Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(3), P. 315 - 315
Published: Feb. 28, 2024
Cancer
continues
to
pose
one
of
the
most
critical
challenges
in
global
healthcare.
Despite
wide
array
existing
cancer
drugs,
primary
obstacle
remains
selectively
targeting
and
eliminating
cells
while
minimizing
damage
healthy
ones,
thereby
reducing
treatment
side
effects.
The
revolutionary
approach
utilizing
nanomaterials
for
delivering
therapeutic
agents
has
significantly
enhanced
efficacy
safety
chemotherapeutic
drugs.
This
crucial
shift
is
attributed
unique
properties
nanomaterials,
enabling
nanocarriers
transport
tumor
sites
both
passive
active
modes,
drug
elimination
from
delivery
systems.
Furthermore,
these
can
be
designed
respond
internal
or
external
stimuli,
thus
facilitating
controlled
release.
However,
production
nanomedications
therapy
encounters
various
that
impede
progress
this
field.
review
aims
provide
a
comprehensive
overview
current
state
nanomedication
treatment.
It
explores
variety
focusing
on
their
are
overcoming
limitations
conventional
chemotherapy.
Additionally,
delves
into
functionalities
nanocarriers,
highlighting
significant
impact
evolution
nanomedicine.
also
critically
assesses
recent
advancements
systems,
covering
range
innovative
methodologies.
Finally,
succinctly
addresses
encountered
developing
nanomedications,
offering
insightful
perspectives
guide
future
research
Molecules,
Journal Year:
2020,
Volume and Issue:
25(16), P. 3731 - 3731
Published: Aug. 15, 2020
Polymeric
nanoparticles
(NPs)
are
particles
within
the
size
range
from
1
to
1000
nm
and
can
be
loaded
with
active
compounds
entrapped
or
surface-adsorbed
onto
polymeric
core.
The
term
“nanoparticle”
stands
for
both
nanocapsules
nanospheres,
which
distinguished
by
morphological
structure.
NPs
have
shown
great
potential
targeted
delivery
of
drugs
treatment
several
diseases.
In
this
review,
we
discuss
most
commonly
used
methods
production
characterization
NPs,
association
efficiency
compound
core,
in
vitro
release
mechanisms.
As
safety
is
a
high
priority,
also
toxicology
ecotoxicology
humans
environment.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(3), P. 1851 - 1851
Published: Feb. 6, 2022
Neurodegenerative
disorders
are
primarily
characterized
by
neuron
loss.
The
most
common
neurodegenerative
include
Alzheimer’s
and
Parkinson’s
disease.
Although
there
several
medicines
currently
approved
for
managing
disorders,
a
large
majority
of
them
only
help
with
associated
symptoms.
This
lack
pathogenesis-targeting
therapies
is
due
to
the
restrictive
effects
blood–brain
barrier
(BBB),
which
keeps
close
99%
all
“foreign
substances”
out
brain.
Since
their
discovery,
nanoparticles
have
been
successfully
used
targeted
delivery
into
many
organs,
including
review
briefly
describes
pathophysiology
Alzheimer’s,
disease,
amyotrophic
lateral
sclerosis,
current
management
approaches.
We
then
highlight
major
challenges
brain-drug
delivery,
followed
role
nanotherapeutics
diagnosis
treatment
various
neurological
disorders.
Toxics,
Journal Year:
2021,
Volume and Issue:
9(6), P. 131 - 131
Published: June 4, 2021
Nanopesticides
are
nanostructures
with
two
to
three
dimensions
between
1
200
nm,
used
carry
agrochemical
ingredients
(AcI).
Because
of
their
unique
properties,
the
loading
AcI
into
nanoparticles
offers
benefits
when
compared
free
pesticides.
However,
fast
development
new
engineered
for
pests'
control,
a
type
environmental
waste
is
being
produced.
This
paper
describes
nanopesticides
sources,
harmful
and
health
effects
arising
from
pesticide
exposure.
