Association between body roundness index and psoriasis: a cross-sectional study

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 28, 2025

This study aimed to elucidate the association between body roundness index (BRI), an indicator of abdominal obesity, and odds developing psoriasis. We conducted a comprehensive, multi-ethnic cross-sectional analysis utilizing data from National Health Nutrition Examination Survey (NHANES). Height weight measurements were obtained database, recorded by trained personnel using standardized equipment. In addition, demographic clinical information was collected via questionnaires. The BRI psoriasis assessed multivariable weighted logistic regression models, relationship further visualized through restricted cubic spline (RCS) curves. Subgroup analyses explore this across different populations, sensitivity performed unweighted methods validate findings. encompassed 21,242 participants, whom 562 diagnosed with Comparative characteristics non-psoriasis groups revealed statistically significant differences. demonstrated positive occurrence psoriasis, considered both as continuous categorical variable. Specifically, each unit increase in associated 9% (95% confidence interval: 4% 13%). RCS curves indicated progressive rising levels. consistently showed correlation diverse populations. corroborated main findings, underscoring robustness our conclusions. Our findings establish reliable BRI, marker various

Language: Английский

Age, sex, and APOE gene-specific associations between dynapenic obesity and dementia in a large cohort

The journal of nutrition health & aging, Journal Year: 2024, Volume and Issue: 28(8), P. 100313 - 100313

Published: July 9, 2024

To investigate the associations between dynapenic obesity and risk of dementia, modifying effects age, sex, APOE gene, using a large population-based cohort. 279,884 participants aged 55 above from UK Biobank were included. The classified into four categories based on body mass index hand grip strength: healthy, obesity, dynapenia, obesity. incident dementia was identified linked hospital records death register data. Cox proportional hazards regression models used to estimate associations, followed by age-, sex-, apolipoprotein E (APOE) gene-stratified analyses. During median follow-up 12.4 years, 5,170 (1.8%) developed dementia. Compared with healthy group, had 67% higher (hazard ratio [HR]: 1.67, 95% confidence interval [CI]: 1.44–1.94). risks in respectively observed male (HR: 2.03, CI: 1.65–2.50), younger (<65 HR: 1.97, 1.55–2.50), non-ε4-carrier 1.60–2.44) (all P for interaction <0.05). In under 65 years non-ε4-carrier, those highest 2.63, 1.91–3.62), compared group (P second order = 0.026). Dynapenic is associated increased especially suggesting importance managing prevention cognition-related disorders.

Language: Английский