Influence of subclinical hypothyroidism and brain-derived neurotropic factor on telomere length dynamics in type 1 diabetic pregnancies and their newborns
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Jan. 2, 2025
Thyroid
dysfunctions
are
common
in
type
1
diabetes
mellitus
(T1DM)
pregnancies,
impacting
embryogenesis
and
fetal
neurodevelopment.
This
study
investigates
the
effects
of
subclinical
hypothyroidism
BDNF
(Brain-derived
neurotrophic
factor)
telomere
length
T1DM
mothers
their
newborns.
In
a
recent
study,
researchers
found
an
inverse
relationship
between
TSH
(thyroid-stimulating
hormone)
levels
cord
blood
was
prospective
cohort
analysis
70
newborns
with
T1DM.
The
measured
leukocyte
(LTL)
maternal
neonatal
samples.
Subclinical
during
first
trimester
characterized
by
ranging
from
2.5
to
5.0
mIU/L
alongside
normal
free
thyroxine
(FT4)
concentrations.
this
we
proved
that
predicts
newborn.
Furthermore,
investigated
influence
on
Maternal
pregnancy
has
strong
shortening
newborn
telomeres.
positive
effect
length.
These
results
can
have
important
impact
subsequent
development
child
born
diabetic
mother.
Health
disease
associated
later
life
may
be
programmed
at
birth.
Language: Английский
ASSOCIAÇÕES ENTRE A SOLIDÃO E A SAÚDE FISÍCA E PSIQUICA DA PESSOA IDOSA: Uma revisão integrativa
Psicologia e Saúde em Debate,
Journal Year:
2025,
Volume and Issue:
11(1), P. 457 - 476
Published: Feb. 26, 2025
The
aging
process
is
characterized
by
various
facets,
being
both
subjective
and
natural,
it
progresses
without
alteration.
During
this
process,
elderly
individuals
may
experience
social
isolation
or
loneliness,
which
has
been
associated
with
significant
impacts
on
their
physical,
psychological,
health.
This
study
aimed
to
examine
the
evidence
in
scientific
literature
regarding
association
between
loneliness
its
impact
cognitive,
emotional
health
of
older
adults.
It
an
integrative
review
conducted
across
following
databases:
National
Library
Medicine
Institutes
Health
(PubMed),
Virtual
(BVS),
Psychinfo,
Scielo,
Pepsic,
Capes
Theses
Portal,
Lilacs,
utilizing
descriptors
indexed
MeSH
Terms
DeCS,
specifically:
"Loneliness
Social
Isolation,"
AND
"Depression
Cognitive
Disorder,"
"Aging
Senescence."
A
total
116
articles
were
retrieved,
13
deemed
eligible
for
analysis.
results
highlight
cognitive
decline,
depressive
symptoms,
anxiety
detrimental
behaviors.
Conversely,
support
emerges
as
a
strong
protective
factor
coping
mechanism
against
Language: Английский
How does loneliness “get under the skin” to become biologically embedded?
Biodemography and Social Biology,
Journal Year:
2023,
Volume and Issue:
68(4), P. 115 - 148
Published: Oct. 2, 2023
ABSTRACTLoneliness
is
linked
to
declining
physical
health
across
cardiovascular,
inflammatory,
metabolic,
and
cognitive
domains.
As
a
result,
loneliness
increasingly
being
recognized
as
public
threat,
though
the
mechanisms
that
have
been
studied
do
not
yet
explain
all
loneliness-related
risk.
Potential
include
having
1.)
direct,
causal
impacts
on
health,
possibly
maintained
by
epigenetic
modification,
2.)
indirect
effects
mediated
through
health-limiting
behaviors,
3.)
artifactual
associations
perhaps
related
genetic
overlap
reverse
causation.
In
this
scoping
review,
we
examine
evidence
surrounding
each
of
these
pathways,
with
particular
emphasis
emerging
research
effects,
in
order
evaluate
how
becomes
biologically
embedded.
We
conclude
there
are
significant
gaps
our
knowledge
psychosocial
stress
may
lead
physiological
changes,
so
more
work
needed
understand
if,
how,
when
has
direct
influence
health.
Hypothalamic-pituitary
adrenocortical
axis
disruptions
changes
gene
expression
methylation
activity
transcription
factor
proteins
one
promising
area
but
confounded
number
unmeasured
factors.
Therefore,
wok
using
causally
informative
designs,
such
twin
family
studies
intensively
longitudinal
diary
studies.
