Advancements in bioengineering for descemet membrane endothelial keratoplasty (DMEK)

npj Regenerative Medicine, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 14, 2025

Abstract Corneal diseases are the third leading cause of blindness worldwide. Descemet’s Membrane Endothelial Keratoplasty (DMEK) is preferred surgical technique for treating corneal endothelial disorders, relying heavily on high-quality donor tissue. However, scarcity suitable tissue and sensitivity cells remain significant challenges. This review explores current state DMEK, focusing advancements in engineering as a promising solution to improve outcomes address limitations.

Language: Английский

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Machine learning in ocular oncology and oculoplasty: Transforming diagnosis and treatment

IP International Journal of Ocular Oncology and Oculoplasty, Journal Year: 2025, Volume and Issue: 10(4), P. 196 - 207

Published: Jan. 14, 2025

In the domains of ocular oncology and oculoplasty, machine learning (ML) has become a game-changing technology, providing previously unheard-of levels precision in diagnosis, treatment planning, outcome prediction. Using imaging modalities, genomic data, clinical characteristics, this chapter investigates integration algorithms detection tumours, including retinoblastoma uveal melanoma. Through predictive modelling real-time decision-making, it also emphasises how ML might improve surgical outcomes orbital reconstruction eyelid correction. Automated examination fundus photographs, histological slides, 3D been made possible by methods like deep natural language processing, which have improved individualised therapeutic approaches decreased diagnostic errors. Additionally, use augmented reality robotics surgery is significant development oculoplasty. Notwithstanding its potential, issues data heterogeneity, algorithm interpretability, ethical considerations are roadblocks that need to be addressed. This explores cutting-edge developments, real-world uses, potential future paths, offering researchers doctors thorough resource. Dipali Vikas Mane, Associate Professor, Shriram Shikshan Sanstha’s College Pharmacy, Paniv-413113

Language: Английский

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Three-Dimensional Printing for Accessible and Personalized Ophthalmic Care: A Review

Journal of Clinical & Translational Ophthalmology, Journal Year: 2025, Volume and Issue: 3(2), P. 6 - 6

Published: March 26, 2025

Over 2.2 billion people across the globe face significant barriers to accessing essential ophthalmic care, with elderly, rural, and refugee populations being disproportionately affected, deepening existing disparities in eye care. Three-dimensional printing is a novel technology that has potential transform field improve access by alleviating many patient-specific barriers. This article delves into evolution of 3D within ophthalmology, highlighting its current applications future potential. It explores various techniques numerous biomaterials discussing their effectiveness creating advanced solutions such as bioengineered corneas, ocular prosthetics, innovative treatments for dry syndrome, from punctal plugs lacrimal gland models. Additionally, revolutionized drug delivery systems conditions like glaucoma, retinal diseases, brachytherapy. Whether through printed contact lens-based or polycaprolactone implants biodegrade provide sustained release without adverse effects, these hold immense field. Despite promise, integration clinical practice presents challenges, which addresses alongside strategies overcoming them. By mapping out technological advancements this review offers roadmap enhancing global care accessibility improving patient outcomes on scale.

Language: Английский

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Optical properties of artificial intraocular lenses and considerations for additive manufacturing

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: April 14, 2025

Cataracts, a leading cause of blindness in the world, are commonly treated by replacing ocular lens with an artificial intraocular (IOL). The material and structure IOL major factors their efficacy, affecting, among other characteristics, optics eye. In recent research record, two optical properties have emerged as standardized characterization methods for optics: (1) transmittance (2) scattering. This mini review describes these collates data such way that comparisons may be drawn across four different types (PMMA, hydrophobic acrylic, hydrophilic silicone) three conditions ( in-vivo , cadaver explant, inventory control). Finally, emerging field additive manufacturing production is considered. Such technologies hold promise optimizing IOLs cataract patients. Researchers incorporate scattering standard 3D-printed developed broader researcher community.

