Endometriosis: Part I. Basic concept

Taiwanese Journal of Obstetrics and Gynecology, Journal Year: 2022, Volume and Issue: 61(6), P. 927 - 934

Published: Nov. 1, 2022

Language: Английский

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Obesity and female infertility

Best Practice & Research Clinical Obstetrics & Gynaecology, Journal Year: 2023, Volume and Issue: 89, P. 102336 - 102336

Published: April 8, 2023

Infertility is a significant global health issue, with negative impact on people's wellbeing and human rights. Despite the longstanding association between obesity infertility, there remains uncertainty, about precise mechanisms underpinning this best management strategies. In article, we aimed to address these uncertainties by reviewing recent literature, focusing studies which evaluated live birth rates. We found that just over half of studies, investigating relationship preconception maternal weight rates an inverse correlation. There was, however, insufficient evidence, lifestyle or pharmacological interventions in obese women resulted improved The implications for clinical practice future research are highlighted. For example, need consider some flexibility applying strict body mass index targets, limiting access fertility treatment, large trials new options bariatric surgery.

Language: Английский

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Polycystic Ovarian Syndrome (PCOS): Does the Challenge End at Conception?

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(22), P. 14914 - 14914

Published: Nov. 12, 2022

Polycystic ovary syndrome (PCOS) is a prevalent condition that not only has the potential to impede conception but also represents most common endocrine dysfunction in fertile women. It considered heterogeneous and multifaceted disorder, with multiple reproductive metabolic phenotypes which differently affect early- long-term syndrome’s risks. Undoubtedly, impact of PCOS on infertility attracted attention healthcare providers investigators. However, there growing evidence even after achieved, predisposes parturient several adverse pregnancy outcomes including high risk pregnancy-induced hypertension, spontaneous abortion, gestational diabetes, preeclampsia, preterm birth, increase risks stillbirth neonatal death. Fetal growth abnormalities may be more common, relationship less well defined. This narrative review aims summarize current knowledge regarding these conditions as they interplay concludes although appears an complications during women PCOS, need for further research clarify possible confounding obesity. Implications clinical practice future are outlined.

Language: Английский

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The Impact of High BMI on Pregnancy Outcomes and Complications in Women with PCOS Undergoing IVF—A Systematic Review and Meta-Analysis

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(6), P. 1578 - 1578

Published: March 10, 2024

(1) Background: Current evidence indicates that women with polycystic ovarian syndrome (PCOS) undergoing in vitro fertilization (IVF) have an increased likelihood of adverse pregnancy outcomes. The objective this systematic review was to clarify the role a PCOS-related high body mass index (BMI) these unfavourable (2) Methods: A comprehensive search electronic databases conducted identify studies investigating impact BMI on outcomes PCOS IVF. RevMan software (v5.4) used calculate odds ratio (OR) and 95% confidence interval (CI). (3) Results: Nineteen eligible (n = 7680) were identified, including 16 retrospective cohort 6934), two prospective 525), one cross-sectional study 221). Pooled analysis showed significantly higher clinical (OR, 1.16 [95% CI, 1.04–1.29]; z 2.73; p 0.006; I2 30%) livebirths 1.88 1.56–2.27]; 6.54; < 0.0001; 55%) normal versus BMI. Meta-analysis miscarriages 0.76 0.60–0.95]; 2.42; 0.02; 53%). three 993) ORs gestational diabetes mellitus (OR 3.96 CI 1.62–9.68]; 3.01; 0.003; 58%) hypertension 2.16 1.32–3.54]; 3.05; 0.002; 68%) reported greater caesarean section for 0.45 0.29–0.69]; 3.66; 0.0003; 0%). (4) Conclusions: observed IVF seems be attributable

Language: Английский

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Higher pre‐pregnancy body mass index was associated with adverse pregnancy and perinatal outcomes in women with polycystic ovary syndrome after a freeze‐all strategy: A historical cohort study

Acta Obstetricia Et Gynecologica Scandinavica, Journal Year: 2024, Volume and Issue: 103(5), P. 884 - 896

Published: Jan. 12, 2024

Abstract Introduction Previous studies have demonstrated that abnormal body mass index (BMI) is associated with adverse pregnancy outcomes in frozen–thawed embryo transfer cycles. However, the relationship between BMI and perinatal patients polycystic ovary syndrome (PCOS) remains unclear. Furthermore, whether a diagnosis of PCOS could result women different BMIs unknown. Material methods A historical cohort study included 1667 12 256 without after freeze‐all policy January 2016 December 2020. The encompassed both outcomes. Multivariate logistic regression analysis restricted cubic spline models were performed to eliminate confounding factors when investigating Results After controlling for covariates, comparable underweight normal weight PCOS. overweight had lower clinical rate an overall live birth rate. obesity multiple pregnancies but higher biochemical than group. Additionally, showed as maternal increased 32 kg/m 2 , blastocyst decreased, risks preterm birth, gestational diabetes mellitus, macrosomia, large‐for‐gestational age (LGA) very LGA strategy. Moreover, resulted risk small‐for‐gestational group exhibited mellitus compared Conclusions This detrimental impact on undergoing it was only statistically significant complications women.

