Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Nov. 14, 2024
In
this
study,
we
have
synthesized
novel
4-acetophenone
moiety-bearing
functionalized
imidazole
derivatives
containing
S-,
and
N-ethyl
substituents
evaluated
their
anticancer
activity.
Their
activity
was
studied
against
human
breast
carcinoma
(MDA-MB-231),
prostate
(PPC-1),
glioblastoma
(U-87).
Compounds
4,
9,
14,
22
were
identified
as
the
most
promising
agents
from
a
series
of
derivatives.
They
showed
highest
cytotoxicity
by
MTT
assay
MDA-MB-231,
PPC-1
U-87
cell
lines.
14
selective
lines,
EC50
values
these
lines
ranged
3.1
to
47.2
µM.
Most
tested
compounds
lower
triple-negative
cancer
MDA-MB-231
line.
None
possessed
an
inhibiting
effect
on
migration
cells
'wound'
healing
assay.
spheroid
assay,
22,
especially
in
3D
cultures.
efficiently
reduced
both
size
viability
cells.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(18), P. 9778 - 9778
Published: Sept. 10, 2024
Like
most
tumors,
glioblastoma
multiforme
(GBM),
the
deadliest
brain
tumor
in
human
adulthood,
releases
extracellular
vesicles
(EVs).
Their
content,
reflecting
that
of
origin,
can
be
donated
to
nearby
and
distant
cells
which,
by
acquiring
it,
become
more
aggressive.
Therefore,
study
EV-transported
molecules
has
very
important.
Particular
attention
been
paid
EV
proteins
uncover
new
GBM
biomarkers
potential
druggable
targets.
Proteomic
studies
have
mainly
performed
“bottom-up”
mass
spectrometry
(MS)
analysis
EVs
isolated
different
procedures
from
conditioned
media
cultured
biological
fluids
patients.
Although
a
great
number
dysregulated
identified,
translation
these
findings
into
clinics
remains
elusive,
probably
due
multiple
factors,
including
lack
standardized
for
isolation/characterization
their
proteome.
Thus,
it
is
time
change
research
strategies
adopting,
addition
harmonized
selection
techniques,
MS
methods
aimed
at
identifying
selected
tumoral
protein
mutations
and/or
isoforms
post-translational
modifications,
which
deeply
influence
behavior.
Hopefully,
data
integrated
with
those
other
“omics”
disciplines
will
lead
discovery
pathways
novel
therapies.
Journal of Neuropathology & Experimental Neurology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 19, 2024
Abstract
High-grade
infiltrating
gliomas
are
highly
aggressive
and
fatal
brain
tumors
that
present
significant
challenges
for
research
treatment
due
to
their
complex
microenvironment
tissue
structure.
Recent
discovery
of
tumor
microtubes
(TMs)
has
provided
new
insights
into
how
high-grade
develop
in
the
resist
treatment.
TMs
unique,
ultra-long,
functional
membrane
protrusions
form
multicellular
networks
play
crucial
roles
glioma
invasiveness,
drug
resistance,
recurrence,
heterogeneity.
This
review
focuses
on
different
cell
communication,
material
transport,
behavior.
Specifically,
non-connecting
primarily
promote
likely
related
role
enhancing
motility.
On
other
hand,
interconnecting
communication
by
connecting
with
surrounding
astrocytes
neurons,
thereby
promoting
malignancy.
We
summarize
factors
influence
formation
current
strategies
targeting
TMs.
As
understanding
advances,
we
closer
uncovering
whether
they
might
be
long-sought
Achilles’
heel
treatment-resistant
gliomas.
By
delving
deeper
research,
hope
more
effective
therapeutic
patients
malignant
