL-C)
and
five
cancers
(breast,
cervical,
thyroid,
prostate
colorectal)
using
Mendelian
Randomization
(MR)
method,
with
a
view
revealing
potential
role
LDL-C
in
development
these
cancers.
Methods: We
used
gene
variant
data
disease
from
Genome-Wide
Association
Study
(GWAS)
database
assess
each
cancer
by
randomisation
analysis
methods
such
as
inverse
variance
weighting
MR-Egger.
Specifically,
we
selected
Proprotein
convertase
subtilisin/kexin
type
9(PCSK9)
3-hydroxy-3-methylglutaryl-CoA
reductase(HMGCR),
genes
associated
levels,
instrumental
variables,
extracted
corresponding
single
nucleotide
polymorphism
(SNP)
analysed
associations
SNPs
cancers.In
addition,
sensitivity
analyses
heterogeneity
tests
were
performed
ensure
reliability
results
Results:
showed
that
when
HMGCR
gene,LDL-C
significantly
positively
breast
(OR:1.200,
95%
CI:1.082-1.329,
p=0.001),
(OR:1.198,
CI:1.050-1.366,
p=0.007),
thyroid
(OR:8.291,
CI:3.189-
21.555,
p=0.00001)
correlated,
whereas
they
negatively
correlated
colorectal
(OR:0.641,
CI:0.442-0.928,
p=0.019);
for
cervical
not
significant
(p=0.050).
When
PCSK9
gene,
levels
(OR:1.107,
95%:CI
1.031-1.187,
p=0.005)
(OR:1.219,
1.101-1.349,
p=0.0001)
cancers,
but
(p=0.294),
(p=0.759)
(
p=0.572).
Conclusion:
Analyses
both
have
shown
may
be
risk
factor
cancer,
while
also
suggested
increase
decrease
cancer.
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 22, 2024
Language: Английский