Language: Английский

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Exploring Potential Biomarkers in Recurrent Pregnancy Loss: A Literature Review of Omics Studies to Molecular Mechanisms

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2263 - 2263

Published: March 4, 2025

Recurrent pregnancy loss (RPL) is characterized by the occurrence of three or more consecutive spontaneous losses before 20-24 weeks gestation. Despite significant progress in investigation biological pathways associated with unexplained RPL, precise molecular mechanisms remain elusive. Recent advances multi-omics approaches have identified numerous biomarkers that offer potential avenues for understanding underlying complexities RPL. The aim this comprehensive literature review was to investigate functional roles these candidate markers and explore possible key may contribute We also aimed elucidate networks predicted omics analyses, which hold promise providing invaluable insights into novel diagnostic therapeutic strategies women experiencing Furthermore, expands on clinical implications applications, highlighting those currently moving towards use ongoing studies developing direction.

Language: Английский

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Favorable pregnancy outcome in a patient with morbid obesity, type 2 diabetes mellitus and extremely high baseline proteinuria

Nephrology and Dialysis, Journal Year: 2025, Volume and Issue: 27(1), P. 84 - 93

Published: March 22, 2025

The prevalence of type 2 diabetes mellitus (DM2) and obesity in pregnant women is increasing, particularly those advanced reproductive age. DM2, arterial hypertension (AH), proteinuria, renal insufficiency significantly elevate the risk pregnancy complications, including preeclampsia (PE), preterm birth, cesarean section (CS), congenital malformations, neonatal respiratory metabolic disorders, accelerated progression chronic kidney disease mothers. This article describes a case unplanned 45-year-old woman with morbid (BMI 50.39), AH, extremely high proteinuria (12 g/day), pregestational serum creatinine 210 μmol/L. patient declined medical recommendations for termination. She was prescribed insulin detemir aspart, achieving target HbA1C level below 6%. Acetylsalicylic acid enoxaparin were administrated to prevent PE thromboembolic complications. Antihypertensive therapy adjusted multiple times based on 24-h blood pressure monitoring. By 26 weeks gestation, received methyldopa, extended-release nifedipine, bisoprolol. No or fetal growth restrictions observed. At 36 4 days planned CS performed due breech presentation. A female infant diabetic fetopathy delivered weight 3290 g, height 51 cm, Apgar score – 7/8 points. postpartum period uneventful, both mother child discharged at eighth day. remains healthy developing normally. resumed nephroprotective but, by her own decision, lost follow-up after six months. It known she began regular hemodialysis 1.5 years postpartum. favorable obstetric outcome achieved through multidisciplinary management, complication prevention, strict glycemic control.

Language: Английский

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To do one and to get more: Part II. Diabetes and metabolic dysfunction-associated fatty liver diseases

Journal of the Chinese Medical Association, Journal Year: 2022, Volume and Issue: unknown

Published: Oct. 21, 2022

Type 2 diabetes mellitus (DM) is characterized by inability of faulty pancreatic β-cells to secret a normal amount insulin maintain body consumption, and/or peripheral tissue has decreased susceptibility insulin, resulting in hyperglycemia and resistance. Similar other chronic systemic inflammatory diseases, DM result from dysregulated interactions between ethnic, genetic, epigenetic, immunoregulatory, hormonal environmental factors. Therefore, it rational suppose the concept as “To do one get more”, while using anti-diabetic agents (ADA), main pharmacologic agent for treatment DM, can provide an extra-glycemia effect on co-morbidities or concomittent DM. In this review, based much strong correlation metabolic dysfunction-associated fatty liver diseases (MAFLD) shown similar pathophysiological mechanisms high prevalence MAFLD its vice versa (a DM), possible use strategy target both simultaneously. We focus new classification ADA, such glucagon-like peptide 1 receptor (GLP1R) agonist sodium-glucose cotransporter-2 (SGLT-2) inhibitors show potential benefits extra-glycemic MAFLD. conclude that management patients, especially those who need ADA adjuvant therapy should include healthy lifestyle modification overcome syndrome, contributing urgent effective weight reduction strategy. GLP1R weight-lowering medications, which may be better choice complicated with its-associated severe form MASH, although role SGLT-2 are also impressive. The prescription these two classes satisfy successful sugar-lowering controlling hepatoprotective activity patients.

Language: Английский

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Function of the granulosa cells in women with polycystic ovary syndrome

Taiwanese Journal of Obstetrics and Gynecology, Journal Year: 2024, Volume and Issue: 63(2), P. 141 - 143

Published: March 1, 2024

Language: Английский

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Polycystic ovary syndrome and miscarriage: a narrative review

F&S Reviews, Journal Year: 2024, Volume and Issue: 5(4), P. 100078 - 100078

Published: Aug. 13, 2024

Language: Английский

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