The effects of COVID-19 on cognitive performance in a community-based cohort: A COVID Symptom Study Biobank observational study DOI Creative Commons
Nathan J. Cheetham, Rose Penfold, Valentina Giunchiglia

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: March 19, 2023

Abstract Background Cognitive impairment has been reported after many types of infection, including SARS-CoV-2. Whether deficits following SARS-CoV-2 improve over time is unclear. Studies to date have focused on hospitalised individuals with up a year follow-up. The presence, magnitude, persistence and correlations effects in community-based cases remain relatively unexplored. Methods performance (working memory, attention, reasoning, motor control) was assessed participants voluntary biobank July, 2021 (Round 1), April, 2022 2). Participants, drawn from the COVID Symptom Study smartphone app, comprised without infection varying symptom duration. Effects COVID-19 exposures cognitive accuracy reaction scores were estimated using multivariable ordinary least squares linear regression models weighted for inverse probability participation, adjusting potential confounders mediators. role ongoing symptoms examined stratifying self-perceived recovery. Longitudinal analysis change between rounds. Findings 3335 completed Round 1, whom 1768 also 2. At previous positive tests had lower (N = 1737, β −0.14 standard deviations, SDs) than negative controls. Deficits largest ≥ 12 weeks 495, −0.22 SDs). comparable hospital presentation during illness 281, −0.31 SDs), 10 years age difference (60-70 vs. 50-60 years, −0.21 whole study population. Stratification by self-reported recovery revealed that only detectable who did not feel recovered COVID-19, whereas full showed no deficits. evidence time, suggesting affected persisted at almost 2 since initial infection. Interpretation nearly two post longer durations, symptoms, and/or more severe However, such detected COVID-19. Further work needed monitor develop understanding mechanisms those symptoms. Funding Chronic Disease Research Foundation, Wellcome Trust, National Institute Health Care Research, Medical Council, British Heart Alzheimer’s Society, European Union, Driver Relief Fund, French Agency. context Evidence before this Abstracts screened PubMed search query (COVID-19) AND (long COVID) (cognitive impairment), which returned 409 results 2020 January 20, 2023. Multiple systematic reviews meta-analyses consistent observation Most studies used small samples less 200 (including any controls), cohorts, measured through self-report or dichotomised quantitative scales. Only one found sample size 1,000 individuals, included controls across both community settings, objective testing allowed estimation scale impairment. Previous limited insofar as focusing earlier infections first pandemic, prior introduction vaccination emerging variants. longitudinal follow-up long low rates long-term Added value We report quantitatively large dataset 4,000 test-confirmed range associated mostly cases. Importantly, we undertook rounds allowing tracking performance. Our methods us variants emerged 2022, previously studied cognition. Implications all available This adds existing but finds important exceptions. mid-2021, are feeling even longest In mid-2022, find appear persistent smaller studies. More research required experiencing understand underlying

Language: Английский

Long COVID neuropsychological follow-up: Is cognitive rehabilitation relevant? DOI Open Access
Lúcia Willadino Braga, Sandro Barbosa de Oliveira,

Andrea Suhet Moreira

et al.

Neurorehabilitation, Journal Year: 2023, Volume and Issue: 53(4), P. 517 - 534

Published: Dec. 19, 2023

BACKGROUND: Duration of neuropsychological disorders caused by long COVID, and the variables that impact outcomes, are still largely unknown. OBJECTIVE: To describe cognitive profile patients with COVID post-participation in a rehabilitation program subsequent reassessment identify factors influence recovery. METHODS: 208 (mean age 48.8 y.o.), mostly female, were reevaluated 25 months after their first infection 17 initial evaluation. Patients underwent subjective assessment, Barrow Neurological Institute Screen for Higher Cerebral Functions (BNIS), Phonemic Verbal Fluency Clock Drawing Tests (NEUPSILIN) executive functions, Hospital Anxiety Depression Scale (HADS) WHOQol-Bref. RESULTS: We noted discrete improvement symptoms acute stage COVID-19; nonetheless, performance was not within normative parameters standardized testing. These results negatively QoL corroborate patients’ assessments issues experienced daily life. Improvement seen those who participated psychoeducational rehabilitation, had higher levels education, lower depression scores on HADS. CONCLUSION: Our data reveal persistence long-term neuropsychiatric COVID. Neuropsychological is shown to be important, whether in-person or online.

