N- Acetyl Cysteine Versus Hesperidin as a Prophylactic Agent for Lambda - Cyhalothrin Induced Hepatotoxicity in Adult Male Albino Rats: Histological and Immunohistochemical Study

The Egyptian Journal of Hospital Medicine, Journal Year: 2023, Volume and Issue: 90(1), P. 282 - 293

Published: Jan. 1, 2023

Introduction: Lambda Cyhalothrin (LCT) is greatly used to manage a wide variety of pests present in farming and home procedures.Aim: The current work was intended demonstrate structural functional alterations within the liver subsequent long-standing exposure LCT.Protective effect Hesperidin N-acetylcysteine also investigated.Material methods: 40 adult male albino rats were this experiment, they split into four equal groups: control, LCT group, received at dose 61.2mg/kg b. wt. per day by oral gavage for 28 days.LCT + given same with simultaneous dosage HSP 100mg/kg wt., N-Acetyl cysteine group which as previous 2 groups administration N-acetyl 150 mg/kg wt.The underwent number biochemical, histological, immunohistochemical analysis.Results: induced oxidative stress leads damage (increases MDA / decreases GSH).LCT caused degeneration hepatocytes increases inflammatory cells, followed rise markers (AST ALT).While concurrent during period preserved architecture liver, prevents its damage, reduced normalized function tests.Conclusion: Administration N -Acetyl insecticide has protective on more than Hesperidin.

Language: Английский

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Solid Lipid Nanoparticles Encapsulating Naturally Derived Boschniakine Mitigates Induced Diabetic Nephropathy

Precision Nanomedicine, Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 28, 2023

Boschniakine, a bioalkaloid isolated from the Tecoma stans plant, has been reported to be traditionally utilized for management of diabetes in model systems through multiple biochemical mechanisms. Studies on Boschniakine are sparse, also, taking into consideration that poor absorption, rapid metabolic rate, and systemic elimination could limit bioalkaloids’ pharmacological efficacy. To recognize such limitations, we propose use highly bioavailable Boschniakine-Solid Lipid Nanoparticles (Bos-SLNPs). This study examined potential molecular mechanisms underlying anti-diabetic effects Bos-SLNP. Bos-SLNP (25 50 mg/kg) was evaluated 30 days its antidiabetic activity streptozotocin-induced Type 1 2 diabetic rats. In addition, RT-PCR technique used determine messenger-RNA expression Interleukin-1, Interleukin-6, Tumor Necrosis Factor-alpha renal tissue. haematoxylin eosin staining Western blotting were find differences nuclear factor erythroid 2-related 2/heme oxygenase/Nuclear Factor-κB signaling pathway how proteins expressed. Bos-SLNPs treatment resulted an increase factors heme oxygenase-1 decrease Nuclear factor-B. because have protective mechanism, which comes their anti-inflammatory anti-oxidant properties. exhibited effect against nephropathy rats induced with streptozocin, possibly via / oxygenase 1/ B.

Language: Английский

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Ameliorative impact of coenzyme Q10 supplementation on deltamethrin-induced hepatic damage in broiler chickens

Benha Veterinary Medical Journal, Journal Year: 2022, Volume and Issue: 42(1), P. 25 - 32

Published: April 1, 2022

Deltamethrin (DM) is a synthetic insecticide that commonly used in agriculture and veterinary medicine.Furthermore, animal human studies have shown DM has negative impact on the liver.This study was carried out to evaluate protective effect of Coenzyme Q10 (CoQ10) supplementation against hepatotoxicity broiler chickens.Sixty chicks were divided into 4 groups.First group (basal diet), second (40 mg CoQ10 /kg third (300 DM/kg fourth diet) CoQ10mg/kg diet).The treatment administered final three groups for 35 days.DM declined body weight (BW), gain (BWG), increased feed conversion rate (FCR).Significant increases aspartate aminotransferase (AST), alanine (ALT), malondialdehyde (MDA), with significant drop levels reduced glutathione (GSH) superoxide dismutase (SOD) also recorded this group.Caspase-3 B cell lymphoma 2 (BCl2) substantially upregulated by liver tissues.In addition, alterations histopathology as severe congestion mononuclear inflammatory cellular infiltration hepatic parenchyma vacuolation cells examined chickens intoxicated DM.Concurrent resulted improvement estimated parameters when compared group.Because its effects DMinduced broilers, dietary recommended.

Language: Английский

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Ameliorative effect of coenzyme Q10 against deltamethrin-induced renal toxicity in broiler chickens

Benha Veterinary Medical Journal, Journal Year: 2022, Volume and Issue: 42(1), P. 17 - 24

Published: April 1, 2022

The ameliorating effect of Coenzyme Q10 (CoQ10) supplementation was evaluated on broiler chickens intoxicated with deltamethrin (DM) through serum biochemical analysis, antioxidant capacity, and pathological examination.Cobb chicks (60) aged 1 day were allocated into 4 experimental equal groups.For each group, three replicates 5 used.The first group (control) received only the basal diet, second CoQ10 (40 mg/kg diet), third DM (300 fourth both diet) diet).The period 35 days has been given to last 3 groups.DM intoxication associated significant increases in creatinine, urea, malondialdehyde (MDA), a drop levels reduced glutathione (GSH) superoxide dismutase (SOD).In addition, increased blood cholesterol, triacylglycerols, low-density lipoprotein (LDL), while lowered high-density (HDL).Caspase-3 B cell lymphoma 2 (BCl2) substantially unregulated by kidney tissues.The microscopic examination kidneys revealed congestion renal vessels necrosis lining epithelium tubules.Concurrent resulted notable improvement estimated parameters compared group.Dietary is therefore advised because its preventive properties against DM-induced toxicity broilers. Deltamethrin

Language: Английский

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CONTRAST INDUCED ACUTE KIDNEY INJURY IS NOT A SITUATION TO BE AFRAID OF

Wiadomości Lekarskie, Journal Year: 2022, Volume and Issue: 75(11), P. 2839 - 2842

Published: Jan. 1, 2022

Acute kidney injury (AKI), formerly called acute renal failure (ARF), is clinically manifested as a reversible increase in nitrogen waste products, measured by blood urea (BUN) and serum creatinine levels. Contrast induced (CIAKI) potentially fatal complication of angiographic procedures caused the use contrast media (CM). It third most prevalent cause hospital acquired damage, accounting for around up to 30% cases. nephropathy (CIN) defined greater than 25% or 0.5 mg/dl (44 μmol/l) (Scr) from baseline within 3 days. More sensitive indicators damage are sought, hence numerous tubular biomarkers being studied. Multiple risk factors may lead development CIN; these classified patient-related procedure-related. Treatment CIN Is primarily symptomatic consist firstly careful fluid electrolyte management, although dialysis be necessary some With available treatment options, prevention cornerstone management.

Language: Английский

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