Recent Treatment Strategies and Molecular Pathways in Resistance Mechanisms of Antiangiogenic Therapies in Glioblastoma

Cancers, Journal Year: 2024, Volume and Issue: 16(17), P. 2975 - 2975

Published: Aug. 27, 2024

Malignant gliomas present great difficulties in treatment, with little change over the past 30 years median survival time of 15 months. Current treatment options include surgery, radiotherapy (RT), and chemotherapy. New therapies aimed at suppressing formation new vasculature (antiangiogenic treatments) or destroying formed tumor (vascular disrupting agents) show promise. This study summarizes existing knowledge regarding processes by which glioblastoma (GBM) tumors acquire resistance to antiangiogenic treatments. The discussion encompasses activation redundant proangiogenic pathways, heightened cell invasion metastasis, induced hypoxia, creation vascular mimicry channels, regulation immune microenvironment. Subsequently, we explore potential strategies overcome this resistance, such as combining other methods, personalizing treatments for each patient, focusing on therapeutic targets, incorporating immunotherapy, utilizing drug delivery systems based nanoparticles. Additionally, would like discuss limitations methods future directions enhance beneficial effects patients GBM. Therefore, review aims research outcome GBM provide a more promising opportunity thoroughly exploring mechanisms investigating novel strategies.

Language: Английский

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Citronellol Induces Apoptosis via Differential Regulation of Caspase‐3, NF‐κB, and JAK2 Signaling Pathways in Glioblastoma Cell Line

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 1, 2025

Citronellol (CT) is a naturally occurring lipophilic monoterpenoid which has shown anticancer effects in numerous cancerous cell lines. This study was, therefore, designed to examine CT's potential as an agent against glioblastoma (GBM). Network pharmacology analysis was employed identify targets of CT. A comprehensive data mining carried out assess CT and GBM-associated target genes. Protein-protein interaction network constructed hub genes later GO KEGG enrichment performed elucidate the possible mechanism. Human line "SF767" used confirm silico findings. MTT, crystal violet, trypan blue assays were cytotoxic various concentrations Subsequently, ELISA qPCR analyze on proapoptotic inflammatory mediators. In findings indicated that differentially regulated pathways by activating caspase-3 8 inhibiting nuclear factor-kappa B (NF-κB), tumor necrosis factor-α, Janus kinase 2 (JAK2). Molecular docking also demonstrated strong binding affinities with above-mentioned mediators when compared 5-fluorouracil or temozolomide. SF767 line, displayed dose-dependent antioxidant effects, upregulation annexin-V, caspase-3, along downregulation modulators. nutshell, it can be concluded from these possesses robust activity mediated via differential regulation JAK2, NF-κB pathways.

Language: Английский

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Addressing the Blood-Brain Barrier: Overcoming Glioblastoma Drug Delivery

Methods in pharmacology and toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 83 - 104

Published: Jan. 1, 2025

Language: Английский

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Novel neutrophil targeting platforms in treating Glioblastoma: Latest evidence and therapeutic approaches

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 150, P. 114173 - 114173

Published: Feb. 11, 2025

Language: Английский

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The Effects of Photodynamic Therapy on Genetically Determined Glioma Syndromes Associated with an Increased Risk of Disease

Oxygen, Journal Year: 2025, Volume and Issue: 5(1), P. 2 - 2

Published: Feb. 26, 2025

Photodynamic therapy (PDT) is an effective method of preventing the progression cancer. The PDT guarantees localized generation singlet oxygen (1O2), which toxic to cells. Therefore, this treatment, also called light-activated chemotherapy, particularly useful for tumors whose location difficult access but needs be known. may alternative surgical removal tumor by replacing scalpel tool with three factors, i.e., light, a photosensitizer and oxygen, generate in cell. Herein, primary brain that probably originate from neuroglial stem or progenitor cells are discussed. In review, we have included current information on use treatment gliomas context genetics. We mainly focused study patients genetic syndromes associated increased risk glioma. review uses important diagnosis discuss association between few abnormalities. highlight molecular mechanism human cell response based literature data. treated samples, significant changes gene expression were noted after PDT.

