Neuropsychiatric aspects of long COVID: A comprehensive review

Psychiatry and Clinical Neurosciences, Journal Year: 2022, Volume and Issue: 77(2), P. 84 - 93

Published: Nov. 17, 2022

Although some patients have persistent symptoms or develop new following coronavirus disease 2019 (COVID-19) infection, neuropsychiatric aspects of long COVID are not well known. This review summarizes and provides an update on the dimensions COVID. Its manifestations commonly include fatigue, cognitive impairment, sleep disorders, depression, anxiety, post-traumatic stress disorder. There no specific tests for COVID, but characteristic findings such as hypometabolism positron emission tomography been reported. The possible mechanisms inflammation, ischemic effects, direct viral invasion, social environmental changes. Some patient characteristics severity complications acute COVID-19 infection may be associated with increased risk symptoms. Long resolve spontaneously persist, depending type established treatments lacking, various psychological pharmacological attempted. Vaccination against plays a key role in prevention disease. With differences among SARS-CoV-2 variants, including omicron variant, likely to change future. Further studies clarifying effective warranted.

Language: Английский

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S1-Leitlinie Long-/Post-COVID

Pneumologie, Journal Year: 2022, Volume and Issue: 76(12), P. 855 - 907

Published: Dec. 1, 2022

The German Society of Pneumology initiated 2021 the AWMF S1 guideline Long COVID/Post-COVID. In a broad interdisciplinary approach, this was designed based on current state knowledge.The clinical recommendations describe COVID/Post-COVID symptoms, diagnostic approaches, and therapies.In addition to general consensus introduction, subject-specific approach taken summarize has an explicit practical claim will be developed adapted by author team increase in knowledge.Die Deutsche Gesellschaft für Pneumologie hat die S1-Leitlinie Long-/Post-COVID initiiert. einem breiten interdisziplinären Ansatz wurde diese basierend auf dem aktuellen Wissensstand gestaltet.Die klinische Empfehlung beschreibt Long- bzw. Post-COVID-Symptome, diagnostische Ansätze und Therapien.Neben der allgemeinen konsentierten Einführung ein fachspezifischer Zugang gewählt, den zusammenfasst.Die Leitlinie einen explizit praktischen Anspruch wird Wissenszugewinn vom Autorenteam weiterentwickelt adaptiert.

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Rehabilitation Interventions for Physical Capacity and Quality of Life in Adults With Post–COVID-19 Condition

JAMA Network Open, Journal Year: 2023, Volume and Issue: 6(9), P. e2333838 - e2333838

Published: Sept. 19, 2023

Importance Current rehabilitation guidelines for patients with post–COVID-19 condition (PCC) are primarily based on expert opinions and observational data, there is an urgent need evidence-based interventions to support PCC. Objective To synthesize the findings of existing studies that report physical capacity (including functional exercise capacity, muscle function, dyspnea, respiratory function) quality life outcomes following in Data Sources A systematic electronic search was performed from January 2020 until February 2023, MEDLINE, Scopus, CINAHL, Clinical Trials Registry. Key terms were used identify potentially relevant included long-covid , post-covid sequelae therapy activity randomized controlled trial . Study Selection This study clinical trials compared training exercise-based either placebo, usual care, waiting list, or control Extraction Synthesis followed Preferred Reporting Items Systematic Reviews Meta-Analyses. pairwise bayesian random-effects meta-analysis using vague prior distributions. Risk bias assessed Cochrane risk tool version 2, certainty evidence evaluated GRADE system by 2 independent researchers. Main Outcomes Measures The primary outcome measured at closest postintervention time point 6-minute walking test. Secondary fatigue, lower limb life. All defined a priori. Continuous reported as standardized mean differences (SMDs) 95% credible intervals (CrIs) binary summarized odds ratios CrIs. between-trial heterogeneity quantified between-study variance, τ Results Of 1834 identified records, 1193 screened, 14 (1244 patients; 45% female participants; median [IQR] age, 50 [47 56] years) analyses. Rehabilitation associated improvements (SMD, −0.56; CrI, −0.87 −0.22) moderate 7 (389 participants). These had 99% posterior probability superiority when current standard care. value (0.04; 0.00 0.60) indicated low statistical heterogeneity. However, significant uncertainty imprecision regarding experiencing exercise-induced adverse events (odds ratio, 1.68; 0.32 9.94). Conclusions Relevance this review suggest life, high improvement care; other outcomes. Given surrounding safety outcomes, additional enhanced monitoring necessary.

