Diagnosis of complex breast cysts using X-ray pneumocystography and endoscopic mammocystoscopy DOI Creative Commons
O. A. Aksonov

Reproductive Endocrinology, Journal Year: 2022, Volume and Issue: 66, P. 98 - 103

Published: Aug. 10, 2022

Background. Complex cysts of the breast (CCB), in contrast to simple and complicated cysts, are characterized by a high (up 31.0%) oncological potential. Mammography ultrasound (US) as most common methods radiological diagnosis do not allow classify CCB on benign malignant, case cancer (BC) detected establishment its molecular genetic subtype.Objectives: analyze popularize own experience using endoscopic mammocystoscopy (EMCS) X-ray pneumocystography (RPCG) for biopsy navigation. Materials methods. The clinical anamnestic data, results radiological, pathomorphological studies 286 adult women with simple, were analyzed (n = 45, 134 142, respectively).Results. diagnostic navigation capabilities US limited frequent (18.1%) false-negative results, which caused atypical echosemiotics CCB. Trepan-biopsy under control becomes impossible when visualization disappears, often occurs during fine-needle aspiration liquid component. Technical difficulties arise imitating puncture needle linear hyperechoic structures induced Cooper’s ligaments, well positioning bulky, non-fixed gland. In terms specificity prognostic significance negative result, RPCG is slightly (5.6 4.7%, respectively) inferior certain situations it can be used assess likelihood BC, positive navigate stereotaxic сore biopsy. EMCS low-traumatic procedure that provides direct visual contact intracystic neoplasms, allows assessing probability BC conducting pinch biopsy.Conclusions. consistent combined use well-known author’s involvement US, according given algorithm ensures effective management at modern level.

Language: Английский

Differential risk of 23 site‐specific incident cancers and cancer‐related mortality among patients with metabolic dysfunction‐associated fatty liver disease: a population‐based cohort study with 9.7 million Korean subjects DOI Creative Commons
Goh Eun Chung, Su Jong Yu, Jeong‐Ju Yoo

et al.

Cancer Communications, Journal Year: 2023, Volume and Issue: 43(8), P. 863 - 876

Published: June 19, 2023

Although an association between metabolic dysfunction-associated fatty liver disease (MAFLD) and cardiovascular or overall mortality has been reported, it is unclear whether there MAFLD cancer incidence mortality. We aimed to investigate the differential risk of all- site-specific according subgroups categorized by additional etiologies disease.Using Korean National Health Insurance Service database, we stratified participants into three groups: (1) single-etiology (S-MAFLD) pure origin; (2) mixed-etiology (M-MAFLD) with etiological factor(s) (i.e., concomitant diseases and/or heavy alcohol consumption); (3) non-MAFLD. Hepatic steatosis fibrosis were defined using index BARD score, respectively. Cox proportional hazards regression was performed estimate events.Among 9,718,182 participants, prevalence S-MAFLD M-MAFLD 29.2% 6.7%, During median 8.3 years follow-up, 510,330 (5.3%) individuals newly diagnosed cancer, 122,774 (1.3%) cancer-related deaths occurred among entire cohort. Compared non-MAFLD group, all-cancer slightly higher patients in group (incidence, adjusted hazard ratio [aHR] = 1.03; 95% confidence interval [CI]: 1.02-1.04; mortality, aHR 1.06; CI: 1.04-1.08) highest 1.31; 1.29-1.32; 1.45; 1.42-1.48, respectively). The (BARD score ≥ 2) showed relative (aHR 1.38, CI 1.36-1.39), followed without 1.09, 1.06-1.11). Similar trends observed for mortality.MAFLD classification, applying other than origin, can be used identify a subgroup poor outcomes.