Language: Английский

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Unraveling anoikis in glioblastoma: insights from single-cell sequencing and prognostic modeling

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 26, 2025

Despite advances, Glioblastoma (GBM) treatment remains challenging due to its rapid progression and resistance therapies. This study aimed investigate the role of anoikis—a mechanism by which cells evade programmed cell death upon detachment from extracellular matrix—in GBM prognosis. Utilizing single-cell sequencing bulk-transcriptome data TCGA, GEO, CGGA databases, we performed comprehensive bioinformatics analyses. We identified anoikis-related genes, constructed a prognostic model using 101 machine learning algorithms, validated clinical utility across multiple cohorts.Finally, also verified expression genes function key gene in samples lines. Single-cell revealed heterogeneous distinct populations within GBM. MES-like Malignant Myeloids exhibited higher enrichment these implicating their anoikis tumor aggressiveness. The model, based on effectively stratified patients into high-risk low-risk groups, demonstrating significant differences survival outcomes. Mutation microenvironment analyses highlighted genetic landscapes immune infiltration patterns associated with different risk groups. SLC43A3 emerged as gene, showing upregulation tissues correlating poor prognosis provides insights molecular mechanisms GBM, underscoring critical patient developed offers promising tool for personalized strategies warrants further exploration targeted therapies improve outcomes patients.

Language: Английский

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Advances in liquid biopsy and virtual biopsy for care of patients with glioma: a narrative review

Expert Review of Anticancer Therapy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 22

Published: April 5, 2025

The World Health Organization's 2021 classification of central nervous system neoplasms incorporated molecular and genetic features for classifying gliomas. Classification gliomas located in deep-seated structures became a clinical conundrum given the absence crucial pathological data. Advances noninvasive imaging modalities offered virtual biopsy as novel solution to this problem by identifying surrogate radiomic signatures. Liquid biopsies blood or cerebrospinal fluid provided another enormous opportunity genomic, metabolomic proteomic We summarize appraise current state evidence with regards liquid care patients PubMed, Embase Google Scholar were searched on 7/30/2024 relevant articles published after year 2013 English language. A large body preclinical preliminary suggests that is possible combined use multiple conjunction machine learning radiomics. Likewise, focused ultrasound may be valuable tool obtain genomic data regarding glioma minimally invasive manner. These will likely become an integral part future.

Language: Английский

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Effects of Asiatic acid on brain cancer by altering astrocytes and the AKT1-PRKCB signaling pathway: A genomic and network pharmacology perspective

Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149652 - 149652

Published: April 1, 2025

Language: Английский

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In Vitro and In Silico Anti-Glioblastoma Activity of Hydroalcoholic Extracts of Artemisia annua L. and Artemisia vulgaris L.

Molecules, Journal Year: 2024, Volume and Issue: 29(11), P. 2460 - 2460

Published: May 23, 2024

Glioblastoma, the most aggressive and challenging brain tumor, is a key focus in neuro-oncology due to its rapid growth poor prognosis. The C6 glioma cell line often used as glioblastoma model close simulation of human characteristics, including expansion invasiveness. Alongside, herbal medicine, particularly Artemisia spp., gaining attention for anticancer potential, offering mechanisms like apoptosis induction, cycle arrest, inhibition angiogenesis. In this study, we optimized extraction conditions polyphenols from annua L. vulgaris herbs investigated their effects silico vitro. Molecular docking main phenolic compounds A. potential target proteins, programmed death (apoptosis) pathway proteins proapoptotic Bax (PDB ID 6EB6), anti-apoptotic Bcl-2 G5M), necroptosis protein 7MON), mixed lineage kinase domain-like (MLKL), complex with receptor-interacting serine/threonine-protein 3 (RIPK3), revealed high probability interactions, highlighting possible influence chlorogenic acid modulating processes. viability rat was assessed using nuclear fluorescent double-staining assay Hoechst 33342 propidium iodide. extracts have demonstrated activity model, synergistic combined surpassing efficacy any single compound. Our results suggest these basis developing more effective treatments, emphasizing importance further research into action therapeutic applications.

Language: Английский

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Status Quo in the Liposome-Based Therapeutic Strategies Against Glioblastoma: “Targeting the Tumor and Tumor Microenvironment”

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11271 - 11271

Published: Oct. 19, 2024

Glioblastoma is the most aggressive and fatal brain cancer, characterized by a high growth rate, invasiveness, treatment resistance. The presence of blood-brain barrier (BBB) tumor (BBTB) poses challenging task for chemotherapeutics, resulting in low efficacy, bioavailability, increased dose-associated side effects. Despite rigorous strategies, including surgical resection, radiotherapy, adjuvant chemotherapy with temozolomide, overall survival remains poor. failure current chemotherapeutics other regimens glioblastoma necessitates development new drug delivery methodologies to precisely efficiently target glioblastoma. Nanoparticle-based systems offer better therapeutic option glioblastoma, considering their small size, ease diffusion, ability cross BBB. Liposomes are specific category nanoparticles made up fatty acids. Furthermore, liposomes can be surface-modified particular receptor nontoxic. This review discusses various methods liposome modification active/directed targeting liposome-based approaches chemotherapeutic drugs nucleic acids microenvironment.

Language: Английский

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