Effect of long-term care and pandemic wave on relative risk of COVID-19-related infection, hospitalization and mortality in people living with dementia: A population-based cohort study DOI Creative Commons
Andrea Olmstead,

Shengjie Zhang,

Larry Shaver

et al.

Journal of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Background People living with dementia (PLWD) are vulnerable to serious COVID-19 illness and death but the contribution of various factors including long-term care (LTC), pandemic wave, hospitalization, comorbidities, underlying neurological health remains unclear. Objective To investigate relative risk SARS-CoV-2 infection, mortality (COVID-19 non-COVID-19) in PLWD compared those without dementia, by circumstance while controlling for additional factors. Methods A cohort people 65 up Alzheimer's disease, was propensity score matched a control using linked population-level records. Relative outcomes estimated adjusted Cox proportional hazards modelling. The modifying effects LTC residence wave on all outcomes, COVID-19-related hospitalization were investigated. Results Compared controls had higher infection whether they lived or not. For LTC, often reduced not significantly different when stratified remained (32–93%). In likelihood 53–64% lower dementia. hospitalized than non-hospitalized, non-dementia both (32% 477%, respectively). Conclusions repeatedly mortality, varied changing circumstances environment. Higher may have been associated hospital transfers, complex needs health.

Language: Английский

Effect of long-term care and pandemic wave on relative risk of COVID-19-related infection, hospitalization and mortality in people living with dementia: A population-based cohort study DOI Creative Commons
Andrea Olmstead,

Shengjie Zhang,

Larry Shaver

et al.

Journal of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Background People living with dementia (PLWD) are vulnerable to serious COVID-19 illness and death but the contribution of various factors including long-term care (LTC), pandemic wave, hospitalization, comorbidities, underlying neurological health remains unclear. Objective To investigate relative risk SARS-CoV-2 infection, mortality (COVID-19 non-COVID-19) in PLWD compared those without dementia, by circumstance while controlling for additional factors. Methods A cohort people 65 up Alzheimer's disease, was propensity score matched a control using linked population-level records. Relative outcomes estimated adjusted Cox proportional hazards modelling. The modifying effects LTC residence wave on all outcomes, COVID-19-related hospitalization were investigated. Results Compared controls had higher infection whether they lived or not. For LTC, often reduced not significantly different when stratified remained (32–93%). In likelihood 53–64% lower dementia. hospitalized than non-hospitalized, non-dementia both (32% 477%, respectively). Conclusions repeatedly mortality, varied changing circumstances environment. Higher may have been associated hospital transfers, complex needs health.

Language: Английский

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