Oxidative Stress in Autism Spectrum Disorder—Current Progress of Mechanisms and Biomarkers

Frontiers in Psychiatry, Journal Year: 2022, Volume and Issue: 13

Published: March 1, 2022

Autism spectrum disorder (ASD) is a type of neurodevelopmental that has been diagnosed in an increasing number children around the world. Existing data suggest early diagnosis and intervention can improve ASD outcomes. However, causes remain complex unclear, there are currently no clinical biomarkers for autism disorder. More mechanisms have found with development advanced technology such as mass spectrometry. Many recent studies link between elevated oxidative stress, which may play role its development. caused by stress several ways, including protein post-translational changes (e.g., carbonylation), abnormal metabolism lipid peroxidation), toxic buildup [e.g., reactive oxygen species (ROS)]. To detect ASD, various developed employed. This article summarizes about stress. Potential identified this study could be used evaluation intervention, well to inform target pharmacological or nutritional treatment interventions.

Language: Английский

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International society of sports nutrition position stand: energy drinks and energy shots

Journal of the International Society of Sports Nutrition, Journal Year: 2023, Volume and Issue: 20(1)

Published: March 2, 2023

Position Statement: The

Language: Английский

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Antioxidants and Sports Performance

Nutrients, Journal Year: 2023, Volume and Issue: 15(10), P. 2371 - 2371

Published: May 18, 2023

The role of reactive oxygen species and antioxidant response in training adaptations sports performance has been a large issue investigated the last few years. present review aims to analyze performance. For this aim, production physical activities, effect on performance, relationship between adaptations, inflammation, microbiota, antioxidants recovery strategies use supplementations will be discussed. Finally, practical applications derived from information are (ROS) during activity greatly influences This concludes that ROS play critical processes adaptation induced by resistance through reduction inflammatory mediators oxidative stress, as well appropriate molecular signaling. Additionally, it established micronutrients an important counteracting free radicals, such species, which cause effects recovery, for using supplements, vitamin C, E, resveratrol, coenzyme Q10, selenium, curcumin enhance mental well-being.

Language: Английский

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Cellular ROS and Antioxidants: Physiological and Pathological Role

Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 602 - 602

Published: May 14, 2024

Reactive oxygen species (ROS) are highly reactive derivatives that include free radicals such as superoxide anion radical (O2•−) and hydroxyl (HO•), well non-radical molecules hydrogen peroxide (H2O2), peroxynitrite (ONOO−), hypochlorous acid (HOCl) [...]

Language: Английский

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Association between composite dietary antioxidant index and handgrip strength in American adults: Data from National Health and Nutrition Examination Survey (NHANES, 2011-2014)

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: March 31, 2023

The Composite Dietary Antioxidant Index (CDAI), a composite score of multiple dietary antioxidants (including vitamin A, C, and E, selenium, zinc, carotenoids), represents an individual's comprehensive antioxidant intake profile. CDAI was developed based on its combined effect pro-inflammatory markers Tumor Necrosis Factor-α (TNF-α) anti-inflammatory effects Interleukin-1β (IL-1β), which are associated with many health outcomes, including depression, all-cause mortality, colorectal cancer, etc. Handgrip strength is used as simple measure muscle strength, not only it highly correlated overall but also serves diagnostic tool for adverse sarcopenia frailty syndromes.

Language: Английский

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The Impact of Oxidative Stress on Male Reproductive Function: Exploring the Role of Antioxidant Supplementation

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: July 27, 2023

Male reproductive function is highly susceptible to oxidative stress, which arises from an imbalance between reactive oxygen species (ROS) production and antioxidant defense mechanisms. Oxidative stress can significantly impair sperm quality, including count, motility, morphology, DNA integrity, leading male infertility. Antioxidants play a crucial role in maintaining health by neutralizing ROS protecting cells damage. This review article explores the impact of on investigates potential benefits supplementation mitigating its detrimental effects. A comprehensive literature search was conducted gather relevant studies examining effects fertility outcomes supplementation. The findings reveal that improve some individuals. However, conflicting research limitations study design highlight need for further investigation. Factors such as individual variations, underlying causes infertility, dosage, duration should be carefully considered. Lifestyle modifications, healthy diet exercise, are reducing optimizing health. provides valuable insights into complex relationship function, emphasizing supportive strategy. Further warranted establish optimal protocols, identify specific subgroups may benefit most, explore advancements therapies outcomes.

Language: Английский

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Role of vitamins A, C, D, E in cancer prevention and therapy: therapeutic potentials and mechanisms of action

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 10

Published: Jan. 11, 2024

Cancer, a leading global cause of mortality, arises from intricate interactions between genetic and environmental factors, fueling uncontrolled cell growth. Amidst existing treatment limitations, vitamins have emerged as promising candidates for cancer prevention treatment. This review focuses on Vitamins A, C, E, D because their protective activity against various types cancer. They are essential human metabolic coenzymes. Through critical exploration preclinical clinical studies via PubMed Google Scholar, the impact these therapy was analyzed, unraveling complicated mechanisms action. Interestingly, immune function, antioxidant defense, inflammation, epigenetic regulation, potentially enhancing outcomes by influencing behavior countering stress DNA damage. Encouraging trial results been observed; however, further well-controlled imperative to validate effectiveness, determine optimal dosages, formulate comprehensive strategies. Personalized supplementation strategies, informed medical expertise, pivotal in both contexts. Nevertheless, conclusive evidence regarding efficacy is still pending, urging research this compelling area study.

Language: Английский

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Benefits of a plant-based diet and considerations for the athlete

European Journal of Applied Physiology, Journal Year: 2022, Volume and Issue: 122(5), P. 1163 - 1178

Published: Feb. 12, 2022

Language: Английский

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Antioxidant and Anti-Inflammatory Compounds from Edible Plants with Anti-Cancer Activity and Their Potential Use as Drugs

Molecules, Journal Year: 2023, Volume and Issue: 28(3), P. 1488 - 1488

Published: Feb. 3, 2023

Food is our daily companion, performing numerous beneficial functions for bodies. Many of them can help to alleviate or prevent ailments and diseases. In this review, an extensive bibliographic search conducted in various databases update information on unprocessed foods with anti-inflammatory antioxidant properties that aid treating diseases such as cancer. The current state knowledge inflammatory processes involving some interleukins tumor necrosis factor-alpha (TNF-α) reviewed. As well foods, which may reduce inflammation oxidative stress, both are important factors cancer development. studies still needed take full advantage the food products we use daily.

Language: Английский

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Potential harms of supplementation with high doses of antioxidants in athletes

Journal of Exercise Science & Fitness, Journal Year: 2022, Volume and Issue: 20(4), P. 269 - 275

Published: June 11, 2022

Vigorous exercise generates large amounts of reactive oxygen species (ROS) as a result the consumption volumes O2 in athletes, causing some athletes to consume antioxidants erroneous belief that this will counteract damaging effects ROS. There is currently no convincing evidence support benefits antioxidant supplementation acute physical and training. On contrary, exogenous prevent physiological functions free radicals are needed for cell signaling, higher dosages hamper or performance-enhancing health-promoting training adaptation such mitochondrial biogenesis, skeletal cardiac muscle hypertrophy, improved insulin sensitivity. However, there remains perception can counterbalance oxidative stress benefit performance athletes. It likely negative high doses exceed their potential benefits. We discuss proposed pathways side

Language: Английский

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