Toxic epidermal necrolysis – clinicopathological aspects and therapeutic management

Romanian Journal of Morphology and Embryology, Journal Year: 2025, Volume and Issue: 65(4), P. 765 - 773

Published: Feb. 13, 2025

Toxic epidermal necrolysis (TEN) is a serious dermatological condition often triggered by different drugs or medications or, less commonly, infections, leading to extensive detachment and multisystemic complications, resembling the severity systemic impact of burn injuries. This case report portrays 26-year-old female patient with history psychiatric treatment recreational drug use, presenting typical prodromal symptoms characteristic manifestations on integument mucosae. Clinical management involved an interdisciplinary team in center, administering immunoglobulins, steroids, supportive therapies prevent complications including infection support skin re-epithelization. Histopathological findings confirmed diagnosis. Despite lesions, prompt facilitated positive outcome. The emphasizes necessity referral specialized centers complex, multidisciplinary required for TEN patients optimize survival minimize long-term sequelae.

Language: Английский

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Utilization of Suprathel® in delayed surgical management of toxic epidermal necrolysis (TEN): A case report

Burns Open, Journal Year: 2025, Volume and Issue: unknown, P. 100399 - 100399

Published: Feb. 1, 2025

Language: Английский

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Etanercept Combined with Glucocorticoid and Gamma Globulin for Treating Children with Toxic Epidermal Necrolysis: A Case Report

Clinical Cosmetic and Investigational Dermatology, Journal Year: 2024, Volume and Issue: Volume 17, P. 167 - 171

Published: Jan. 1, 2024

Abstract: Toxic epidermal necrolysis (TEN) is a type of drug eruption in dermatology emergencies that rare clinical practice but has high mortality rate. The main causes are and viral infections. Unfortunately, no expert consensus on treating this disease exists, standard therapy absent. Up to now, glucocorticoids combined with gamma globulin commonly used practice, their efficacy highly controversial. This study reports 7-year-old girl TEN who did not respond traditional therapy, such as methylprednisolone globulin, was finally cured an additional low-dose etanercept. results showed etanercept paediatric safe, reliable worth recommending. Keywords: child toxic necrolysis, etanercept, glucocorticoids,

Language: Английский

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Oral cyclosporine treatment for four pediatric patients with toxic epidermal necrolysis that showed no response to high-dose corticosteroids in combination with intravenous immunoglobulin: A Case series

Current Therapeutic Research, Journal Year: 2024, Volume and Issue: 102, P. 100767 - 100767

Published: Dec. 3, 2024

Immunosuppressive agents like cyclosporine have proven effective in some pediatric cases, although there are limited case reports considering potential risks such as secondary infections. This study investigated the safety and efficacy of Cyclosporine A children who did not respond to high-dose corticosteroids combined with intravenous immunoglobulin (IVIG). We reported four patients diagnosed toxic epidermal necrolysis (TEN) received treatment at our institution. All were previously healthy a median age 7 years, comprising three boys one girl (Table 1). Epidermal exfoliation vesicular lesions ranged from 32.5% 54.5% body surface area (BSA). Despite administration (IVIG), new cutaneous herpes continually emerged. prompted transition (3-5 mg/kg/d) administered 1-2 oral doses. Lesions stopped progressing, bullous started epithelialization after 13-27 days hospitalization. Cases 1 2 faced bacterial fungal infections, respectively, their temperatures stabilized antibiotics. 3 4 experienced fever again when dosage was tapered off, no discernible evidence infection. The patients' normalized upon continuation therapy. Among patients, presented asymptomatic elevated serum amylase, which met diagnostic criteria for acute pancreatitis. Two showed mildly raised aminotransferases, experiencing mild coronary artery dilation, two contracted onychomadesis, developed corneal ulceration/keratitis atretoblepharia, eventually resolved vigorous ophthalmologic treatment. None had any permanent sequelae being discharged hospital six months. is generally safe fail combination IVIG.

Language: Английский

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Suprathel® and water-filtered infrared-A radiation (wIRA) as a new treatment strategy for toxic epidermal necrolysis (TEN): A prospective study

Burns, Journal Year: 2024, Volume and Issue: 50(9), P. 107283 - 107283

Published: Oct. 19, 2024

Language: Английский

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Necrólisis epidérmica toxica en un paciente de 13 años

Ciencia Latina Revista Científica Multidisciplinar, Journal Year: 2023, Volume and Issue: 7(3), P. 8290 - 8297

Published: July 13, 2023

La Necrolisis Epidermica Tóxica (NET) es una entidad cutánea debida a hipersensibilidad retardada frecuentemente ante medicamentos, y posee incidencia de aproximadamente 1 caso por cada millón personas. Presentamos el un paciente 13 años edad con antecedente síndrome convulsivo tratado ácido valproico, cual 15 días después del cambio medicamento fenitoína comienza presentar sintomatología propia la enfermedad. Es ingresado tratamiento se encuentra cargo pediatría, inmunología, oftalmología cirugía plástica.

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Tata Laksana Terintegrasi Sindrom Stevens-Johnson (SJS) dan Nekrolisis Epidermal Toksik (NET)

Cermin Dunia Kedokteran, Journal Year: 2023, Volume and Issue: 50(10), P. 549 - 554

Published: Oct. 2, 2023

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute life-threatening mucocutaneous reactions characterized by extensive necrosis detachment. The incidence of SJS in Japan is 2.3 cases/100,000 people/per year. mortality rate SJS-TEN Saudi Arabia 1 per 10 cases (10%). can be caused drugs, idiopathic, infection, post-bone marrow transplant, immunization, radiotherapy, genetics. pathogenesis suspected as a result cytotoxic reaction to keratinocyte cells which causes massive apoptosis. Clinical manifestation begins with prodromal symptoms followed erythematous macular lesions atypical target that may confluence, then develop into bullous, oozing erosions mucosal involvement. Vital sign observation important predict prognosis. A diagnostic procedure necessary if another diagnosis being considered. Management includes cessation early treatment such fluid resuscitation, nutrition, evaluation eyes skin lesions. Multiorgan involvement occur so multidisciplinary management needed for optimal therapy. Corticosteroids cyclosporin provide beneficial effects on SJS-TEN. SCORTEN used evaluate

Language: Английский

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