Disclosure
statementWe
no
known
conflict
interest
disclose.Notes1
The
primary
databases
used
for
search
were
PubMed,
Google
Scholar,
PsycNet.
literature
was
conducted
between
January
May
2023,
given
broad
scope
topic,
possibility
exhaustive.2
When
considering
epigenetics,
transcriptomics,
telomeres,
reviewed
both
constructs
(e.g.,
relational
support)
while,
evaluating
other
review
focuses
primarily
loneliness.3
second-generation
clocks
be
empirical
commonly,
it
could
argued
trained
age
alone,
they
index
general
biological
construct,
rather
than
strictly
acceleration.4
Some
recent
consistent
finding
predicts
decreased
future
Yang
et
al.
Citation2022)
null
reported
well
(Kobayashi
Steptoe
Citation2018;
Schrempft
Citation2019).Additional
informationFundingCDF
supported
National
Institute
Drug
Abuse
(T32DA050560).
Language: Английский
Loneliness among elderly people as a public health threat
Anna Susło,
No information about this author
Sylwia Mizia,
No information about this author
Ewa Pochybełko
No information about this author
et al.
Family Medicine & Primary Care Review,
Journal Year:
2023,
Volume and Issue:
25(1), P. 107 - 110
Published: Jan. 1, 2023
ENWEndNote
BIBJabRef,
Mendeley
RISPapers,
Reference
Manager,
RefWorks,
Zotero
AMA
Susło
A,
Mizia
S,
Pochybełko
E,
Horoch-Łyszczarek
E.
Loneliness
among
elderly
people
as
a
public
health
threat.
Family
Medicine
&
Primary
Care
Review.
2023;25(1):107-110.
doi:10.5114/fmpcr.2023.126026.
APA
Susło,
A.,
Mizia,
S.,
Pochybełko,
E.,
Horoch-Łyszczarek,
(2023).
Review,
25(1),
107-110.
https://doi.org/10.5114/fmpcr.2023.126026
Chicago
Anna,
Sylwia
Ewa
and
Horoch-Łyszczarek.
2023.
"Loneliness
threat".
Review
25
(1):
Harvard
pp.107-110.
MLA
Anna
et
al.
threat."
vol.
25,
no.
1,
2023,
pp.
Vancouver
Language: Английский
Subclinical Hypothyroidism, BDNF, and Telomere Dynamics in T1DM Pregnancy
Josip Đelmiš,
No information about this author
Vesna Elveđi-Gašparović,
No information about this author
Mislav Herman
No information about this author
et al.
Published: April 29, 2024
This
study
investigates
the
effects
of
subclinical
hypothyroidism
and
BDNF
on
telomere
length
in
T1DM
mothers
their
neonates.
Methods:
In
this
prospective
cohort
study,
70
pregnant
women
with
were
enrolled.
Subclinical
during
first
trimester
was
characterized
by
elevated
thyroid-stimulating
hormone
(TSH)
levels
ranging
from
2.5
to
5.0mIU/L
alongside
normal
free
thyroxine
(FT4)
concentrations.
Participants
stratified
into
two
groups
based
TSH
levels:
a
maternal
hypothyroid
group
(SHG,
n=35)
euthyroid
(ETG,
n=35).
Leukocyte
(LTL)
measurements
conducted
using
whole
blood
samples
umbilical
veins.
Results:
The
LTL
mean
1.7
(SD=1.1),
which
significantly
shorter
than
neonatal
telomeres,
2.3
SD
(1.2).
A
significant
correlation
observed
between
(r=0.750,
p<0.001).
positive
association
found
circulation
[β=0.421
(95%
CI
0.536;
1.873;
p=0.001)].
Neonatal
negatively
associated
gestational
weight
gain
[β=-0.266
CI-0.138;
-0.009)],
[β=-0.237;
-0.493;
-
0.010)].
Notably,
neonates
SHG
exhibited
LTL,
2.1
(1.0),
compared
those
ETG,
who
had
2.7
(1.4).
[β=0.523
0.790;
1.950;
P<0.001)].
Maternal
[β=-0.259
-0.122;
-0.010)],
[β=-0.231;
-0.422;
0.015)].
Conclusions:
Genetic
factors
affect
LTL.
reduces
link
reveals
complex
endocrine-neurotrophic
interaction
dynamics.
Language: Английский
Mortality was predicted by depression and functional dependence in a cohort of elderly adults of Italian descent from southern Brazil
Scientific Reports,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: April 3, 2023
Abstract
The
older
population
has
an
increasing
burden
of
non-communicable
disease,
which
can
potentially
be
associated
with
physical
and
mental
disabilities
shorten
life
spam.
