2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS)

European Heart Journal, Journal Year: 2022, Volume and Issue: 43(41), P. 4229 - 4361

Published: Aug. 26, 2022

65-74 years, Sex category (female) CIED Cardiac implantable electronic device CML Chronic myeloid leukaemia CMR magnetic resonance COMPASS-CAT Prospective COmparison of Methods for thromboembolic

Language: Английский

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Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases

Frontiers in Physiology, Journal Year: 2020, Volume and Issue: 11

Published: July 2, 2020

Oxidative stress plays an essential role in the pathogenesis of chronic diseases such as cardiovascular diseases, diabetes, neurodegenerative and cancer. Long term exposure to increased levels pro-oxidant factors can cause structural defects at a mitochondrial DNA level, well functional alteration several enzymes cellular structures leading aberrations gene expression. The modern lifestyle associated with processed food, wide range chemicals lack exercise important oxidative induction. However, use medicinal plants antioxidant properties has been exploited for their ability treat or prevent human pathologies which seems be one causes. In this review we discuss is triggers plant-derived compounds mechanisms defenses that help prevention these diseases. Finally, both beneficial detrimental effects molecules are used reduce conditions discussed.

Language: Английский

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Potential Health Benefits of Plant Food-Derived Bioactive Components: An Overview

Foods, Journal Year: 2021, Volume and Issue: 10(4), P. 839 - 839

Published: April 12, 2021

Plant foods are consumed worldwide due to their immense energy density and nutritive value. Their consumption has been following an increasing trend several metabolic disorders linked non-vegetarian diets. In addition value, plant contain bioactive constituents that have shown possess health-promoting properties. Plant-derived compounds, such as biologically active proteins, polyphenols, phytosterols, biogenic amines, carotenoids, etc., reported be beneficial for human health, instance in cases of cancer, cardiovascular diseases, diabetes, well people with gut, immune function, neurodegenerative disorders. Previous studies components antioxidative, anti-inflammatory, immunomodulatory properties, improving intestinal barrier functioning which contribute ability mitigate the pathological impact various diseases. This review describes derived from fruit, vegetables, cereals, other sources health promoting attributes, mechanisms responsible properties some these components. mainly compiles potential food providing information researchers may valuable devising future strategies choosing promising ingredients make functional non-communicable

Language: Английский

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<p>Obesity paradox in cardiovascular disease: where do we stand?</p>

Vascular Health and Risk Management, Journal Year: 2019, Volume and Issue: Volume 15, P. 89 - 100

Published: April 30, 2019

Obesity is associated with an increased risk of developing cardiovascular disease (CVD), particularly heart failure (HF) and coronary (CHD). The mechanisms through which obesity increases CVD involve changes in body composition that can affect hemodynamics alters structure. Pro-inflammatory cytokines produced by the adipose tissue itself induce cardiac dysfunction promote formation atherosclerotic plaques. When HF or CHD coexist, individuals class I present a more favorable prognosis compared to who are normal underweight. This phenomenon has been termed "obesity paradox." defined as excess fat mass (FM), but typically also amount lean (LM). increase LM may explain part paradox it improved cardiorespiratory fitness (CRF), major determinant clinical outcomes general population, those CVD, including HF. While stronger prognosticator FM, patients FM exert protective effects when not systemic inflammation. In review, we discuss for how setting established focus on composition. We highlight importance measuring estimating CRF, composition-adjusted measures CRF (ie, peak oxygen consumption) status stratification finally, potential non-pharmacologic therapeutics, such exercise training dietary interventions, aimed at improving perhaps outcomes.

Language: Английский

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Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits

Oxidative Medicine and Cellular Longevity, Journal Year: 2021, Volume and Issue: 2021(1)

Published: Jan. 1, 2021

Genistein is an isoflavone first isolated from the brooming plant Dyer's Genista tinctoria L. and widely distributed in Fabaceae family. As isoflavone, mammalian genistein exerts estrogen-like functions. Several biological effects of have been reported preclinical studies, such as antioxidant, anti-inflammatory, antibacterial, antiviral activities, angiogenesis estrogen, pharmacological activities on diabetes lipid metabolism. The purpose this review to provide up-to-date evidence with mechanisms action, bioavailability, clinical genistein. literature was researched using most important keyword "genistein" PubMed, Science, Google Scholar databases, taxonomy validated Plant List. Data were also collected specialized books other online resources. main positive refer protection against cardiovascular diseases decrease incidence some types cancer, especially breast cancer. Although mechanism cancer involves several aspects metabolism, researchers attribute effect similarity between structure soy that estrogen. This structural allows displace estrogen cellular receptors, thus blocking their hormonal activity. resulting experimental studies support traditional uses genistein, but future, further investigations are needed efficacy, safety, use nanotechnologies increase bioavailability therapeutic efficacy.