The
potential
ameliorative
impact
on
agricultural
productivity
ecosystem
challenges
extensively
discussed.
Strategies
controlled
release
stimuli-responsive
systems
slow,
sustained,
targeted
genetic
material
delivery
reported.
Special
attention
different
source,
behavior
in
crop
setting,
most
recent
advancements
representative
research
experimental
results
revised.
review
also
addresses
some
issues
concerns
developing,
formulating
toxicity
products
environmentally
friendly
sustainable
agriculture.
Nanomaterials,
Journal Year:
2021,
Volume and Issue:
11(12), P. 3204 - 3204
Published: Nov. 26, 2021
Since
ancient
times,
silver
has
been
known
for
its
pronounced
bactericidal,
antiviral
and
fungicidal
properties.
Currently,
nanoparticles
of
this
metal
are
widely
used
in
the
food,
light
pharmaceutical
industries,
as
well
medicine.
Silver
any
form
can
have
a
toxic
effect
not
only
on
pathogens,
but
also
healthy
cells.
The
biological
activity
bioavailability
preparations
depend
degree
their
solubility
water.
In
addition,
maximum
permissible
concentration
soluble
forms
is
an
order
magnitude
lower
than
that
insoluble
forms.
This
makes
with
hydrophilic
coating
stable
colloidal
solutions
aqueous
media
potentially
unsafe
objects.
work,
we
studied
kinetics
accumulation
average
size
34
±
5
nm
stabilized
polyvinylpyrrolidone
organs
laboratory
C57Bl/6
mice.
administration
was
carried
out
orally
30,
60,
120
180
days
at
dose
50
µg/day/animal.
All
mice
developed
gained
weight
normally
during
experiment.
No
adverse
effects
were
observed.
Determination
content
tissues
mammals
accomplished
by
neutron
activation
analysis.
masses
concentrations
brain
different
sections
(hippocampus,
cerebellum,
cortex
remnants),
lungs,
testes,
liver,
blood,
kidneys,
spleen
heart,
determined.
injection
times
which
curves
reached
saturation
established.
An
extremely
high
testes
shown
administration,
significant
lungs
all
parts
except
significant,
trend
similar
to
whole
brain.
Molecules,
Journal Year:
2020,
Volume and Issue:
25(20), P. 4781 - 4781
Published: Oct. 18, 2020
Solid
lipid
nanoparticles
(SLNs)
and
nanostructured
carriers
(NLCs)
have
emerged
as
potential
drug
delivery
systems
for
various
applications
that
are
produced
from
physiological,
biodegradable,
biocompatible
lipids.
The
methods
used
to
produce
SLNs
NLCs
been
well
investigated
reviewed,
but
solvent
injection
method
provides
an
alternative
means
of
preparing
these
carriers.
advantages
include
a
fast
production
process,
easiness
handling,
applicability
in
many
laboratories
without
requirement
complicated
instruments.
effects
formulations
process
parameters
this
on
the
characteristics
several
studies.
This
review
describes
currently
prepare
with
focus
method.
We
summarize
recent
development
using
technique.
In
addition,
discussed.
Polymers,
Journal Year:
2022,
Volume and Issue:
14(4), P. 662 - 662
Published: Feb. 9, 2022
By
2050,
population
growth
and
climate
change
will
lead
to
increased
demand
for
food
water.
Nanoparticles
(NPs),
an
advanced
technology,
can
be
applied
many
areas
of
agriculture,
including
crop
protection
enhancement,
build
sustainable
agricultural
production.
Ionic
gelation
method
is
a
synthesis
microparticles
or
NPs,
based
on
electrostatic
interaction
between
opposite
charge
types
that
contains
at
least
one
polymer
under
mechanical
stirring
conditions.
which
are
commonly
chitosan
(CS),
have
been
fields,
nanopesticides,
nanofertilizers,
nanoherbicides.