To
investigate
whether
depression,
loss
functionality
for
activities
daily
living,
lower
social
support
are
all-cause
mortality
in
the
Italian
descent.
This
population-based
cohort
study
was
conducted
Veranópolis,
a
country
city
from
southern
Brazil,
among
individuals
aged
60
years
or
older.
Interviews
were
performed
systematic
random
sampling
regarding
demographic,
socioeconomic,
psychosocial
variables,
addition
to
depression
(Geriatric
Depression
Scale),
living
(Barthel
Index),
(Medical
Outcomes
Study
scale).
In
follow-up,
participants
reinterviewed
or,
case
death,
next
kin,
hospital
records
revised.
Hierarchical
analysis
used
determine
characteristics
independently
mortality,
using
Poisson
regression
robust
variance,
expressed
as
relative
risk
95%
confidence
intervals
(RR;
95%CI).
A
total
997
enrolled
882
completed
study,
after
7.24
±
2.41
years;
581
remaining
alive.
mean
age
73.12
8.03
years,
4%
nonagenarians
centennials,
62%
women.
Symptoms
(RR:
1.04;
1.01–1.06)
functional
dependence
ADL
1.00;
0.99–1.00)
even
controlling
confounding
factors.
Lower
not
0.99–1.01).
independent
predictors
Language: Английский
Consequences of the isolation in vulnerable populations: Brain and mental health in the older population
Elsevier eBooks,
Journal Year:
2024,
Volume and Issue:
unknown, P. 69 - 89
Published: Jan. 1, 2024
Language: Английский
Impact of Family Function on the Quality of Life and Health Perception of Non-Institutionalized Dementia Patients
Journal of Alzheimer s Disease,
Journal Year:
2023,
Volume and Issue:
94(3), P. 963 - 975
Published: June 20, 2023
Dementia
is
one
of
the
pathologies
that
has
increased
most
among
older
population
(mainly
Alzheimer's
disease),
and
it
a
direct
impact
on
quality
life
(QoL),
cognitive
performance,
health
these
patients.
Family
functionality
can
play
role
in
this
QoL
if
patients
are
not
institutionalized.To
analyze
family
function
perception
non-institutionalized
dementia
patients,
as
well
related
variables
such
anxiety,
depression,
optimism,
or
pessimism.Cross-sectional
study
with
sample
54
diagnosed
some
type
dementia,
non-institutionalized,
outpatient
care,
from
different
centers
province
Valencia
(Spain).
The
EQ-5D,
MMSE,
Apgar
general
health,
Goldberg
anxiety
depression
questionnaires
were
utilized.The
correlation
General
Health
Questionnaire-new
onset
problems
variable
(GHQ)
Chronicity
Questionnaire-chronic
(CGHQ)
Quality
Life
questionnaire
was
statistically
significant
negative
(GHQ
r
=
-0.310;
p
0.034.
CGHQ
-0.363;
0.012);
between
Anxiety-Depression
(r
-0.341;
0.020).
Orientation
Test-Pessimism
(LOT)
-0.270;
0.061).
Finally,
severe
dysfunction
self-perception
(p
0.036
B
-16.589)
determined
by
Visual
Analogue
Scale
(VAS).Family
directly
influences
pessimism.
This
could
explain
why
to
their
health.
Language: Английский
The effects of living arrangements on dietary diversity and depression among Chinese older adults
Xiaobing Xian,
No information about this author
Yu Rong,
No information about this author
Linhan Qu
No information about this author
et al.
Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Aug. 10, 2023
Abstract
Background
There
is
growing
evidence
that
addressing
the
health
problems
associated
with
population
aging
imminent.
We
aimed
to
explore
effects
of
living
arrangements
on
dietary
diversity
and
mental
from
an
older
Chinese
examine
mediating
role
provide
a
theoretical
basis
for
how
better
promote
healthy
aging.
Methods
Using
data
seventh
Longitudinal
Healthy
Longevity
Survey
(CLHLS)
including
relevant
basic
demographic
characteristics
variables
as
control
variables,
this
study
used
logistic
regression
investigate
relationship
between
adults
diversity,
depression
anxiety,
PROCESS
procedure
test
effects.
Results
Older
their
families
those
in
nursing
homes
had
higher
scores
compared
alone.
were
more
likely
acquire
than
alone,
family
members
at
lower
risk
depression.
was
no
significant
effect
arrangement
anxiety.
The
significant.
Conclusion
Living
directly
affect
people's
depression,
mediates
Our
findings
can
contribute
current
theory
knowledge
insights
into
social
policy,
elderly
services,
work
interventions
China.
Language: Английский