A blood supply pathophysiological microcirculatory mechanism for the Long COVID

Published: July 30, 2024

Background: The term “Long COVID” is commonly used to describe persisting symptoms after acute COVID‑19. Until now, proposed mechanisms for the explanation of Long COVID have not related quantitative measurements basic laws. In this work, a common framework pathophysiological mechanism presented, based on blood supply deprivation and flow diffusion equation. Methods: Case-control studies with statistically significant differences between cases (post-COVID patients) controls, from multiple tissues geographical areas, were gathered tabulated. Microvascular loss (ML) was quantified by vessel density reduction (VDR), foveal avascular zone enlargement (FAZE), capillary (CDR), percentage perfused vessels (PPVR). Both ML hemodynamic decrease (HD), incorporated in tissue (SR) estimation. Results: data found 763 post-COVID patients an average VDR, FAZE, CDR, PPVR 16%, 31%, 14%, 21%, respectively. HD 72 37%. estimated SR 634 reached sizeable 47%. This large creates conditions lower mass rates, hypoxia, undernutrition, which at multi-tissue level, long time, can explain wide variety symptoms. Conclusions: Disruption peripheral contribution both here be principal cause leading

Language: Английский

---

SIRT1: A likely key for future therapeutic strategies for pain management

Pharmacological Research, Journal Year: 2025, Volume and Issue: 213, P. 107670 - 107670

Published: Feb. 20, 2025

Sirtuin 1 (SIRT1), a NAD+ -dependent histone deacetylase, plays crucial role in mitigating oxidative stress, regulating inflammation, and maintaining mitochondrial function. Reduced SIRT1 activity has been linked to elevated pro-inflammatory cytokines, dysfunction, chronic pain, all of which are observed long COVID pathology. Emerging evidence identifies dysfunction stress as central contributors these symptoms. Increases reactive oxygen species (ROS) such superoxide, nitric oxide, peroxynitrite, leading damage, central/peripheral sensitization. Nutraceuticals, particularly the polyphenolic fraction bergamot (BPF), have demonstrated potent antioxidant, anti-inflammatory, antiviral properties. This study highlights BPF's ability modulate rat model inflammation hyperalgesia. It provides novel nitration within nucleus key event inflammatory pain pathogenesis. BPF administration preserved activity, reduced markers malondialdehyde (MDA) 8-hydroxydeoxyguanosine (8-OHdG), minimized post-translational modifications nuclear proteins, including nitration, acetylation, carbonylation. Additionally, it alleviated hyperalgesia allodynia. These findings underscore therapeutic potential polyphenols like reducing inflammation-driven pain. By activating SIRT1, may provide relief for conditions. Further research on SIRT1-targeted therapies is essential combat preventing conditions enhancing treatment options.

Language: Английский

---

Developing a clinical-pathological framework of long COVID-related fatigue applied to public safety workers

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: July 17, 2024

In the wake of COVID-19 pandemic, millions worldwide are still struggling with persistent or recurring symptoms known as long COVID. Fatigue is one most prevalent associated COVID, and for many it can be debilitating. Understanding potential pathological processes that link fatigue to COVID critical better guide treatment. Challenges diagnosis treatment reviewed, recognizing post-COVID does not always present corroborating clinical evidence, a situation frustrating both patients healthcare providers. Firefighters group public safety workers who particularly impacted by COVID-related fatigue. must able engage in strenuous physical activity deal demanding psychological situations, which may difficult those suffering from Disruption worker health potentially impact community welfare. This review creates framework explain clinical-pathological features resulting addresses challenges, explores unique pose their organizations.

Language: Английский

---

A Blood Supply Pathophysiological Microcirculatory Mechanism for Long COVID

Life, Journal Year: 2024, Volume and Issue: 14(9), P. 1076 - 1076

Published: Aug. 28, 2024

Background: The term “Long COVID” is commonly used to describe persisting symptoms after acute COVID-19. Until now, proposed mechanisms for the explanation of Long COVID have not related quantitative measurements basic laws. In this work, a common framework pathophysiological mechanism presented, based on blood supply deprivation and flow diffusion equation. Methods: Case–control studies with statistically significant differences between cases (post-COVID patients) controls, from multiple tissues geographical areas, were gathered tabulated. Microvascular loss (ML) was quantified by vessel density reduction (VDR), foveal avascular zone enlargement (FAZE), capillary (CDR), percentage perfused (PPVR). Both ML hemodynamic decrease (HD) incorporated in tissue (SR) estimation. Results: data found 763 post-COVID patients an average VDR, FAZE, CDR, PPVR 16%, 31%, 14%, 21%, respectively. HD 72 37%. estimated SR 634 reached sizeable 47%. This large creates conditions lower mass rates, hypoxia, undernutrition, which at multi-tissue level, long time, can explain wide variety symptoms. Conclusions: Disruption peripheral contribution both here be principal cause leading

Language: Английский

---

A Mixed Methods Analysis of Long COVID Symptoms in Black Americans: Examining Physical and Mental Health Outcomes

Journal of Racial and Ethnic Health Disparities, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 24, 2024

Language: Английский

---

The negative effects of long COVID-19 on cardiovascular health and implications for the presurgical examination

Journal of Osteopathic Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 17, 2024

In 2019, emergence of the novel and communicable severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection took scientific communities by surprise imposed significant burden on healthcare systems globally. Although advent this disease piqued interest academic centers, systems, general public, there is still much yet to be elucidated regarding epidemiology, pathophysiology, long-term impacts 2019 (COVID-19). It has been established that long COVID-19 can impact multiple organ including cardiovascular system, unfavorably. pathophysiology damage not well understood, adverse sequelae may range from chest pain arrhythmias heart failure (HF), myocardial infarction, or sudden cardiac death. For any postacute patient requiring a surgical procedure, potential for injury secondary must considered in preoperative examination.

Language: Английский

---

INTERSEÇÃO VIRAL: ANÁLISE DOS EFEITOS NEUROLÓGICOS PÓS-COVID NO SISTEMA NERVOSO

Published: March 5, 2024

---

OS EFEITOS DA CL EM OUTROS SISTEMAS CORPORAIS

Published: March 5, 2024

---

INTRODUÇÃO

Published: March 5, 2024

---

COVID-19 E O SISTEMA IMUNOLÓGICO

Published: March 5, 2024

---