Oxidative stress, the blood–brain barrier and neurodegenerative diseases: The critical beneficial role of dietary antioxidants

Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 13(10), P. 3988 - 4024

Published: July 16, 2023

In recent years, growing awareness of the role oxidative stress in brain health has prompted antioxidants, especially dietary to receive attention as possible treatments strategies for patients with neurodegenerative diseases (NDs). The most widely studied antioxidants include active substances such vitamins, carotenoids, flavonoids and polyphenols. Dietary are found usually consumed foods fresh fruits, vegetables, nuts oils gaining popularity due recently their potential preventive protective agents against NDs, well abundant natural sources, generally non-toxic nature, ease long-term consumption. This review article examines development explores ‘two-sidedness’ blood–brain barrier (BBB) a nervous system an impeding use drug medicinal products and/or supplements prevention therapy reviews BBB permeability common suplements efficacy treatment NDs. Finally, current challenges future directions NDs using discussed, useful information on is provided.

Language: Английский

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Efficient Data-Driven Machine Learning Models for Cardiovascular Diseases Risk Prediction

Sensors, Journal Year: 2023, Volume and Issue: 23(3), P. 1161 - 1161

Published: Jan. 19, 2023

Cardiovascular diseases (CVDs) are now the leading cause of death, as quality life and human habits have changed significantly. CVDs accompanied by various complications, including all pathological changes involving heart and/or blood vessels. The list includes hypertension, coronary disease, failure, angina, myocardial infarction stroke. Hence, prevention early diagnosis could limit onset or progression disease. Nowadays, machine learning (ML) techniques gained a significant role in disease prediction an essential tool medicine. In this study, supervised ML-based methodology is presented through which we aim to design efficient models for CVD manifestation, highlighting SMOTE technique's superiority. Detailed analysis understanding risk factors shown explore their importance contribution prediction. These fed input features plethora ML models, trained tested identify most appropriate our objective under binary classification problem with uniform class probability distribution. Various were evaluated after use non-use Synthetic Minority Oversampling Technique (SMOTE), comparing them terms Accuracy, Recall, Precision Area Under Curve (AUC). experiment results showed that Stacking ensemble model 10-fold cross-validation prevailed over other ones achieving Accuracy 87.8%, Recall 88.3%, 88% AUC equal 98.2%.

Language: Английский

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Pomegranate Peel Phytochemistry, Pharmacological Properties, Methods of Extraction, and Its Application: A Comprehensive Review

ACS Omega, Journal Year: 2023, Volume and Issue: 8(39), P. 35452 - 35469

Published: Sept. 19, 2023

Pomegranate peel, derived from the processing of Punica granatum L. (pomegranate), has traditionally been considered agricultural waste. However, recent studies have revealed its potential as a rich source bioactive compounds with diverse pharmacological effects. peel is reservoir antioxidants, polyphenols, dietary fiber, and vitamins, which contribute to remarkable bioactivity. Studies demonstrated anti-inflammatory, cardioprotective, wound healing, anticancer, antimicrobial properties pomegranate owing presence phytochemicals, such gallic acid, ellagic punicalagin. The extraction requires careful selection techniques maximize yield quality. Green methods, including pressurized liquid (PLE), ultrasound-assisted (UAE), microwave-assisted (MAE), enzyme-assisted (EAE), offer efficient sustainable alternatives traditional methods. Furthermore, utilized in food industry, where it can significantly enhance nutritional value, organoleptic characteristics, shelf life products. be used develop innovative functional foods, nutraceuticals, other value-added products, providing new opportunities for pharmaceutical, cosmetic, industries.

Language: Английский

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A critical review on quercetin bioflavonoid and its derivatives: Scope, synthesis, and biological applications with future prospects

Arabian Journal of Chemistry, Journal Year: 2023, Volume and Issue: 16(8), P. 104881 - 104881

Published: April 11, 2023

Lifestyle is an important factor in health, and researchers are trying to see the adverse effect on human health of a change lifestyle. Many people follow unhealthy lifestyles, which affect physical mental health. Millions suffer from various problems like cardiovascular disease, overweight, malnutrition, hypertension, stress, violence, etc. There many medicines that can cure these diseases, but they have side effects. When man consumes green leaves vegetables his diet, chances reducing risk any disease increase. Every plant has primary secondary metabolites. Flavonoid metabolite found plants plays role survival by performing physiological activities being able withstand effects environment. Quercetin one such bioflavonoid plants, onions, citrus fruits, parsley, It comes under category flavone, with five hydroxy groups chromen-4-one skeletal structure. applications, include anti-cancer, anti-bacterial, anti-viral, anti-inflammatory, anti-diabetic, However, use quercetin limited due its poor bioavailability, aqueous solubility, lower stability gastrointestinal tract, first-pass effect. To enhance application quercetin, derivatives metal complex required water soluble, helps them reach target site without provides stability. This review divided into three main sections: The first section explains about flavonoids their types; second methods synthesis, derivatives, complex; last represents complete applications drawbacks how overcome or deal drawbacks.

Language: Английский

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Nutritional components, phytochemical compositions, biological properties, and potential food applications of ginger (Zingiber officinale): A comprehensive review

Journal of Food Composition and Analysis, Journal Year: 2024, Volume and Issue: 128, P. 106057 - 106057

Published: Feb. 5, 2024

Language: Английский

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