Research Square (Research Square),
Journal Year:
2022,
Volume and Issue:
unknown
Published: Nov. 7, 2022
Abstract
Hypoxia
exerts
detrimental
effects
on
steroidogenesis
and
male
fertility.
Melatonin,
a
neuroendocrine
hormone,
modulates
steroid
production
in
mammals
through
its
membrane
receptors.
This
study
examined
the
of
melatonin
treatment
dysfunction
testosterone
impairment
following
CoCl2-induced
hypoxia
TM3
Leydig
cells.
The
results
indicated
that
CoCl2
caused
HIF1α
overexpression
these
Moreover,
cells
led
to
considerable
downregulation
StAR,
3β-HSD
GATA-4
as
well
receptors
MT1
MT2
mRNA/protein
expression
coupled
with
content
repression
cell
culture
medium.
Melatonin
administration
inhibited
expression,
but
had
no
significant
effect
3β-HSD,
GATA-4,
or
level
reduced
decrease
gene
protein
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(19), P. 14959 - 14959
Published: Oct. 6, 2023
Manganese
(Mn)
is
an
essential
trace
element
with
unique
functions
in
the
body;
it
acts
as
a
cofactor
for
many
enzymes
involved
energy
metabolism,
endogenous
antioxidant
enzyme
systems,
neurotransmitter
production,
and
regulation
of
reproductive
hormones.
However,
overexposure
to
Mn
toxic,
particularly
central
nervous
system
(CNS)
due
causing
progressive
destruction
nerve
cells.
Exposure
manganese
widespread
occurs
by
inhalation,
ingestion,
or
dermal
contact.
Associations
have
been
observed
between
accumulation
neurodegenerative
diseases
such
manganism,
Alzheimer's
disease,
Parkinson's
Huntington's
amyotrophic
lateral
sclerosis.
People
genetic
associated
mutation
gene
impaired
excretion,
kidney
iron
deficiency,
vegetarian
diet
are
at
particular
risk
excessive
exposure
Mn.
This
review
has
collected
data
on
current
knowledge
source
exposure,
experimental
supporting
dispersive
brain,
controversies
surrounding
reference
values
biomarkers
related
status
different
matrices,
competitiveness
other
metals,
(Fe),
magnesium
(Mg),
zinc
(Zn),
copper
(Cu),
lead
(Pb),
calcium
(Ca).
The
disturbed
homeostasis
body
connected
susceptibility
diseases,
fertility,
infectious
diseases.
evidence
involvement
metabolic
type
2
diabetes
mellitus/insulin
resistance,
osteoporosis,
obesity,
atherosclerosis,
non-alcoholic
fatty
liver
was
discussed.
Ultrastructural Pathology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 21
Published: Jan. 11, 2025
There
is
an
important
concern
about
the
potential
health
and
environmental
risks
that
may
develop
due
to
exposure
copper
oxide
nanoparticles
(CuO-NPs).
Selenium
essential
trace
element.
It
supports
expression
of
a
variety
selenoproteins.
The
present
study
was
designed
ultrastructural
biochemical
changes
in
adult
rat
ovary
after
oral
administration
CuO-NPs
assess
possible
ameliorative
influence
Selenium.
Sixty
female
albino
rats
were
divided
two
major
groups:
Group
I
II.
further
subdivided
into
three
IA
(control),
IB:
received
single
high
dose
2000
mg/kg
CuO-NPs,
IC:
selenium
(0.5
mg/kg),
five
days
before
giving
(2000
mg/kg).
Thereafter,
given
for
14
days.
II
IIA
IIB:
small
300
28
days,
IIC:
starting
concomitant
(300
mg/kg)
Damage
ovarian
features,
increased
MDA
levels,
decreased
serum
estrogen
progesterone
hormones
levels
detected
group
IB
IIB.
IC
IIC
showed
improvement
ultrastructural,
as
compared
IIB
indicating
could
decrease
damage
induced
by
ovaries.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(12), P. 2799 - 2799
Published: June 19, 2023
The
anthropogenic
environment
and
diet
introduce
many
metals
into
the
human
body,
both
essential
toxic.
Absorption
leads
to
systemic
exposure
accumulation
in
body
fluids
tissues.
Both
excess
deficiency
of
trace
elements
are
health
hazards.
primary
aim
present
study
was
evaluate
concentration
51
liver
samples
11
selected
brain
regions
obtained
at
post-mortem
examination
from
a
population
adults
living
south-eastern
Poland
(n
=
15).
A
total
180
analyses
were
performed
by
inductively
coupled
plasma
mass
spectrometry
two
independent
replicates.
collected
data
show
very
high
individual
variability
content
investigated
elements.
Macroelements
such
as
sodium,
magnesium,
phosphorus,
potassium,
calcium,
iron,
zinc
occurred
highest
concentrations
with
greatest
statistically
significant
variations.
Although
elemental
differed
significantly,
strongest
positive
correlation
between
polus
frontalis
observed
for
element
selenium
(0.9338)
negative
one
manganese
(-0.4316)
lanthanum
(-0.5110).
areas
studied
have
different
requirements
manganese,
molybdenum.
In
addition,
males
had
significantly
(p
<
0.05)
higher
lanthanides
actinides
than
females.
results
this
that
inhabitants
exposed
fairly
uniform
aluminum
vanadium
brain,
which
affinity
thalamus
dorsalis.
This
result
proves
there
is
environmental
these
Agronomy,
Journal Year:
2022,
Volume and Issue:
12(10), P. 2480 - 2480
Published: Oct. 12, 2022
Globally,
the
demand
for
food
is
increasing
day
by
due
to
rapid
increase
in
human
population.
Elevated
levels
of
metals
and
metalloids
soils
are
biomagnified
over
time
crops
cultivated
metal-contaminated
soils,
hence
posing
a
risk
chain
contamination.
The
present
investigation
aimed
assess
metal
metalloid
concentrations
soil,
water,
rice
kernels
which
widely
four
districts
Punjab,
Pakistan,
determine
health.
results
revealed
that,
five
varieties,
super
basmati
was
most
preferred
farmers
its
yield
potential
consumer
acceptance
taste
long
kernel.
A
detailed
analysis
accumulation
that
their
mean
concentration
fluctuated
samples
study
area.
decreasing
trends
heavy
were
observed
be
Pb
>
Cu
As
Cr
Cd
Hg
Al
soil
samples,
water
=
kernels.
bioconcentration
factor
highest
Faisalabad
area
among
all
sampled
sites.
pollution
load
index
As,
Cd,
registered
values,
above
recommended
safety
threshold
described
World
Health
Organization.
health
determined
low
at
sites
except
Hg.
These
point
risks
caused
consumption
fragrant
humans.
Regular
monitoring
manage
control
elevated
related
hazards
as
result
use
contaminated
metalloids.