Language: Английский

Citations

11
The Adipokine Visfatin Modulates Cancer Stem Cell Properties in Triple-Negative Breast Cancer DOI Creative Commons

Yi‐Fen Chiang,

Ko‐Chieh Huang,

Y-H. Chen

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(2), P. 297 - 297

Published: Jan. 20, 2023

Obesity is a cancer progression risk factor; excessive adipocytes increase adipokine secretion. Visfatin, novel highly expressed in patients, related to breast risk. The modulation of nicotinamide adenine dinucleotide (NAD+) metabolism and the induction tumorigenic environment plays vital role progression. Among cell types, stem-like cells (CSCs) with self-renewal chemotherapy-resistance abilities could modulate tumor recurrence ability. In this study, we focused on visfatin's effect stemness-related properties using high-malignancy line MDA-MB-231 vitro vivo studies. Visfatin treatment significantly increased both sphere number diameter protein expression NANOG homeobox (NANOG), sex-determining region Y-box 2 (SOX2), octamer-binding transcription factor 4 (OCT4), as well SIRT1 levels. serum angiogenesis marker VEGF extracellular phosphoribosyl transferase (NAMPT, visfatin) were induced after visfatin treatment, increasing stemness environment, which reduced by inhibitor FK866. Our results demonstrate that visfatin-activated SIRT-SOX2 axis promotes triple-negative enriches microenvironment.

Language: Английский

Citations

4
Role of Incretins in Muscle Functionality, Metabolism, and Body Composition in Breast Cancer: A Metabolic Approach to Understanding This Pathology DOI Creative Commons
Brenda-Eugenia Martínez-Herrera, M Muñoz-Garcia, L. Ochoa

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(2), P. 280 - 280

Published: Jan. 25, 2024

A poorly studied issue in women with breast cancer is the role of incretins (GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1)) quantity quality muscle mass lean obese individuals. The current report aims to analyze patterns association incretin functionality body composition compared healthy (mammography BI-RADS I or II) elucidate whether GIP can be used estimate risk, conjunction overweight obesity, for cancer. We designed a case–control study diagnosis confirmed by biopsy different clinical stages (CS; n = 87) mastography II within last year (n 69). were grouped according index (BMI): (<25 kg/m2BS), (≥25–<30 (≥30 kg/m2BS). found that levels over 18 pg/mL associated risk OR 36.5 4.16, entire sample), particularly 8.8 6.5), coincidentally low indexes, showed an between cancer, defects, loss functionality.

Language: Английский

Citations

1
Phase Angle and Nutritional Status: The Impact on Survival and Health-Related Quality of Life in Locally Advanced Uterine Cervical Cancer DOI Open Access
F. Gonzalez-Barba, Luz-Ma-Adriana Balderas-Peña, Benjamín Trujillo‐Hernández

et al.

Healthcare, Journal Year: 2023, Volume and Issue: 11(2), P. 246 - 246

Published: Jan. 13, 2023

The phase angle, an indicator of muscle mass status and membrane cell integrity, has been associated with low survival, poorer clinical outcomes, worse quality life among cancer patients, but information on women uterine cervical (UCCa) is scarce. In this prospective study, we used a bioelectrical impedance analyzer to obtain the PA 65 UCCa. We compared health-related inflammatory nutritional indicators between normal PA. mean age was 52 ± 13. groups differed in terms C-reactive protein (15.8 19.6 versus 6.82 5.02, p = 0.022), glucose (125.39 88.19 88.78 23.08, 0.021), albumin (3.9 0.39 4.37 0.30, 0.000), EORTC QLQ-C30 loss appetite symptom scale score (33.33 (0.0-100.00) 0.0 (0.0-0.0), 0.005), QLQ-CX24 menopausal symptoms (0.0 (0.0-33.33) (0.0-100.0), 0.03). main finding present study interaction obesity as critical cofactors UCCa adeno adenosquamous histologic variants, greater extent than squamous carcinoma.

Language: Английский

Citations

2
Covariate dependent Markov chains constructed with gradient boost modeling can effectively generate long-term predictions of obesity trends DOI Creative Commons
Alexander A. Huang, Samuel Y. Huang

BMC Research Notes, Journal Year: 2023, Volume and Issue: 16(1)