Language: Английский

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A Case for the Optimization of Ophthalmic Care by Leveraging 3-D Printing: A Review

Published: Aug. 29, 2024

Over 2.2 billion people across the globe face significant barriers to accessing essential ophthalmic care, with elderly, rural, and refugee populations being disproportionately affected. These obsta-cles deepen existing disparities in eye care. 3D printing is a novel technology that has potential transform field improve access through alleviating many patient-specific barriers. This article delves into evolution of within ophthalmology, highlighting its current ap-plications future potential. It explores various techniques biomaterials, dis-cussing their effectiveness creating advanced solutions such as bioengineered corneas, ocular prosthetics, innovative treatments for dry syndrome. Additionally, rev-olutionized drug delivery systems conditions like glaucoma, retinal diseases, brachytherapy. Despite promise, integration clinical practice presents challenges, which addresses alongside strategies overcoming them. By mapping out technological advancements this review offers roadmap enhancing global care accessibility improving patient outcomes on scale.

Language: Английский

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Progress in 3D Printing Applications for the Management of Orbital Disorders: A Systematic Review

Bioengineering, Journal Year: 2024, Volume and Issue: 11(12), P. 1238 - 1238

Published: Dec. 7, 2024

Introduction: 3D printing technology has gained considerable interest in the domain of orbital illnesses owing to its capacity transform diagnosis, surgery planning, and treatment. This systematic review seeks deliver a thorough examination contemporary applications treatment ocular problems, encompassing tumors, injuries, congenital defects. recent studies examined application patient-specific 3D-printed models for preoperative personalized implants, prosthetics. Methods: was conducted according PRISMA guidelines. The PICOS is “What are current advances management pathology?” databases analyzed research phase MEDLINE, Embase, Cochrane Central Register Controlled Trials (CENTRAL), ClinicalTrials.gov, ScienceDirect, Scopus, CINAHL, Web Science. Results: Out 314 found literature, only 12 met inclusion exclusion criteria. From included studies, it evident that can be useful trauma oncological pathologies region. Discussion: proves very mainly purpose improving planning surgical procedure, allowing better preparation by team reduction operative time complications. Conclusions: proven an outstanding tool orbit pathology. Comparing advantages disadvantages such technology, former far outweigh latter.

Language: Английский

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A Review of 3D Printing by Robocasting and Stereolithography for Cartilage and Ocular Tissue Regeneration

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Abstract The advent of 3D printing technologies has led to a new era in tissue regeneration, offering unparalleled precision and versatility fabricating scaffolds for various biomedical applications. Robocasting stereolithography stand out among these their distinct advantages engineering complex structures. Robocasting, an extrusion-based technique, shown significant promise cartilage engineering. Its ability precisely deposit biomaterials layer-by-layer allows the creation porous with encapsulated cells bioactive molecules that improve mechanical properties biological functionality. These support proliferation differentiation chondrocytes or mesenchymal stem cells, facilitating regeneration damaged cartilage. Stereolithography, light-based offers remarkable resolution accuracy highly detailed structures closely resemble architecture tissues. This makes it particularly suitable treatments injuries diseases ocular regeneration. Integrating robocasting presents synergistic approach replicating tissues' physical environments, innovative regenerative therapies. review highlights recent advancements potential medicine, focusing on applications Graphical

Language: Английский

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Study of the Factors on Controlling Cured Layer Thickness in DLP 3D Printing

Key engineering materials, Journal Year: 2024, Volume and Issue: 1006, P. 15 - 20

Published: Dec. 26, 2024

Digital Light Processing (DLP) 3D printing is an additive manufacturing technique that uses a digital light projector to cure photopolymer resin layer-by-layer create high-precision solid structures. In addition the planar resolution, control of curing depth has critical impact on success precise and geometric features printed product. This issue aggravated in case projection micro-stereolithography (PμSL), which objective lens enhance resolution projected pattern. this study, we investigated possible measures cured layer thickness from both material optical perspectives. As-received commercial was used obtain raw thickness, then Sudan I or carbon black added separately study their effects. Eventually, grayscale exposed pattern adjusted reduce intensity achieve thinner thickness. Combining above reduced single-layer 250 μm 5.8 μm, approaching usual minimum dimension setting 5 μm. By exploring variables affecting findings are expected improve DLP technology producing high-resolution structures, especially z-direction.

Language: Английский

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