Language: Английский

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Long COVID and rehabilitation

Journal of the Formosan Medical Association, Journal Year: 2023, Volume and Issue: 123, P. S61 - S69

Published: April 13, 2023

Coronavirus disease 2019 (COVID-19) has caused tremendous morbidity and mortality worldwide. The large number of post-COVID survivors drawn attention to the management condition, known as long COVID. This review examines current knowledge COVID, regarding its epidemiology, mechanism, clinical presentations in both adults children. We also rehabilitation principles, modules, effects, share Taiwan's efforts provide a top-down, nationwide care framework for COVID patients. Dyspnea, chronic cough, fatigue are most commonly reported symptoms first 6 months after infection, but cognitive impairment psychological may persist beyond this time. Several possible mechanisms behind these were proposed, remained unconfirmed. These negatively impact individuals' function, activities, participation quality life. Rehabilitation is key element achieve functional improvement. Early should start with comprehensive evaluation identification red flags. Exercise-based therapy, an essential part can be conducted different including telerehabilitation. Post-exertional symptom exacerbation orthostatic hypotension carefully monitored during exercise. Randomized control trials sample size needed determine optimal timing, dosage, modules.

Language: Английский

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Post-COVID syndrome

Deutsches Ärzteblatt international, Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 10, 2023

As defined by the WHO, term post-COVID syndrome (PCS) embraces a group of symptoms that can occur following acute phase SARS-CoV-2 infection and as consequence thereof. PCS is found mainly in adults, less frequently children adolescents. It develop both patients who initially had only mild or none at all those severe course coronavirus disease 2019 (COVID-19).The data presented here were derived from systematic literature review.PCS occurs up to 15% unvaccinated adults infected with SARS-CoV-2. The prevalence has decreased most recent pandemic lower after vaccination. pathogenesis not yet been fully elucidated. Virustriggered inflammation, autoimmunity, endothelial damage (to blood vessels), persistence virus are thought be causative. Owing broad viral tropism, different organs involved vary. To date, there hardly any evidence-based recommendations for definitive diagnosis its treatment.The gaps our knowledge mean better documentation necessary compile on which early detection, diagnosis, treatment based. ensure best possible care PCS, regional centers networks embracing existing structures healthcare system sectors providers should set structured algorithms established. Given sometimes serious consequences affected, it seems advisable keep number infections low protective measures tailored prevailing situation.

Language: Английский

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Exercise Training in Post-COVID-19 Patients: The Need for a Multifactorial Protocol for a Multifactorial Pathophysiology

Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(8), P. 2228 - 2228

Published: April 15, 2022

The battle against COVID-19 has entered a new phase with Rehabilitation Centres being among the major players, because medical outcome of patients does not end control pulmonary inflammation marked by negative virology test, as many continue to suffer from long-COVID-19 syndrome. Exercise training is known be highly valuable in cardiac or lung disease, and it exerts beneficial effects on immune system inflammation. We therefore reviewed past recent papers about exercise training, considering multifactorial features characterizing post-COVID-19 patients’ clinical conditions. Consequently, we conceived proposal for patient protocol combination multiple recommended regimens. Specifically, built pre-evaluation taking advantage various programs already validated diseases that may share pathophysiological characteristics long-COVID-19.