Language: Английский

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Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 11

Published: Jan. 18, 2021

Chalcones are among the leading bioactive flavonoids with a therapeutic potential implicated to an array of bioactivities investigated by series preclinical and clinical studies. In this article, different scientific databases were searched retrieve studies depicting biological activities chalcones their derivatives. This review comprehensively describes on derivatives describing immense significance as antidiabetic, anticancer, anti-inflammatory, antimicrobial, antioxidant, antiparasitic, psychoactive, neuroprotective agents. Besides, trials revealed use in treatment chronic venous insufficiency, skin conditions, cancer. Bioavailability indicate possible hindrance improvement relation its nutraceutical pharmaceutical applications. Multifaceted complex underlying mechanisms chalcone actions demonstrated ability modulate number cancer cell lines, inhibit pathological microorganisms parasites, control signaling molecules cascades related disease modification. Clinical general absence adverse effects besides reducing signs symptoms decent bioavailability. Further needed elucidate structure activity, toxicity concerns, cellular basis mode action, interactions other molecules.

Language: Английский

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The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action

Frontiers in Pharmacology, Journal Year: 2020, Volume and Issue: 11

Published: Aug. 26, 2020

Anthocyanins are natural phenolic pigments with biological activity. They well-known to have potent antioxidant and anti-inflammatory activity, which explains the various effects reported for these substances suggesting their antidiabetic anticancer activities, role in cardiovascular neuroprotective prevention. This review aims comprehensively analyze different studies performed on this class of compounds, bioavailability therapeutic potential. An in-depth look preclinical, vitro vivo, clinical indicates preventive anthocyanins cardioprotection, neuroprotection, anti-obesity as well antidiabetes effects.

Language: Английский

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Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment

Cancer Cell International, Journal Year: 2021, Volume and Issue: 21(1)

Published: June 24, 2021

Abstract The study describes the current state of knowledge on nanotechnology and its utilization in medicine. focus this manuscript was properties, usage safety, potentially valuable applications chitosan-based nanomaterials. Chitosan nanoparticles have high importance nanomedicine, biomedical engineering, discovery development new drugs. reviewed studies regarding use for creating release systems with improved bioavailability, increased specificity sensitivity, reduced pharmacological toxicity Nowadays, effective cancer treatment is a global problem, recent advances nanomedicine are great importance. Special attention put application chitosan developing system anticancer drug delivery. Pre-clinical clinical support nanomedicine. This overviews last progresses utilization, stability, bioavailability nanoencapsulation their safety.

Language: Английский

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2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS)

European Heart Journal - Cardiovascular Imaging, Journal Year: 2022, Volume and Issue: 23(10), P. e333 - e465

Published: Aug. 26, 2022

Language: Английский

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Dietary Flavonoids: Cardioprotective Potential with Antioxidant Effects and Their Pharmacokinetic, Toxicological and Therapeutic Concerns

Molecules, Journal Year: 2021, Volume and Issue: 26(13), P. 4021 - 4021

Published: June 30, 2021

Flavonoids comprise a large group of structurally diverse polyphenolic compounds plant origin and are abundantly found in human diet such as fruits, vegetables, grains, tea, dairy products, red wine, etc. Major classes flavonoids include flavonols, flavones, flavanones, flavanols, anthocyanidins, isoflavones, chalcones. Owing to their potential health benefits medicinal significance, now considered an indispensable component variety medicinal, pharmaceutical, nutraceutical, cosmetic preparations. Moreover, play significant role preventing cardiovascular diseases (CVDs), which could be mainly due antioxidant, antiatherogenic, antithrombotic effects. Epidemiological vitro/in vivo evidence antioxidant effects supports the cardioprotective function dietary flavonoids. Further, inhibition LDL oxidation platelet aggregation following regular consumption food containing moderate wine might protect against atherosclerosis thrombosis. One study suggests that daily intake 100 mg through may reduce risk developing morbidity mortality coronary heart disease (CHD) by approximately 10%. This review summarizes with sources implications CVDs including various redox-active (molecular) mechanisms Pharmacokinetic (oral bioavailability, drug metabolism), toxicological, therapeutic aspects also addressed herein future directions for discovery development useful candidates/therapeutic molecules.

Language: Английский

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