Associations between neonicotinoids and inflammation in US adults using hematological indices: NHANES 2015–2016 DOI Creative Commons

Amruta M. Godbole,

Aimin Chen, Ann M. Vuong

et al.

Environmental Epidemiology, Journal Year: 2024, Volume and Issue: 9(1), P. e358 - e358

Published: Dec. 24, 2024

Background: Toxicological studies suggest neonicotinoids increase oxidative stress and inflammation, but few epidemiological have explored these effects. Methods: National Health Nutrition Examination Survey (NHANES) 2015–2016 data were used to estimate associations between neonicotinoid exposure inflammatory markers, including the C-reactive protein-to-lymphocyte count ratio (CLR), monocyte-to-high-density lipoprotein (MHR), monocyte-to-lymphocyte (MLR), neutrophil-to-lymphocyte (NLR), derived NLR (dNLR), lymphocyte-to-monocyte ratio, platelet-to-lymphocyte (PLR), systemic immune-inflammation index (SII) using linear multinomial logistic regression models. Sex was evaluated as a potential modifier. Results: Detection of any parent ( β = −0.62, 95% confidence interval [CI] −0.98, −0.26) imidacloprid −0.48, CI −0.87, −0.10) associated with decreased CLR. Clothianidin linked reduced MLR −0.04, −0.07, −0.02), increased 0.52, 0.27, 0.77). Higher dNLR 0.85; 0.26, 1.43) noted detection metabolite. Moderately high PLR observed metabolite (relative risk [RRR] 1.63, 1.27, 2.09) or 5-hydroxy-imidacloprid (RRR 2.19, 1.40, 3.41). Sex-modified analyses showed positive in males inverse females for MHR P int 0.099, clothianidin), 0.026, SII 0.056, neonicotinoid; 0.002, while opposite pattern CLR 0.073, neonicotinoid) 0.084, clothianidin). Conclusion: Neonicotinoids may be changes, sexual dimorphism. Further are required explore findings.

Language: Английский

Neonicotinoid Insecticides and Their Metabolites Can Pass through the Human Placenta Unimpeded DOI

Henglin Zhang,

Xueyuan Bai,

Tao Zhang

et al.

Environmental Science & Technology, Journal Year: 2022, Volume and Issue: 56(23), P. 17143 - 17152

Published: Nov. 28, 2022

Studies on neonicotinoid (NEO) exposure in pregnant women and fetuses are scarce, transplacental transfer of these insecticides is unknown. In this study, parent NEOs (p-NEOs) their metabolites (m-NEOs) were determined 95 paired maternal (MS) cord serum (CS) samples collected southern China. Imidacloprid was the predominant p-NEO both CS MS samples, found at median concentrations 1.84 0.79 ng/mL, respectively, whereas N-desmethyl-acetamiprid most abundant m-NEO (median: 0.083 ng/mL) (0.13 ng/mL). The efficiencies (TTEs) p-NEOs m-NEOs high, ranging from 0.81 (thiamethoxam, THM) to 1.61 (olefin-imidacloprid, of-IMI), indicating efficient placental insecticides. Moreover, transport appears be passive structure-dependent: cyanoamidine such as acetamiprid thiacloprid had higher TTE values than nitroguanidine NEOs, namely, clothianidin THM. Multilinear regression analysis revealed that several associated significantly with hematological parameters related hepatotoxicity renal toxicity. To our knowledge, first occurrence distribution maternal-fetal samples.

Language: Английский

Citations

54
Concentrations of neonicotinoid insecticides and their metabolites in multiple urine samples collected from pregnant women in Japan DOI
Neeranuch Suwannarin, Tomohiko Isobe, Yukiko Nishihama

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 240, P. 117506 - 117506

Published: Oct. 30, 2023

Language: Английский

Citations

8
Organophosphate insecticide exposure and respiratory symptoms among school children in Northern Thailand: Interaction by biomass burning, dampness and season DOI Creative Commons

Nathaporn Thongjan,

Tippawan Prapamontol, Chalerm Liwsrisakun

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 949, P. 175122 - 175122

Published: July 29, 2024

The aim was to study associations between dialkylphosphates (DAPs), organophosphate (OP) metabolites in urine, biomarkers of OP insecticide exposure, and respiratory symptoms among children upper northern Thailand. We recruited junior high school randomly selected schools four cities (N = 337), with repeated data collection wet dry seasons. Urine collected analyzed for six metabolites, creatinine adjustment. Total DAP expressed as sum DAPs. Data on by a standardized questionnaire. Associations were multiple logistic regression. Totally 11.3 % lived farm families. DAPs concentration higher season (p 0.002) but did not differ non-farm children. associated current wheeze 0.019), asthma attacks 0.012) breathlessness last 12 months 0.021). 0.042), stronger dimethylphosphate (DMPs) than diethylphosphate (DEPs). DMPs are produced certain pesticides. Biomass burning inside or outside the home, dampness mold at enhanced association total breathlessness. In conclusion, pesticide measured urinary DAPs, similar OPs especially DMP related pesticides, can increase asthmatic symptoms, season. Combined exposure smoke from biomass burning, mold, further prevalence There is need reduce Thai Since different pesticides be used seasons, studies health effects should done

Language: Английский

Citations

2
Associations between neonicotinoids metabolites and hematologic parameters among US adults in NHANES 2015–2016 DOI

Chunxiu Yang,

Jun Liang

Environmental Science and Pollution Research, Journal Year: 2022, Volume and Issue: 30(10), P. 26327 - 26337

Published: Nov. 11, 2022

Language: Английский

Citations

10
Associations between neonicotinoids and inflammation in US adults using hematological indices: NHANES 2015–2016 DOI Creative Commons

Amruta M. Godbole,

Aimin Chen, Ann M. Vuong

et al.

Environmental Epidemiology, Journal Year: 2024, Volume and Issue: 9(1), P. e358 - e358

Published: Dec. 24, 2024

Background: Toxicological studies suggest neonicotinoids increase oxidative stress and inflammation, but few epidemiological have explored these effects. Methods: National Health Nutrition Examination Survey (NHANES) 2015–2016 data were used to estimate associations between neonicotinoid exposure inflammatory markers, including the C-reactive protein-to-lymphocyte count ratio (CLR), monocyte-to-high-density lipoprotein (MHR), monocyte-to-lymphocyte (MLR), neutrophil-to-lymphocyte (NLR), derived NLR (dNLR), lymphocyte-to-monocyte ratio, platelet-to-lymphocyte (PLR), systemic immune-inflammation index (SII) using linear multinomial logistic regression models. Sex was evaluated as a potential modifier. Results: Detection of any parent ( β = −0.62, 95% confidence interval [CI] −0.98, −0.26) imidacloprid −0.48, CI −0.87, −0.10) associated with decreased CLR. Clothianidin linked reduced MLR −0.04, −0.07, −0.02), increased 0.52, 0.27, 0.77). Higher dNLR 0.85; 0.26, 1.43) noted detection metabolite. Moderately high PLR observed metabolite (relative risk [RRR] 1.63, 1.27, 2.09) or 5-hydroxy-imidacloprid (RRR 2.19, 1.40, 3.41). Sex-modified analyses showed positive in males inverse females for MHR P int 0.099, clothianidin), 0.026, SII 0.056, neonicotinoid; 0.002, while opposite pattern CLR 0.073, neonicotinoid) 0.084, clothianidin). Conclusion: Neonicotinoids may be changes, sexual dimorphism. Further are required explore findings.

Language: Английский

Citations

0