Protective Role of Physical Activity and Antioxidant Systems During Spermatogenesis
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(4), P. 478 - 478
Published: March 25, 2025
Oxidative
stress
is
a
significant
factor
that
contributes
to
male
infertility
and
sperm
dysfunction.
In
this
condition,
an
increase
in
ROS
production
exceeds
the
body's
antioxidant
defenses,
resulting
decline
spermatozoa
quality
fertilizing
capacity.
Furthermore,
excessive
has
been
linked
promotion
of
genomic
damage,
lipid
peroxidation,
inflammation,
altered
enzyme
activity,
ultimately,
irreversible
alterations,
cell
death,
seminal
parameters
associated
with
infertility.
It
established
physical
activity
(PA),
acting
on
inflammatory
improving
defense,
can
alleviate
negative
effects
caused
by
free
radicals,
offering
numerous
health
benefits
positively
influencing
quality.
The
objective
review
highlight
mechanisms
production,
physiological
pathophysiological
roles
relation
reproductive
system,
recent
knowledge
impact
some
protocols
PA
these
systems
molecular
involved.
Language: Английский
From infection to infertility: a review of the role of human papillomavirus-induced oxidative stress on reproductive health and infertility
European journal of medical research,
Journal Year:
2025,
Volume and Issue:
30(1)
Published: April 28, 2025
Infertility
has
emerged
as
a
significant
global
health
concern,
affecting
nearby
8-12%
of
couples
in
reproductive
age
worldwide.
Increasing
evidence
suggests
potential
link
between
human
papillomavirus
(HPV)
and
infertility
both
men
women.
Some
research
indicate
that
HPV
can
infect
various
components
semen,
potentially
sperm
quality
by
decreasing
motility,
viability,
increasing
DNA
fragmentation,
all
which
may
contribute
to
male
infertility.
The
virus
attach
the
equatorial
region
head,
enabling
infected
transmit
oocyte
or
placenta.
Consequently,
induces
apoptosis
trophoblastic
cells
disrupts
their
adhesion
endometrial
cells,
raises
risk
miscarriage.
also
affect
ovarian
reserve
causing
chronic
inflammation,
impair
granulosa
cell
function
lower
serum
anti-Müllerian
hormone
(AMH)
levels.
Besides,
HPV-related
immune
responses
producing
anti-sperm
antibodies
(ASAs),
cause
clumping,
reduce
motility
through
cervical
mucus,
activate
complement
system
damages
female
tract
interfere
with
sperm-egg
interactions.
Moreover,
infection
been
linked
reduced
success
rates
assisted
technologies
(ART),
disrupting
critical
processes
such
acrosome
reaction,
sperm-oocyte
interaction,
fusion.
One
mechanism
contributes
is
oxidative
stress
(OS).
Triggered
OS
negatively
impact
damage
system,
ultimately
contributing
Despite
these
associations,
precise
mechanisms
strength
relationship
remain
uncertain.
Thus,
this
review
seeks
investigate
on
infertility,
particularly
its
effects
OS.
A
clearer
understanding
could
inform
future
strategies
for
addressing
Language: Английский
“Unraveling the Clot-Miscarriage Nexus: Mechanisms, Management, and Future Directions in Thrombosis-Related Recurrent Pregnancy Loss”
Clinical and Applied Thrombosis/Hemostasis,
Journal Year:
2025,
Volume and Issue:
31
Published: April 1, 2025
Recurrent
spontaneous
abortion
(RSA)
is
a
multifactorial
condition
influenced
by
genetic,
hormonal,
immunological,
and
anatomical
factors.
Thrombophilia,
characterized
heightened
propensity
for
blood
clotting,
significant
contributor
to
RSA.
This
review
examines
the
mechanisms
connecting
thrombosis
RSA,
focusing
on
hypercoagulable
states,
placental
thrombosis,
inflammation,
endothelial
dysfunction.
Genetic
acquired
thrombophilic
factors,
such
as
factor
V
Leiden
mutation,
prothrombin
gene
protein
C
S
deficiencies,
antithrombin
III
deficiency,
antiphospholipid
syndrome,
hyperhomocysteinemia,
are
discussed
in
detail.
The
diagnosis
of
thrombophilia
RSA
entails
comprehensive
clinical
evaluation,
including
assessment
physical
examination,
medical
history
laboratory
investigations,
although
there
still
debate
over
need
universal
screening.
Therapeutic
strategies,
anticoagulant
antiplatelet
therapies,
well
lifestyle
modifications,
tailored
individual
risk
factors
disease
severity.
Although
therapy
demonstrates
potential
lowering
miscarriage,
additional
research
necessary
refine
treatment
protocols
assess
long-term
outcomes.
highlights
nuanced
approach
managing
thrombophilia-associated
balancing
diagnostic
precision
with
therapeutic
efficacy
improve
reproductive
Language: Английский