Extracellular acyl-CoA-binding protein as an independent biomarker of COVID-19 disease severity

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

Factors leading to severe COVID-19 remain partially known. New biomarkers predicting severity that are also causally involved in disease pathogenesis could improve patient management and contribute the development of innovative therapies. Autophagy, a cytosolic structure degradation pathway is maintenance cellular homeostasis, intracellular pathogens generation energy for immune responses. Acyl-CoA binding protein (ACBP) key regulator autophagy context diabetes, obesity anorexia. The objective our work was assess whether circulating ACBP levels associated with severity, using proteomics data from plasma 903 patients. Somalogic proteomic analysis used detect 5000 proteins samples collected between March 2020 August 2021 hospitalized participants province Quebec, Canada. Plasma patients during their admission acute phase 295 controls were assessed 1198 interpretable profiles. Levels anti-SARS-CoV-2 IgG measured by ELISA cell-binding assay. median age 59 years, 46% female, 65% had comorbidities. correlated association inflammation antibody levels, independently sex or presence Samples second wave Quebec higher than first wave. negatively T NK cell responses interferon-γ, tumor necrosis factor-α interleukin-21, age, sex, severity. Circulating can be considered biomarker linked inflammation. contribution extracellular immunometabolic viral infection should further studied.

Language: Английский

Advanced time complexity analysis for real-time COVID-19 prediction in Saudi Arabia using LightGBM and XGBoost

Journal of Radiation Research and Applied Sciences, Journal Year: 2025, Volume and Issue: 18(2), P. 101364 - 101364

Published: Feb. 18, 2025

Language: Английский