Toxics,
Journal Year:
2024,
Volume and Issue:
12(5), P. 320 - 320
Published: April 28, 2024
Microplastics
(MPs)
are
now
ubiquitous
environmental
contaminants
that
lead
to
unavoidable
human
exposure;
they
have
received
increasing
attention
in
recent
years
and
become
an
emerging
area
of
research.
The
greatest
concern
is
the
negative
impacts
MPs
on
marine,
fresh-water,
terrestrial
ecosystems,
as
well
health,
extent
World
Health
Organization
(WHO)
calls
for
increased
research
standardized
methods
assess
exposure
MPs.
Many
countries
international
organizations
implementing
or
proposing
legislation
this
regard.
This
review
aims
summarize
current
state
legislation,
indoor
outdoor
contamination,
potential
health
risk
due
airborne
MPs,
considering
occupational
also
becoming
a
growing
concern.
Even
though
regarding
has
continuously
last
twenty
years,
effects
been
scarcely
investigated,
toxicity
studies
still
limited
not
directly
comparable,
lack
field.
Environmental Pollution,
Journal Year:
2024,
Volume and Issue:
347, P. 123675 - 123675
Published: March 4, 2024
Stimulation
of
human
keratinocytes
with
particulate
matter
2.5
(PM2.5)
elicits
complex
signaling
events,
including
a
rise
in
the
generation
reactive
oxygen
species
(ROS).
However,
mechanisms
underlying
PM2.5-induced
ROS
production
remain
unknown.
Here,
we
show
that
is
mediated
via
NADPH
oxidase
(NOXs)
system
and
Ca2+
pathway.
PM2.5
treatment
increased
expression
NOX1,
NOX4,
calcium-sensitive
NOX,
dual
1
(DUOX1),
epidermal
keratinocyte
cell
line.
bound
to
aryl
hydrocarbon
receptor
(AhR),
this
promoter
regions
NOX1
DUOX1,
suggesting
AhR
acted
as
transcription
factor
DUOX1.
DUOX1
epigenetic
modification.
Moreover,
link
between
DNA
demethylase
histone
methyltransferase
led
an
elevation
mRNA.
Interestingly,
NOX4
promoted
interaction
channels
within
cytoplasmic
membrane
or
endoplasmic
reticulum,
leading
release.
The
increase
intracellular
concentration
activated
responsible
for
production.
Our
findings
provide
evidence
PM2.5-mediated
ROS-generating
network,
which
serves
signal
through
activation.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Jan. 10, 2024
Abstract
Several
studies
have
reported
an
increased
risk
of
chronic
kidney
disease
(CKD)
outcomes
after
long-term
exposure
(more
than
1
year)
to
particulate
matter
with
aerodynamic
diameter
≤
2.5
µm
(PM
).
However,
the
conclusions
remain
inconsistent.
Therefore,
we
conducted
this
meta-analysis
examine
association
between
PM
and
CKD
outcomes.
A
literature
search
was
in
PubMed,
Scopus,
Cochrane
Central
Register
Controlled
trials,
Embase
for
relevant
published
until
August
10,
2023.
The
main
were
incidence
prevalence
as
well
end-stage
(ESKD).
random-effect
model
meta‐analyses
used
estimate
each
outcome
among
studies.
Twenty
two
identified,
including
14
cohort
studies,
8
cross-sectional
a
total
7,967,388
participants.
This
revealed
that
10
μg/m
3
increment
significantly
associated
risks
both
[adjusted
odds
ratio
(OR)
1.31
(95%
confidence
interval
(CI)
1.24
1.40),
adjusted
OR
CI
1.03
1.67),
respectively].
In
addition,
relationship
ESKD
is
suggestive
but
not
conclusive
(adjusted
1.16;
95%
1.00
1.36).
had
consistent
across
all
subgroups
adjustment
variables.
Our
study
observed
CKD.
more
dedicated
are
required
show
causation
warrants
urgent
action
on
mitigate
global
burden
Frontiers in Genetics,
Journal Year:
2024,
Volume and Issue:
14
Published: Jan. 17, 2024
Environmental
pollution
nowadays
has
not
only
a
direct
correlation
with
human
health
changes
but
social
impact.
Epidemiological
studies
have
evidenced
the
increased
damage
to
on
daily
basis
because
of
ecological
niche.
Rapid
urban
growth
and
industrialized
societies
importantly
compromise
air
quality,
which
can
be
assessed
by
notable
accumulation
pollutants
in
both
gas
particle
phases.
Of
them,
particulate
matter
(PM)
represents
highly
complex
mixture
organic
inorganic
compounds
most
variable
size,
composition,
origin.
PM
being
one
environmental
pollutants,
its
also
varies
temporal
spatial
manner,
challenges
current
analytical
techniques
used
investigate
interactions.
Nevertheless,
characterization
chemical
composition
is
reliable
indicator
atmosphere,
quality
breathed
urbanized
societies,
industrial
zones
consequently
gives
support
for
pertinent
measures
avoid
serious
damage.
Epigenomic
promising
biological
mechanisms
pollution-derived
carcinogenesis.
Therefore,
this
review
aims
highlight
implication
exposure
diverse
molecular
driving
diseases
altered
epigenetic
regulation.
The
presented
findings
context
pan-organic
cancer,
fibrosis,
neurodegeneration
metabolic
may
provide
valuable
insights
into
toxicity
effects
components
at
epigenomic
level
serve
as
biomarkers
early
detection
novel
targeted
therapies.
Toxics,
Journal Year:
2024,
Volume and Issue:
12(5), P. 320 - 320
Published: April 28, 2024
Microplastics
(MPs)
are
now
ubiquitous
environmental
contaminants
that
lead
to
unavoidable
human
exposure;
they
have
received
increasing
attention
in
recent
years
and
become
an
emerging
area
of
research.
The
greatest
concern
is
the
negative
impacts
MPs
on
marine,
fresh-water,
terrestrial
ecosystems,
as
well
health,
extent
World
Health
Organization
(WHO)
calls
for
increased
research
standardized
methods
assess
exposure
MPs.
Many
countries
international
organizations
implementing
or
proposing
legislation
this
regard.
This
review
aims
summarize
current
state
legislation,
indoor
outdoor
contamination,
potential
health
risk
due
airborne
MPs,
considering
occupational
also
becoming
a
growing
concern.
Even
though
regarding
has
continuously
last
twenty
years,
effects
been
scarcely
investigated,
toxicity
studies
still
limited
not
directly
comparable,
lack
field.