Published: Nov. 24, 2023

Abstract Importance The prevalence of obesity among United States adults has increased from 30.5% in 1999 to 41.9% 2020. However, despite the recognition long-term weight gain as an important public health issue, there is a paucity studies studying and building models for projection. Methods A retrospective, cross-sectional cohort study using publicly available National Health Nutrition Examination Survey (NHANES 2017–2020) was conducted patients who completed questionnaire had accurate data both at time survey ten years ago. Multistate gradient boost modeling classifiers were used generate covariate dependent transition matrices Markov chains utilized multistate modeling. Results Of 6146 that met inclusion criteria, 3024 (49%) male 3122 (51%) female. There 2252 (37%) White patients, 1257 (20%) Hispanic 1636 Black 739 (12%) Asian patients. average BMI 30.16 (SD = 7.15), 83.67 kilos 22.04), change 3.27 kg 14.97) increase body (Fig. 1). total 2411 (39%) lost weight, 3735 (61%) gained (Table We observed 87 (1%) underweight (BMI < 18.5), 2058 (33%) normal (18.5 ≤ 25), 1376 (22%) overweight (25 30) 2625 (43%) obese > 30). From analysis transitions between normal/underweight, overweight, obese, we after 10 years, underweight, 65% stayed 32% became 2% obese. After 3% 78% 17% 71% 0% 14% 15% 84% 1% overweight. Conclusions are risk transitioning becoming or Covariate constructed with can effectively predictions.

Language: Английский

Citations

1
Covariate dependent Markov chains constructed with gradient boost modeling can effectively generate long-term predictions of obesity trends DOI Creative Commons
Alexander C. Huang, Samuel Y. Huang

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 3, 2023

Abstract Importance: The prevalence of obesity among United States adults has increased from 30.5% in 1999 to 41.9% 2020. However, despite the recognition long-term weight gain as an important public health issue, there is a paucity studies studying and building models for projection. Methods: A retrospective, cross-sectional cohort study using publicly available National Health Nutrition Examination Survey (NHANES 2017–2020) was conducted patients who completed questionnaire had accurate data both at time survey ten years ago. Multistate gradient boost modeling classifiers were used generate covariate dependent transition matrices Markov chains utilized multistate modeling. Results: Of 6,146 that met inclusion criteria, 3,024 (49%) male 3,122 (51%) female. There 2,252 (37%) White patients, 1,257 (20%) Hispanic 1,636 Black 739 (12%) Asian patients. average BMI 30.16 (SD = 7.15), 83.67 kilos 22.04), change 3.27 kg 14.97) increase body (Fig. 1). total 2,411 (39%) lost weight, 3,735 (61%) gained (Table We observed 87 (1%) underweight (BMI < 18.5), 2,058 (33%) normal (18.5 ≤ 25), 1,376 (22%) overweight (25 30) 2,625 (43%) obese > 30). From analysis transitions between normal/underweight, overweight, obese, we after 10 years, underweight, 65% stayed 32% became 2% obese. After 3% 78% 17% 71% 0% 14% 15% 84% 1% overweight. Conclusions: are risk transitioning becoming or Covariate constructed with can effectively predictions.

Language: Английский

Citations

0
Diagnosis of complex breast cysts using X-ray pneumocystography and endoscopic mammocystoscopy DOI Creative Commons
O. A. Aksonov

Reproductive Endocrinology, Journal Year: 2022, Volume and Issue: 66, P. 98 - 103

Published: Aug. 10, 2022

Background. Complex cysts of the breast (CCB), in contrast to simple and complicated cysts, are characterized by a high (up 31.0%) oncological potential. Mammography ultrasound (US) as most common methods radiological diagnosis do not allow classify CCB on benign malignant, case cancer (BC) detected establishment its molecular genetic subtype.Objectives: analyze popularize own experience using endoscopic mammocystoscopy (EMCS) X-ray pneumocystography (RPCG) for biopsy navigation. Materials methods. The clinical anamnestic data, results radiological, pathomorphological studies 286 adult women with simple, were analyzed (n = 45, 134 142, respectively).Results. diagnostic navigation capabilities US limited frequent (18.1%) false-negative results, which caused atypical echosemiotics CCB. Trepan-biopsy under control becomes impossible when visualization disappears, often occurs during fine-needle aspiration liquid component. Technical difficulties arise imitating puncture needle linear hyperechoic structures induced Cooper’s ligaments, well positioning bulky, non-fixed gland. In terms specificity prognostic significance negative result, RPCG is slightly (5.6 4.7%, respectively) inferior certain situations it can be used assess likelihood BC, positive navigate stereotaxic сore biopsy. EMCS low-traumatic procedure that provides direct visual contact intracystic neoplasms, allows assessing probability BC conducting pinch biopsy.Conclusions. consistent combined use well-known author’s involvement US, according given algorithm ensures effective management at modern level.

Language: Английский

Citations

0