Exploring environmental exposomes and the gut-brain nexus: Unveiling the impact of pesticide exposure

Environmental Research, Journal Year: 2024, Volume and Issue: 250, P. 118441 - 118441

Published: Feb. 11, 2024

Language: Английский

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Gut Microbiota as a Potential Player in Mn-Induced Neurotoxicity

Biomolecules, Journal Year: 2021, Volume and Issue: 11(9), P. 1292 - 1292

Published: Aug. 31, 2021

Manganese (Mn) is an essential metal, which at high exposures causes neurotoxic effects and neurodegeneration. The of Mn are mediated by neuroinflammation, oxidative endoplasmic reticulum stress, mitochondrial dysfunction, other mechanisms. Recent findings have demonstrated the potential impact overexposure on gut microbiota dysbiosis, known to contribute neurodegeneration via secretion neuroactive proinflammatory metabolites. Therefore, in this review, we discuss existing data exposure biodiversity, bacterial metabolite production, wall permeability regulating systemic levels. that may affect biodiversity altering abundance Shiegella, Ruminococcus, Dorea, Fusicatenibacter, Roseburia, Parabacteroides, Bacteroidetes, Firmicutes, Ruminococcaceae, Streptococcaceae, phyla. A Mn-induced increase Bacteroidetes a reduced Firmicutes/Bacteroidetes ratio lipopolysaccharide Moreover, addition increased (LPS) levels, capable potentiating LPS neurotoxicity. Due metabolic activity intestinal microflora, perturbations result significant alteration metabolome has least partially mediate biological overexposure. At same time, recent study healthy microbiome transplantation alleviates neurotoxicity, indicative role microflora cascade Mn-mediated High doses cause enterocyte toxicity integrity through disruption tight junctions. resulting further promotes translocation metabolites blood flow, ultimately gaining access brain leading neuroinflammation neurotransmitter imbalance. lead us hypothesize should be considered as target toxicity, although more detailed studies required characterize interplay between gut, well its pathogenesis diseases.

Language: Английский

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Impact of occupational pesticide exposure on the human gut microbiome

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 10, 2023

The rising use of pesticides in modern agriculture has led to a shift disease burden which exposure these chemicals plays an increasingly important role. human gut microbiome, is partially responsible for the biotransformation xenobiotics, also known promote environmental pollutants. Understanding effects occupational pesticide on microbiome can thus provide valuable insights into mechanisms underlying impact health. Here we investigate composition 7198 participants from Dutch Microbiome Project Lifelines Study. We used job-exposure matrices combination with codes retrieve categorical and cumulative estimates exposures general pesticides, herbicides, insecticides fungicides. Approximately 4% our cohort was occupationally exposed at least one class predominant multiple classes. Most reported long-term employment, suggesting profile exposure. demonstrate that contact insecticides, fungicides "all pesticides" consistently associated changes showing significant associations decreased alpha diversity differing beta diversity. report abundance 39 different bacterial taxa upon classes included this study. Together, extent statistically relevant between microbial findings highlights compounds microbiome.

Language: Английский

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Stochastic modelling of pesticide transport to drinking water sources via runoff and resulting human health risk assessment

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 918, P. 170589 - 170589

Published: Feb. 1, 2024

A modelling framework was developed to facilitate a probabilistic assessment of health risks posed by pesticide exposure via drinking water due runoff, with the inclusion influential site conditions and in-stream processes. Monte-Carlo based approach utilised account for inherent variability in population properties, as well climatic conditions. The presented this study an ability integrate different data sources adapt model various scenarios locations meet users' needs. results from can be used farm advisors catchment managers identify lower risk pesticides use given soil implement mitigation measures protect resources. Pesticide concentrations surface water, their regulatory threshold exceedances, were simulated fifteen Irish case study. predicted then quantify level adults children. analysis indicated that herbicides triclopyr MCPA occur greatest while mecoprop associated highest potential risks. found modelled little human under current application patterns Ireland using international acceptable intake values. sensitivity conducted examined impact seasonal conditions, timing application, instream processes, have on transport water.

Language: Английский

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Exploring the gut microbiome and head and neck cancer interplay

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 263, P. 155603 - 155603

Published: Sept. 28, 2024

Language: Английский

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