Language: Английский

Citations

5
E-cigarette use or dual use of E-cigarette and combustible cigarette and mental health and cognitive impairment: Findings from the National Health Interview Survey, 2020–2021 DOI
Jiahui Cai, Aurelian Bidulescu

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 351, P. 878 - 887

Published: Jan. 9, 2024

Language: Английский

Citations

1
Clinical and serological predictors of post COVID-19 condition–findings from a Canadian prospective cohort study DOI Creative Commons
Erin Collins,

Yannick Galipeau,

Corey Arnold

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: May 9, 2024

More than 3 years into the pandemic, there is persisting uncertainty as to etiology, biomarkers, and risk factors of Post COVID-19 Condition (PCC). Serological research data remain a largely untapped resource. Few studies have investigated potential relationships between post-acute serology PCC, while accounting for clinical covariates.

Language: Английский

Citations

1
Persistent Cognitive Dysfunction in a Non-Hospitalized COVID-19 Long-Hauler Patient Responding to Cognitive Rehabilitation and Citicoline Treatment DOI Creative Commons
Roberto Monastero, Roberta Baschi

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(9), P. 1275 - 1275

Published: Sept. 1, 2023

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is characterized by severe flu-like symptoms, which can progress to life-threatening systemic inflammation and multiorgan dysfunction. nervous system involved in over one-third of patients, the most common neurological manifestations concern central system, such as headache, fatigue, brain fog. activation innate, humoral, cellular immune responses, resulting a cytokine storm endothelial mitochondrial dysfunctions, are main pathophysiological mechanisms SARS-CoV-2 infection. Citicoline an exogenous source choline cytidine intracellular phospholipid synthesis, improves blood flow, activity, This report will present case non-hospitalized, 59-year-old female. After mild form infection, patient developed cognitive disturbances forgetfulness anomia. multidimensional neuropsychological assessment revealed impairment episodic memory with borderline performance executive visuospatial functioning. Cognitive rehabilitation treatment citicoline 1000 mg/daily led marked improvement symptoms after six months. Early identification sequelae Disease 2019 (COVID-19) timely interventions required non-hospitalized long-hauler patients COVID-19. Long-term should be considered potentially effective improving functioning subjects Post COVID-19 Neurological Syndrome.

Language: Английский

Citations

3
The effects of COVID-19 on cognitive performance in a community-based cohort: A COVID Symptom Study Biobank observational study DOI Creative Commons
Nathan J. Cheetham, Rose Penfold, Valentina Giunchiglia

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: March 19, 2023

Abstract Background Cognitive impairment has been reported after many types of infection, including SARS-CoV-2. Whether deficits following SARS-CoV-2 improve over time is unclear. Studies to date have focused on hospitalised individuals with up a year follow-up. The presence, magnitude, persistence and correlations effects in community-based cases remain relatively unexplored. Methods performance (working memory, attention, reasoning, motor control) was assessed participants voluntary biobank July, 2021 (Round 1), April, 2022 2). Participants, drawn from the COVID Symptom Study smartphone app, comprised without infection varying symptom duration. Effects COVID-19 exposures cognitive accuracy reaction scores were estimated using multivariable ordinary least squares linear regression models weighted for inverse probability participation, adjusting potential confounders mediators. role ongoing symptoms examined stratifying self-perceived recovery. Longitudinal analysis change between rounds. Findings 3335 completed Round 1, whom 1768 also 2. At previous positive tests had lower (N = 1737, β −0.14 standard deviations, SDs) than negative controls. Deficits largest ≥ 12 weeks 495, −0.22 SDs). comparable hospital presentation during illness 281, −0.31 SDs), 10 years age difference (60-70 vs. 50-60 years, −0.21 whole study population. Stratification by self-reported recovery revealed that only detectable who did not feel recovered COVID-19, whereas full showed no deficits. evidence time, suggesting affected persisted at almost 2 since initial infection. Interpretation nearly two post longer durations, symptoms, and/or more severe However, such detected COVID-19. Further work needed monitor develop understanding mechanisms those symptoms. Funding Chronic Disease Research Foundation, Wellcome Trust, National Institute Health Care Research, Medical Council, British Heart Alzheimer’s Society, European Union, Driver Relief Fund, French Agency. context Evidence before this Abstracts screened PubMed search query (COVID-19) AND (long COVID) (cognitive impairment), which returned 409 results 2020 January 20, 2023. Multiple systematic reviews meta-analyses consistent observation Most studies used small samples less 200 (including any controls), cohorts, measured through self-report or dichotomised quantitative scales. Only one found sample size 1,000 individuals, included controls across both community settings, objective testing allowed estimation scale impairment. Previous limited insofar as focusing earlier infections first pandemic, prior introduction vaccination emerging variants. longitudinal follow-up long low rates long-term Added value We report quantitatively large dataset 4,000 test-confirmed range associated mostly cases. Importantly, we undertook rounds allowing tracking performance. Our methods us variants emerged 2022, previously studied cognition. Implications all available This adds existing but finds important exceptions. mid-2021, are feeling even longest In mid-2022, find appear persistent smaller studies. More research required experiencing understand underlying

Language: Английский

Citations

2