The
CS-NP
CS-NPs-loaded
active
ingredients
(Cu,
saponin,
harpin,
Zn,
hexaconazole,
salicylic
acid
(SA),
NPK,
thiamine,
silicon,
silver
(Ag))
effective
in
controlling
plant
diseases
enhancing
growth,
depending
the
concentration
application
by
direct
indirect
mechanisms,
attracted
much
attention
last
five
years.
Many
crops
evaluated
vivo
greenhouse
conditions
but
only
maize
(CS-NP-loaded
Cu,
SA,
silicon)
soybean
Cu)
were
tested
manage
post
flowering
stalk
rot,
Curvularia
leaf
spot,
bacterial
pustule
disease
field
condition.
Since
2019,
eight
studies
performed
shown
interest
CS-NPs
synthesized
ionic
method.
In
this
review,
we
summarized
current
state
research
provided
forward-looking
view
use
management.
Bioactive Materials,
Journal Year:
2021,
Volume and Issue:
6(11), P. 3904 - 3923
Published: April 16, 2021
Natural
hydrogels
are
one
of
the
most
promising
biomaterials
for
tissue
engineering
applications,
due
to
their
biocompatibility,
biodegradability,
and
extracellular
matrix
mimicking
ability.
To
surpass
limitations
conventional
fabrication
techniques
recapitulate
complex
architecture
native
structure,
natural
being
constructed
using
novel
biofabrication
strategies,
such
as
textile
three-dimensional
bioprinting.
These
innovative
play
an
enormous
role
in
development
advanced
scaffolds
various
applications.
The
progress,
advantages,
shortcomings
emerging
highlighted
this
review.
Additionally,
applications
biofabricated
cardiac,
neural,
bone
discussed
well.
Advanced Science,
Journal Year:
2021,
Volume and Issue:
9(2)
Published: Nov. 10, 2021
Abstract
Plants
have
complex
internal
signaling
pathways
to
quickly
adjust
environmental
changes
and
harvest
energy
from
the
environment.
Facing
growing
population,
there
is
an
urgent
need
for
plant
transformation
precise
monitoring
of
growth
improve
crop
yields.
Nanotechnology,
interdisciplinary
research
field,
has
recently
been
boosting
yields
meeting
global
needs.
In
this
context,
a
new
“plant
nanoscience,”
which
describes
interaction
between
plants
nanotechnology,
emerges
as
times
require.
Nanosensors,
nanofertilizers,
nanopesticides,
nano‐plant
genetic
engineering
are
great
help
in
increasing
Nanogenerators
helping
develop
potential
field
harvesting.
Furthermore,
uptake
internalization
nanomaterials
possible
effects
also
worthy
attention.
review,
forward‐looking
perspective
on
nanoscience
presented
feasible
solutions
future
food
shortages
crises
provided.
Applied Sciences,
Journal Year:
2022,
Volume and Issue:
12(15), P. 7865 - 7865
Published: Aug. 5, 2022
This
review
summarizes
the
current
knowledge
on
and
future
applications
of
carbon
nanoparticles
in
medicine.
The
nanoparticle
family
has
a
large
number
representatives
with
unique
physicochemical
properties
that
make
them
good
candidates
for
use
clinical
best-known
(and
most
researched)
include
graphene,
graphene
oxide,
nanotubes.
main
direction
involves
medical
diagnostics,
which
includes
bioimaging
detection
chemicals
or
metabolites
present
body.
Since
question
toxicity
not
been
fully
answered,
fields
therapeutics
(drug
delivery),
regenerative
medicine
(cell
scaffolding,
tissue
engineering),
vaccine
production
is
still
under
research
many
vivo
studies
are
ongoing.
These
preclinical
suggest
have
great
potential
diagnosis
treatment;
results
show
used
do
significant
toxic
effects;
however,
caution
needed
before
introduced
into
routine
practice.