Language: Английский

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Phenotyping Post-COVID Pain as a Nociceptive, Neuropathic, or Nociplastic Pain Condition

Biomedicines, Journal Year: 2022, Volume and Issue: 10(10), P. 2562 - 2562

Published: Oct. 13, 2022

Pain after an acute Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) condition (post-COVID pain) is becoming a new healthcare emergency. Precision medicine refers to evidence-based method of grouping patients based on their diagnostic/symptom presentation then tailoring specific treatments accordingly. Evidence suggests that post-COVID pain can be categorized as nociceptive (i.e., attributable the activation peripheral receptive terminals primary afferent neurons in response noxious chemical, mechanical, or thermal stimuli), neuropathic associated with lesion somatosensory nervous system limited “neuroanatomically plausible” distribution system), nociplastic arising from altered nociception despite no clear evidence actual threatened tissue damage causing nociceptors for pain), mixed type (when two phenotypes co-exist). Each these may require different treatment approach maximize effectiveness. Accordingly, ability classify into one would likely critical producing successful outcomes. The 2021 International Association Study (IASP) clinical criteria grading provide framework classifying within precision approach. Here we present data supporting possibility phenotypes, using IASP classification criteria, focus pain, which probably mechanism involved pain. Nociplastic usually comorbid symptomology (e.g., poor sleep quality, fatigue, cognitive–emotional disturbances, etc.) considered more difficult treat than other types, nuanced multimodal achieve better

Language: Английский

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Pulmonary Rehabilitation for People With Persistent Symptoms After COVID-19

CHEST Journal, Journal Year: 2024, Volume and Issue: 166(3), P. 461 - 471

Published: Jan. 19, 2024

Language: Английский

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Physical Activity in Long COVID: A Comparative Study of Exercise Rehabilitation Benefits in Patients with Long COVID, Coronary Artery Disease and Fibromyalgia

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(15), P. 6513 - 6513

Published: Aug. 3, 2023

Exercise in long COVID is poorly studied. Nevertheless, exerciserehabilitation could improve cardiorespiratory, muscular and autonomic functions. We aimed to investigate improvement physical performances of patients (n = 38) after a 4-week exercise rehabilitation program (3 sessions/week) compared two control groups composed coronary artery disease fibromyalgia 38), populations for whom benefits are well known. Efficacy training was assessed by cardiopulmonary test, handgrip force supine heart rate variability recording at rest before the program. Cardiorespiratory parameters were enhanced three (p < 0.001). No significant difference observed variables. Through this comparative study with groups, we confirm reinforce interest caring without post-exertional symptom exacerbation both strength endurance training, personalizing patient symptoms.

Language: Английский

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Systematic Review of Multi-Dimensional Vulnerabilities in the Himalayas

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(19), P. 12177 - 12177

Published: Sept. 26, 2022

The Himalayan region is a fragile high mountain landscape where the population experiences acute vulnerability within complex coupled human–natural system due to environmental, social, and economic linkages. lack of significant regional spatial knowledge multi-faceted vulnerabilities hinders any potential recommendations address these vulnerabilities. We systematically reviewed literature recommend mitigation interventions based on region’s socio-economic ecological research date. applied PRISMA (Preferred Reporting Items for Systematic Review Meta-Analysis) criteria search results from four comprehensive databases. For our assessment, we compiled final sample (n = 59) papers examine types, variation, assessment methodology, drivers change. Our study represented all countries, namely, India, Nepal, Pakistan, China, Bhutan. More than half studies were conducted in central region, quarter western Himalayas, few eastern Himalayas. review revealed that primary change climate change, land use/land cover, glacial lake formation. assessments primarily used social science methods as compared natural methods. While seldom assessed interventions, analysis identified fourteen recommendations. recommended mainly included policy livelihood improvement, adaptation measures. This emphasized sustainable development requires cross-sectoral manage existing resources mitigate confronting region.

Language: Английский

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