Evaluation of hepatoprotective and nephroprotective activities of Castanopsis costata extract in rats DOI Open Access
Maulana Yusuf Alkandahri, Asman Sadino,

Ermi Abriyani

et al.

Biomedical Reports, Journal Year: 2024, Volume and Issue: 22(2)

Published: Dec. 4, 2024

The liver and kidneys are important organs for body homeostasis but susceptible to damage or injury caused by different factors. A number of medicinal plants, such as Castanopsis costata have been proven effective in protecting the from damage. Therefore, present study aimed examine effect C. extract (CcE) on paracetamol‑induced hepatotoxicity gentamicin‑induced nephrotoxicity rat model. Each treatment group was given CcE at doses 100, 200 400 mg/kg 21 8 days hepatoprotective tests nephroprotective tests, respectively. To induce kidney damage, rats were paracetamol 1,000 orally 7 (15‑21) gentamicin 80 intraperitoneally 5 (4‑8) days. assess function, levels aspartate aminotransferase (AST), alanine (ALT), alkaline phosphatase (ALP), total bilirubin (TB), cholesterol (TC), albumin (TA) protein (TP) measured, well antioxidant enzymes. Meanwhile, serum creatinine (SCr), urea (SU) uric acid (UA) measured. TNF‑α IFN‑γ also measured with histopathology testing effects organ each experiment. results showed that reduced AST, ALT, ALP, TB TC, increased TA, TP enzymes, reducing SCr, SU UA when compared pathological group. Additionally, IFN‑γ, improving structure tissue confirmed histopathology. had rats,

Language: Английский

Global hotspots and trends of nutritional supplements for sick populations from 2000 to 2024 DOI Creative Commons

Chaofan Shi,

Haitao Liu,

Te Fu

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 28, 2025

Background Nutritional supplements (NS) can help patients by providing various nutrients such as essential vitamins and minerals, helping to prevent recover from diseases. This study provides a broad overview of the field NS for sick people through bibliometrics visualization analysis, analyze status development dynamics, explore popular research questions directions, reveal trends frontiers. Methods We searched Web Science Core Collection databases literature related diseased populations 2000 2024. A total 1,550 articles were included in analysis after screening. Analyses performed using CiteSpace VOSviewer software. Results The population has witnessed an overall rapid growth number publications, which is divided into three phases: 2000–2008 was exploratory phase, 2009–2017 sustained 2018 date phase. Research focuses on dietary supplementation, oxidative stress, vitro injections, development, antioxidant activity, double-blind trials, lipid supplements, functional foods, health populations, risks NS. Conclusion Different each possess unique benefits should be chosen according type disease ensure they contain corresponding nutrients. Vitamin are widely mentioned among patient across globe. Future may focus applying nutritional gut microbiota bioactive compounds. Researchers frequently mention application women, infants, children. It continue monitored optimized future enhance its therapeutic effects, thereby accelerating patients’ recovery improving their quality life.

Language: Английский

Citations

0
Exploring the Correlation Between Vitamin D Levels and Serological Markers in Liver Diseases: Insights from a Cross-Sectional Study DOI Open Access

Adina Ioana Mihele,

Sergiu Cristian Hocopan,

Sergiu Dorin Matei

et al.

In Vivo, Journal Year: 2024, Volume and Issue: 38(5), P. 2271 - 2283

Published: Jan. 1, 2024

This study investigated the correlation between vitamin D levels and serological markers of liver diseases in two groups patients: control group (CG) (SG).

Language: Английский

Citations

1
QUALITY OF LIFE ASSESSMENT IN PATIENTS WITH CHRONIC LIVER DISEASE USING THE COMBINED MULTIDIMENSIONAL QUESTIONNAIRE SF-LDQOL, INCLUDING COMPLEMENTARY QUESTIONS DOI Creative Commons
Monica Foghis, Delia Mirela Ţiţ,

Andreea Monica Foghis

et al.

Archives of the Balkan Medical Union, Journal Year: 2024, Volume and Issue: 59(1), P. 75 - 82

Published: March 20, 2024

Évaluation de la qualité vie des patients souffrant d'une maladie chronique du foie à l'aide questionnaire multidimensionnel combine SF-LDQOL incluant questions complémentairesIntroduction.Les maladies hépatiques chroniques constituent un problème santé publique important avec impact négatif majeur sur tous les aspects patients.Les conséquences sont directement liées hépatique chronique, mais également au traitement administré.L'objectif l'étude était d'évaluer atteints SF-LDQOL, comprenant complémentaires l'utilisation suppléments nutritionnels.Matériels et méthodes.Une analyse transversale diagnostic confirmé (CLD), court groupe 40 a été réalisée.Les données ABSTRACT Introduction.Chronic liver disease is an public health problem with major negative on all of patients' lives.The consequences are directly related to the chronic disease, but also administered treatment.The objective study was evaluate quality life in diseases by using questionnaire, including complementary use nutritional supplements.Materials and methods.A cross-sectional analysis confirmed diagnosis short form group conducted.Data CLD (age, sex, activity, risk factors, clinical symptoms, hepatoprotective supplements (NS)) were collected analyzed.Results.The mean age participants 68.34±14.45years.The general status moderate mild studied group.In most cases, linear frequency shows

Citations

0
Evaluation of hepatoprotective and nephroprotective activities of Castanopsis costata extract in rats DOI Open Access
Maulana Yusuf Alkandahri, Asman Sadino,

Ermi Abriyani

et al.

Biomedical Reports, Journal Year: 2024, Volume and Issue: 22(2)

Published: Dec. 4, 2024

The liver and kidneys are important organs for body homeostasis but susceptible to damage or injury caused by different factors. A number of medicinal plants, such as Castanopsis costata have been proven effective in protecting the from damage. Therefore, present study aimed examine effect C. extract (CcE) on paracetamol‑induced hepatotoxicity gentamicin‑induced nephrotoxicity rat model. Each treatment group was given CcE at doses 100, 200 400 mg/kg 21 8 days hepatoprotective tests nephroprotective tests, respectively. To induce kidney damage, rats were paracetamol 1,000 orally 7 (15‑21) gentamicin 80 intraperitoneally 5 (4‑8) days. assess function, levels aspartate aminotransferase (AST), alanine (ALT), alkaline phosphatase (ALP), total bilirubin (TB), cholesterol (TC), albumin (TA) protein (TP) measured, well antioxidant enzymes. Meanwhile, serum creatinine (SCr), urea (SU) uric acid (UA) measured. TNF‑α IFN‑γ also measured with histopathology testing effects organ each experiment. results showed that reduced AST, ALT, ALP, TB TC, increased TA, TP enzymes, reducing SCr, SU UA when compared pathological group. Additionally, IFN‑γ, improving structure tissue confirmed histopathology. had rats,

Language: Английский

Citations

0